1,007
Participants
Start Date
October 9, 2017
Primary Completion Date
February 16, 2024
Study Completion Date
April 23, 2025
Pembrolizumab
IV infusion
Placebo
IV infusion
Cisplatin
IV infusion
Capecitabine
Oral tablets
5-fluorouracil
IV infusion
Docetaxel
IV infusion
Oxaliplatin
IV infusion
Leucovorin
IV infusion
Mackay Memorial Hospital ( Site 0065), Taipei
Taipei Medical University Shuang Ho Hospital ( Site 0068), New Taipei City
Chang Gung Medical Foundation. Linkou ( Site 0064), Taoyuan District
National Cheng Kung University Hospital ( Site 0067), Tainan City
Institut Jules Bordet ( Site 0480), Brussels
Hopital Erasme ULB ( Site 0484), Brussels
Riga East Clinical University Hospital ( Site 0550), Riga
St. Luke s Medical Center ( Site 0622), Quezon City
UCL Saint Luc ( Site 0479), Brussels
UZ Leuven ( Site 0483), Leuven
CHU de Liege ( Site 0482), Liège
CHU UCL Namur Site de Godinne ( Site 0485), Yvoir
Grand Hopital de Charleroi ( Site 0478), Charleroi
AZ Groeninge ( Site 0481), Kortrijk
UZ Gent ( Site 0486), Ghent
National Taiwan University Hospital ( Site 0063), Taipei
Laura and Isaac Perlmutter Cancer Center at NYU Langone Health ( Site 0019), New York
Memorial Sloan Kettering ( Site 0024), New York
Weill Cornell Medical Center ( Site 0023), New York
Koo Foundation Sun Yat-Sen Cancer Center ( Site 0066), Taipei
Institut Paoli Calmettes ( Site 0472), Marseille
SA Pohja-Eesti Regionaalhaigla ( Site 0526), Tallinn
Seoul National University Bundang Hospital ( Site 0085), Seongnam-si
Roswell Park Cancer Institute ( Site 0001), Buffalo
University of Rochester ( Site 0011), Rochester
Fox Chase Cancer Center ( Site 0006), Philadelphia
Temple University Hospital ( Site 0026), Philadelphia
Georgetown University ( Site 0015), Washington D.C.
Istituto Clinico Humanitas Research Hospital ( Site 0432), Rozzano
IRCCS Policlinico San Donato ( Site 0433), San Donato Milanese
Fondazione IRCCS Istituto Nazionale dei Tumori di Milano ( Site 0430), Milan
Haematologisch-Onkologische Praxis Eppendorf Facharztzentrum Eppendorf - Hope ( Site 0454), Hamburg
Gachon University Gil Medical Center ( Site 0087), Incheon
Virginia Cancer Specialists, PC ( Site 0010), Fairfax
CHU Brest - Institut de Cancerologie et d Hematologie ( Site 0474), Brest
Medizinische Hochschule Hannover ( Site 0449), Hanover
CHU Toulouse - Hopital Rangueil ( Site 0470), Toulouse
Rambam Health Care Campus ( Site 0381), Haifa
A.O.U. Santa Maria della Misericordia di Udine ( Site 0434), Udine
Institut du Cancer de Montpellier ( Site 0473), Montpellier
Centre Eugene Marquis ( Site 0466), Rennes
IRCCS Istituto Oncologico Veneto ( Site 0431), Padova
Azienda Ospedaliero Universitaria di Modena Policlinico ( Site 0429), Modena
Kyungpook National University Chilgok Hospital ( Site 0089), Daegu
Institut de Cancerologie de l Ouest Centre Rene Gauducheau ( Site 0469), Saint-Herblain
Kliniken Essen Mitte Gmbh Evang. Huyssens Stiftung ( Site 0445), Essen
City Clinical Hosp.4 of DCC ( Site 0325), Dnipro
MI Kryvyi Rih Oncology Dispensary of Dnipropetrovsk Regional Council ( Site 0589), Kryviy Rih
LSMUL Kauno Klinikos ( Site 0570), Kaunas
Hospital Kuala Lumpur ( Site 0146), Kuala Lumpur
CHU Reims - Hopital Robert Debre ( Site 0465), Reims
Medizinische klinilk und Poliklinik Johannes Gutenberg Univ ( Site 0455), Mainz
Chonnam National University Hwasun Hospital ( Site 0083), Hwasun Gun
CHRU Lille - Hopital Claude Huriez ( Site 0461), Lille
University Malaya Medical Centre ( Site 0143), Kuala Lumpur
Northwestern University - Robert H. Lurie Comprehensive Cancer Center ( Site 0018), Chicago
The University of Chicago Medical Center ( Site 0004), Chicago
Communal non profit enterprise Regional Clinical Oncology Center ( Site 0591), Kharkiv
Hopital Prive Jean Mermoz ( Site 0462), Lyon
Klinikum Esslingen GmbH ( Site 0453), Esslingen am Neckar
CHU Hopital Saint Antoine ( Site 0471), Paris
Institut Mutualiste Montsouris ( Site 0463), Paris
Ivano-Frankivsk Regional Oncology Clinical Dispensary ( Site 0321), Ivano-Frankivsk
Universitaetsklinikum Freiburg ( Site 0450), Freiburg im Breisgau
Seconda Universita Napoli ( Site 0436), Napoli
Klinikum der Universitaet in Muenchen ( Site 0446), Munich
University of Utah, Huntsman Cancer Institute ( Site 0012), Salt Lake City
CHU Poitiers - Pole Regional de Cancerologie ( Site 0467), Poitiers
City of Hope ( Site 0005), Duarte
Beijing Cancer Hospital ( Site 0221), Beijing
National Medical and Surgical Center n.a. N.I.Pirogov ( Site 0338), Moscow
Blokhin National Medical Oncology ( Site 0494), Moscow
National University Hospital ( Site 0095), Singapore
National Cancer Centre Singapore ( Site 0097), Singapore
Leningrad Regional Oncology Center ( Site 0335), Saint Petersburg
SBHI Leningrad Regional Clinical Hospital ( Site 0496), Saint Petersburg
Scientific Research Oncology Institute n.a. N.N.Petrov ( Site 0344), Saint Petersburg
City clinical oncological dispensary ( Site 0336), Saint Petersburg
Kaluga Regional Clinical Oncology Center ( Site 0345), Kaluga
Oncocare Cancer Centre ( Site 0096), Singapore
Zhejiang Cancer Hospital ( Site 0231), Hangzhou
Sir Run Run Shaw Hospital ( Site 0233), Hangzhou
Tomsk Scientific Research Institute of Oncology ( Site 0337), Tomsk
Hospital Regional Rancagua Libertador Bernardo O Higgins ( Site 0299), Rancagua
Meir medical center ( Site 0386), Kfar Saba
Instituto Clinico del Sur. ICOS ( Site 0290), Temuco
Rabin-Medical Center ( Site 0384), Petah Tikva
Sheba Medical center ( Site 0387), Ramat Gan
Sourasky Medical Center. ( Site 0382), Tel Aviv
Fundacion Arturo Lopez Perez FALP ( Site 0286), Santiago
Pontificia Universidad Catolica de Chile ( Site 0285), Santiago
Hospital Clinico Universidad de Chile ( Site 0287), Santiago
Soroka University M.C ( Site 0385), Beersheba
Hadassah Medical Center. Ein Kerem ( Site 0383), Jerusalem
Yale Cancer Center ( Site 0016), New Haven
Instituto do Cancer do Ceara ( Site 0311), Fortaleza
Uniao Brasileira de Educacao e Assistencia Hospital Sao Lucas da Pucrs ( Site 0308), Porto Alegre
CEPON - Centro de Pesquisas Oncologicas ( Site 0302), Florianópolis
Fundacao Pio XII - Hospital de Cancer de Barretos ( Site 0301), Barretos
Hospital de Base de Sao Jose de Rio Preto ( Site 0304), Sao Jose Rio Preto
Instituto Nacional Do Cancer Jose Alencar Gomes Da Silva ( Site 0307), Rio de Janeiro
Instituto do Cancer do Estado de Sao Paulo - ICESP ( Site 0305), São Paulo
Hospital Israelita Albert Einstein ( Site 0309), São Paulo
Cross Cancer Institute ( Site 0033), Edmonton
Moncton Hospital - Horizon Health Network ( Site 0038), Moncton
Sunnybrook Research Institute ( Site 0032), Toronto
CISSS de la Monteregie-Centre ( Site 0039), Greenfield Park
CIUSSS de l Est de L Ile de Montreal - Hopital Maisonneuve-Rosemont ( Site 0040), Montreal
Jewish General Hospital ( Site 0034), Montreal
CHU de Quebec - Hotel-Dieu de Quebec ( Site 0042), Québec
CIUSSS de l Estrie - CHUS - Centre Hosp. Univ. Sherbrooke ( Site 0035), Sherbrooke
Universitaetsklinikum Carl Gustav Carus der TU Dresden ( Site 0448), Dresden
Integra Cancer Institute ( Site 0262), Guatemala City
Grupo Medico Angeles ( Site 0261), Guatemala City
Centro Medico Integral De Cancerología (CEMIC) ( Site 0260), Quetzaltenango
Aichi Cancer Center Hospital ( Site 0165), Nagoya
National Cancer Center Hospital East ( Site 0178), Kashiwa
National Hospital Organization Shikoku Cancer Center ( Site 0186), Matsuyama
Hokkaido University Hospital ( Site 0160), Sapporo
Hyogo Cancer Center ( Site 0182), Akashi
Kobe University Hospital ( Site 0188), Kobe
Kobe City Medical Center General Hospital ( Site 0181), Kobe
Ibaraki Prefectural Central Hospital ( Site 0177), Kasama
Iwate Medical University Hospital ( Site 0184), Shiwa-gun
St. Marianna University School of Medicine Hospital ( Site 0187), Kawasaki
Kanagawa Cancer Center ( Site 0167), Yokohama
Kansai Medical University Hospital ( Site 0190), Hirakata
Osaka University Hospital ( Site 0162), Suita
Osaka Medical College Hospital ( Site 0168), Takatsuki
Saitama Cancer Center ( Site 0170), Kitaadachi-gun
Shizuoka Cancer Center Hospital and Research Institute ( Site 0176), Sunto-gun
Chiba Cancer Center ( Site 0180), Chiba
National Hospital Organization Kyushu Cancer Center ( Site 0172), Fukuoka
Kyushu University Hospital ( Site 0173), Fukuoka
Gifu University Hospital ( Site 0166), Gifu
Hiroshima City Hiroshima Citizens Hospital ( Site 0171), Hiroshima
Kochi Health Sciences Center ( Site 0189), Kochi
Kumamoto University Hospital ( Site 0164), Kumamoto
Niigata Cancer Center Hospital ( Site 0169), Niigata
Osaka International Cancer Institute ( Site 0161), Osaka
Osaka General Medical Center ( Site 0159), Osaka
National Cancer Center Hospital ( Site 0179), Tokyo
Tokyo Metropolitan Komagome Hospital ( Site 0183), Tokyo
The Cancer Institute Hospital of JFCR ( Site 0185), Tokyo
Toyama Prefectural Central Hospital ( Site 0163), Toyama
Nacionalinis Vezio Institutas ( Site 0569), Vilnius
Vilniaus Universiteto Ligonine Santaros Klinikos ( Site 0568), Vilnius
Szpital Uniwersytecki w Krakowie ( Site 0352), Krakow
Wojewodzki Szpital Specjalistyczny we Wroclawiu ( Site 0358), Wroclaw
Samodzielny Publiczny Szpital Kliniczny Nr 1 w Lublinie ( Site 0351), Lublin
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie ( Site 0349), Warsaw
Mazowiecki Szpital Onkologiczny ( Site 0363), Wieliszew
Szpital Specjalistyczny w Koscierzynie Sp. z o.o. ( Site 0353), Kościerzyna
Beskidzkie Centrum Onkologii im. Jana Pawla II ( Site 0354), Bielsko-Biala
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie ( Site 0361), Gliwice
SPZOZ WSS nr 3 w Rybniku ( Site 0357), Rybnik
Korea University Anam Hospital ( Site 0084), Seoul
Seoul National University Hospital -SNUH- ( Site 0080), Seoul
Severance Hospital Yonsei University Health System ( Site 0081), Seoul
Asan Medical Center ( Site 0082), Seoul
Gangnam Severance Hospital ( Site 0088), Seoul
SMG-SNU BORAMAE Medical Center ( Site 0086), Seoul
National Cancer Institute of the MoH of Ukraine ( Site 0319), Kyiv
Kyiv City Clinical Oncology Center ( Site 0590), Kyiv
University Hospitals Bristol NHS Foundation Trust ( Site 0407), Bristol
Ninewells Hospital and Medical School ( Site 0406), Dundee
Royal Free London NHS Foundation Trust ( Site 0403), London
The Royal Marsden Foundation Trust ( Site 0405), London
Imperial College Healthcare NHS Trust ( Site 0402), London
Royal Marsden NHS Foundation Trust ( Site 0400), Sutton
The Christie NHS Foundation Trust ( Site 0397), Manchester
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INDUSTRY