Epidural Morphine for Postoperative Analgesia After Total Knee Arthroplasty

NACompletedINTERVENTIONAL
Enrollment

110

Participants

Timeline

Start Date

July 1, 2017

Primary Completion Date

April 30, 2018

Study Completion Date

May 30, 2018

Conditions
Adult PatientsTotal Knee ArthroplastyEpidural AnalgesiaFemoral Nerve BlockAnalgesic Adverse Reaction
Interventions
PROCEDURE

Epidural morphine

2 mg of morphine (0.4 mg/ml morphine in 5 ml normal saline) is administered through the epidural catheter at the end of surgery.

PROCEDURE

Epidural placebo

5 ml normal saline is administered through the epidural catheter at the end of surgery.

PROCEDURE

Single femoral nerve block

Single femoral nerve block is performed with 20 ml 0.5% ropivacaine under the guidance of ultrasonography and nerve stimulator after surgery.

DRUG

Intravenous morphine analgesia

Intravenous morphine analgesia is provided with a patient-controlled analgesia pump which is established with 100 ml of 0.5 mg/ml morphine, programmed to deliver a 2 ml bolus with a lockout interval of 8-10 min and a background infusion of 0.5 ml/h.

Trial Locations (1)

100034

Peking University First Hospital, Beijing

All Listed Sponsors
lead

Peking University First Hospital

OTHER

NCT03203967 - Epidural Morphine for Postoperative Analgesia After Total Knee Arthroplasty | Biotech Hunter | Biotech Hunter