SBRT + PD-1/PDL-1 Inhibiting Therapy for Advanced Solid Tumors After Dz Control on PD-1/PDL-1 Tx

PHASE2CompletedINTERVENTIONAL
Enrollment

5

Participants

Timeline

Start Date

October 10, 2017

Primary Completion Date

January 27, 2020

Study Completion Date

September 22, 2021

Conditions
Solid Tumor
Interventions
RADIATION

Stereotactic radiotherapy

Treatment will be planned to deliver a total of 18 to 60 Gy to the planning target volume (PTV) in 3 to 5 fractions over 1 to 2 weeks.

OTHER

Biological: humanized anti-PD-1 monoclonal antibody

Standard of Care - patient will continue to be given the same PD-1 inhibitor they were receiving prior to study registration

OTHER

Biological: humanized anti-PD-L1 monoclonal antibody

Standard of Care - patient will continue to be given the same PD-L1 inhibitor they were receiving prior to study registration

Trial Locations (1)

23298

Virginia Commonwealth University/Massey Cancer Center, Richmond

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

Virginia Commonwealth University

OTHER

NCT03220854 - SBRT + PD-1/PDL-1 Inhibiting Therapy for Advanced Solid Tumors After Dz Control on PD-1/PDL-1 Tx | Biotech Hunter | Biotech Hunter