NCT03221400 - PEN-866 in Patients With Advanced Solid Malignancies | Biotech Hunter

Enrollment

340

Participants

Timeline

Start Date

August 29, 2017

Primary Completion Date

January 31, 2023

Study Completion Date

June 30, 2023

Conditions

CarcinomaEndometrial AdenocarcinomaNeoplasmsSquamous Cell Carcinoma of the AnusAdenocarcinoma of the PancreasAdvanced CancerSolid TumorSolid CarcinomaSquamous Cell Carcinoma of the CervixSquamous Cell CarcinomaSquamous Cell Carcinoma of the VulvaSquamous Cell Carcinoma of the PenisGastric CancerGastric AdenocarcinomaGastroesophageal Junction AdenocarcinomaSmall-cell Lung CancerSmall Cell Lung CarcinomaPancreatic Ductal AdenocarcinomaPancreatic Adenocarcinoma

Interventions

DRUG

PEN-866 Sodium

PEN-866 Sodium is a miniaturized conjugate that comprises an HSP90 targeting ligand linked to SN-38, the active metabolite of irinotecan. PEN-866 is available as a sterile lyophilized powder for solution for infusion.

DRUG

fluorouracil

Fluorouracil 2400 mg/m2 IV

DRUG

Folinic acid

Folinic acid 400 mg/m2 IV

DRUG

Niraparib

Trial Locations (16)

19107

RECRUITING

Sidney Kimmel Cancer Center at Thomas Jefferson University Hospital, Philadelphia

20892

RECRUITING

National Institutes of Health / National Cancer Institute, Bethesda

22031

RECRUITING

Virginia Cancer Specialists, Fairfax

29605

RECRUITING

Prisma Health - Upstate, Greenville

33401

RECRUITING

Florida Cancer Specialists - East, West Palm Beach

33705

RECRUITING

Florida Cancer Specialists - North, St. Petersburg

33901

RECRUITING

Florida Cancer Specialists - South, Fort Myers

37203

RECRUITING

Tennessee Oncology, Nashville

38138

RECRUITING

The West Clinic, Germantown

48202

RECRUITING

Henry Ford, Detroit

53226

RECRUITING

Medical College of Wisconsin, Milwaukee

68130

RECRUITING

Nebraska Cancer Specialists, Omaha

72762

RECRUITING

Highlands Oncology Group, Springdale

73104

RECRUITING

Stephenson Cancer Center, University of Oklahoma, Oklahoma City

80218

RECRUITING

Sarah Cannon Reasearch Institute at HealthONE, Denver

89169

RECRUITING

Comprehensive Cancer Centers of Nevada, Las Vegas