MGMT-NET: O6-methylguanine-DNA Methyltransferase (MGMT) Status in Neuroendocrine Tumors: Predictive Factor of Response to Alkylating Agents

NACompletedINTERVENTIONAL
Enrollment

116

Participants

Timeline

Start Date

October 16, 2018

Primary Completion Date

January 31, 2022

Study Completion Date

April 25, 2022

Conditions
Neuroendocrine Tumors
Interventions
DRUG

Oxaliplatin-based chemotherapy

"The oxaliplatin-based group will receive gemox (gemcitabine-oxaliplatin, 1x/2 week); alternatively folfox (5 fluorouracil-leucovorin-oxaliplatin, 1x/2 week) or capox (capecitabine-oxaliplatin, 1x/3 week)."

DRUG

Alkylating-based chemotherapy

"The alkylating-based group will receive CapTem regimen (capecitabine and temozolomide, /4 week), alternatively LV5FU2 (folinic acid-5 fluorouracil)-dacarbazine (1x/2 week) or LV5FU2 (folinic acid-5-fluorouracil)-streptozotocine (1x/2 week)."

Trial Locations (19)

13009

Institut Paoli Calmettes, Marseille

21000

Hôpital François Mitterrand - CHU Dijon Bourgogne, Dijon

31059

Hôpital Rangueil - CHU Toulouse, Toulouse

37044

Hôpital Trousseau - CHU Tours, Tours

42270

Hôpital Nord - CHU Saint Etienne, Saint-Priest-en-Jarez

Institut de Cancérologie de la Loire, Saint-Priest-en-Jarez

49933

CHU d'Angers, Angers

51092

Hôpital Robert Debré - CHU Reims, Reims

59020

Centre Oscar Lambret, Lille

59037

Hôpital Claude Hurriet - CHRU Lille, Lille

63003

Hôpital Estaing, CHU de Clermont-Ferrand, Clermont-Ferrand

69003

Hôpital Edouard Herriot - Hospices Civils de Lyon, Lyon

69008

Hôpital Privé Jean Mermoz, Lyon

74374

CH Annecy Genevois, Pringy

75010

Hôpital Saint Louis - APHP, Paris

75014

Hôpital Cochin - APHP, Paris

80054

Hôpital Sud - CHU Amiens, Amiens

92118

Hôpital Beaujon - APHP, Clichy

94805

Institut Gustave Roussy, Villejuif

All Listed Sponsors
lead

Hospices Civils de Lyon

OTHER

NCT03217097 - MGMT-NET: O6-methylguanine-DNA Methyltransferase (MGMT) Status in Neuroendocrine Tumors: Predictive Factor of Response to Alkylating Agents | Biotech Hunter | Biotech Hunter