DHA-PQP vs Chloroquine and Primaquine for Radical Cure of Vivax Malaria in Brazil

PHASE3CompletedINTERVENTIONAL
Enrollment

419

Participants

Timeline

Start Date

July 5, 2018

Primary Completion Date

July 2, 2021

Study Completion Date

July 2, 2021

Conditions
Malaria, VivaxTherapeutics
Interventions
DRUG

CQ coadministered with PQ

113 subjects in a 3-day regimen treatment with the schizonticidal drug Chloroquine concomitantly to 14-day regimen treatment with Primaquine in a dose of 0.50 mg/kg/day.

DRUG

DHA-PQP coadministered with PQ

In this treatment group, 112 subjects took DHA-PQP for three days and Primaquine for 14 days in the following dose: 0.50 mg/kg/day.

DRUG

CQ and PQ starting on Day 42

98 subjects in a 3-day regimen treatment with Chloroquine with a 14-day regimen treatment with Primaquine in a dose of 0.50 mg/kg/day starting on Day 42 after first dose of the schizonticidal drug.

DRUG

DHA-PQP and PQ starting on Day 42

95 subjects in a 3-day regimen treatment with DHA-PQP with a 14-day regimen treatment with Primaquine in a dose of 0.50 mg/kg/day starting on Day 42 after first dose of the schizonticidal drug.

Trial Locations (1)

69040000

Fundação de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus

All Listed Sponsors
collaborator

Ministry of Health, Brazil

OTHER_GOV

collaborator

Oswaldo Cruz Foundation

OTHER

lead

Fundação de Medicina Tropical Dr. Heitor Vieira Dourado

OTHER

NCT03208907 - DHA-PQP vs Chloroquine and Primaquine for Radical Cure of Vivax Malaria in Brazil | Biotech Hunter | Biotech Hunter