A Study to Determine the Safety and Efficacy of TG-C in Subjects with Kellgren and Lawrence Grade 2 or 3 OA of the Knee

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

535

Participants

Timeline

Start Date

October 30, 2018

Primary Completion Date

June 4, 2024

Study Completion Date

July 10, 2026

Conditions
Degenerative Osteoarthritis
Interventions
BIOLOGICAL

TG-C

2 mL injection of non-transduced human chondrocytes and irradiated transduced human GP2-293 cells expressing TGF-B1.

BIOLOGICAL

Placebo Control

2 mL normal saline injection

Trial Locations (46)

10022

Corey Hunter, New York

10075

Jason Oh, New York

16635

Alan Kivitz, Duncansville

20006

Mehul Desai, Washington D.C.

21215

Ronald Delanois, Baltimore

22901

James Clark, Charlottesville

24541

Mark Hermann, Danville

27704

Brett Gilbert, Durham

28412

Jeremy Hoff, Wilmington

29206

Edward Tavel, Columbia

29601

Eric Loudermilk, Greenville

30265

Sandeep Vaid, Newnan

32117

David Billmeier, Daytona Beach

32789

Anand Patel, Winter Park

33135

Mercedes Ponce De Leon, Miami

33144

Aurelio Torres-Consuegra, Miami

Edgar Gonzalez, Miami

33351

Richard Linn, Sunrise

34652

Cathy Barnes, New Port Richey

34677

Howard Chipman, Oldsmar

35205

Jeffrey Davis, Birmingham

35235

Bradly Goodman, Birmingham

37203

Harvey Bowles, Nashville

60523

Hythem Shadid, Oak Brook

60607

Dennis Levinson, Chicago

60640

Manish Jain, Chicago

68516

Melvin Churchill, Lincoln

70072

Adil Fatakia, Marrero

74104

Yogesh Mittal, Tulsa

75115

Haresh Boghara, DeSoto

75240

Amr Morsy, Dallas

77099

Subodh Bhuchar, Houston

77401

Daneshvari Solanki, Bellaire

78258

Brian MacGillivray, San Antonio

79225

Aldo Maspons, El Paso

84020

Angela Krull, Draper

84405

John Hemmersmeier, South Ogden

85032

Saima Chohan, Phoenix

85712

Nebojsa Skrepnik, Tucson

90403

Timothy Davis, Santa Monica

90602

Tien-I Su, Whittier

91722

Dan La, Covina

91942

Scott Hacker, La Mesa

92108

Arthur Mabaquiao, San Diego

92307

Diraj Karnani, Apple Valley

94558

Eric Grigsby, Napa

Sponsors
All Listed Sponsors
lead

Kolon TissueGene, Inc.

INDUSTRY