HIF-2 Alpha Inhibitor PT2385 in Treating Patients With Recurrent Glioblastoma

PHASE2CompletedINTERVENTIONAL
Enrollment

24

Participants

Timeline

Start Date

September 14, 2017

Primary Completion Date

August 31, 2019

Study Completion Date

June 5, 2020

Conditions
Recurrent Glioblastoma
Interventions
DRUG

HIF-2alpha Inhibitor PT2385

Given PO

OTHER

Pharmacological Study

Correlative studies

OTHER

Laboratory Biomarker Analysis

Correlative studies

OTHER

Pharmacogenomic Study

Correlative studies

Trial Locations (10)

10021

Memorial Sloan-Kettering Cancer Center, New York

15232

Hillman Cancer Center at University of Pittsburgh Cancer Institute, Pittsburgh

19104

Abrams Cancer Center of the University of Pennsylvania, Philadelphia

21231

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore

27157

Wake Forest University Comprehensive Cancer Center, Winston-Salem

44195

Cleveland Clinic Taussig Cancer Center, Cleveland

48202

Henry Ford Hospital, Detroit

90095

Jonsson Comprehensive Cancer Center at UCLA, Los Angeles

35294-3410

UAB Comprehensive Cancer Center, Birmingham

02115

Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute, Boston

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

collaborator

Peloton Therapeutics, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)

INDUSTRY

lead

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

OTHER

NCT03216499 - HIF-2 Alpha Inhibitor PT2385 in Treating Patients With Recurrent Glioblastoma | Biotech Hunter | Biotech Hunter