Study of Renin-angiotensin System in Mechanically Ventilated Subjects

Local standard of care will include fluid resuscitation, use of vasopressor drugs and renal support.

Mechanical ventilation will be based on volume-assist control mode, with a target tidal volume of 6-8 milliliter per kg (mL/kg) and a target plateau pressure of 30 centimeter of water (cmH2O).