416
Participants
Start Date
October 5, 2017
Primary Completion Date
February 14, 2020
Study Completion Date
November 19, 2024
Cyclophosphamide
Participants will receive 300 mg/m\^2 of cyclophosphamide as an oral or IV dose.
Bortezomib
Participants will receive 1.3 mg/m\^2 of bortezomib as an subcutaneous (SC) injection.
Dexamethasone, 40 mg
Participants of CyBorD alone arm will receive 40 mg dexamethasone orally or IV dose. Participants of CyBorD plus daratumumab arm will receive dexamethasone 20 mg orally or IV dose as premedication and 20 mg on the day after daratumumab dosing to make a total of 40 mg.
Daratumumab
Participants will receive 1800 mg of daratumumab subcutaneously.
Institut Jules Bordet, Anderlecht
Semmelweis Egyetem I.Belgyogyaszati Klinika, Budapest
Semmelweis Egyetem I.Belgyogyaszati Klinika, Budapest
Del Pesti Centrumkorhaz Orszagos Hematologiai es Infektologiai Intezet Szent Laszlo Telephely, Budapest
Westmead Hospital, Westmead
Dep. of Hematology, Rigshospitalet, Copenhagen
Universitair Ziekenhuis Leuven, Leuven
Box Hill Hospital, Box Hill
Princess Alexandra Hospital, Woolloongabba
Odense Universitets Hospital, Odense
Sir Charles Gairdner Hospital, Nedlands
Akdeniz University Medical Faculty, Antalya
Az Groeninge, Kortrijk
UZ Gent, Ghent
Columbia University Medical Center, New York
Weill Cornell Medical College, New York
A.O.U. Città della Salute e della Scienza, Torino
Alexandra General Hospital of Athens, Athens
Charite Campus Benjamin Franklin, Berlin
Institut Paoli Calmettes, Marseille
University of Rochester Medical Center, Rochester
University of Pennsylvania Medical Center, Philadelphia
CHU Dijon, Dijon
University of Maryland, Baltimore
HOPA-Hämatologisch-Onkologische Praxis Altona MVZ GmbH, Hamburg
University General Hospital of Rio, Pátrai
Amyloidosis Research and Treatment Center, Fondazione IRCCS Policlinico San Matteo, Pavia
Wake Forest University Health Sciences - Cardiovascular Medicine, Winston-Salem
Hosp. Univ. Ramon Y Cajal, Madrid
Hosp Univ Fund Jimenez Diaz, Madrid
Hosp. Univ. 12 de Octubre, Madrid
Levine Cancer Institute, Charlotte
Winship Cancer Institute Emory University, Atlanta
Clinica Univ. de Navarra, Pamplona
CHU Rangueil, Toulouse
Mayo Clinic, Jacksonville
Istanbul University Istanbul Medical Faculty, Istanbul
Carmel Hospital, Haifa
Dokuz Eylul Universitesi Tip Fakultesi, Izmir
Hosp Clinico Univ de Salamanca, Salamanca
CHU Bretonneau, Tours
Sarah Cannon Research Institute, Nashville
Vanderbilt University Medical Center, Nashville
Erciyes University Medical Faculty, Talas
Hosp. Univ. de Canarias, San Cristóbal de La Laguna
Istituto di Ematologia Seràgnoli azienda ospedaliera univeristaria Policlinico S.Orsola-Malpighi, Bologna
Heinrich-Heine-Universität Düsseldorf, Düsseldorf
The Ohio State University, Columbus
Chu Hotel Dieu, Nantes
Centro de Investigación Farmacéutica Especializada, Guadalajara
Cleveland Clinic, Cleveland
Universitatsklinikum Essen, Essen
Hosp. Univ. Dr. Peset, Valencia
Barbara Ann Karmanos Cancer Institute, Detroit
Pusan National University Hospital, Busan
Sheba Medical Center, Ramat Gan
CHU de Nancy_ Hopital Brabois, Vandœuvre-lès-Nancy
Ondokuz Mayis Universitesi Tip Fakultesiy, Atakum
Mayo Clinic Rochester, Rochester
Hopital Claude Huriez, Lille
Washington University School Of Medicine, St Louis
Hospital Universitario Dr Jose Eleuterio Gonzalez, Monterrey
Universitaetsklinikum Heidelberg Medizinische Klinik V, Heidelberg
Centre hospitalier Lyon-Sud, Pierre-Bénite
Policlinico di Bari, Bari
Assaf Ha'Rofeh Medical Center, Ẕerifin
Universitaetsklinikum Tuebingen der Eberhard-Karls-Universitaet, Abteilung fuer Innere Medizin II,, Tübingen
Hopital Saint Louis, Paris
University of Texas, MD Anderson Cancer Center, Houston
University of Colorado, Aurora
Colorado Blood Cancer Institute, Denver
Huntsman Cancer Institute, Salt Lake City
Mayo Clinic Arizona, Phoenix
CHU De Poitiers, Poitiers
CHU de Limoges - Fédération Hépatologie, Limoges
Casa di Cura La Maddalena, Palermo
City of Hope, Duarte
Hadassah Medical Center, Jerusalem
University of California San Francisco, San Francisco
Stanford University, Stanford
Universitätsklinikum Würzburg Med. Klinik U. Poliklinik Ii, Würzburg
Oregon Health And Science University, Portland
Peking University First Hospital, Beijing
Peking University People s Hospital, Beijing
Ruijin Hospital Shanghai Jiao Tong University, Shanghai
First affiliated Hospital of Zhejiang University, Hangzhou
The First Affiliated Hospital of Wenzhou Medical University, Wenzhou
Sourasky Medical Center, Tel Aviv
Tufts Medical Center, Boston
Boston University Medical Center, Boston
Dana Farber Cancer Institute, Boston
Seattle Cancer Care Alliance, Seattle
Hospital das Clinicas de Porto Alegre, Porto Alegre
Sociedade Pernambucana de Combate ao Cancer, Recife
Instituto de Educacao, Pesquisa e Gestao em Saude Instituto Americas (COI), Rio de Janeiro
Hospital Sao Rafael, Salvador
Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto Hospital de Base, São José do Rio Preto
Clinica Sao Germano, São Paulo
Instituto de Assistencia Medica ao Servidor Publico Estadual IAMSPE, São Paulo
Hospital Das Clinicas Da Faculdade De Medicina Da USP, São Paulo
Arthur J E Child Comprehensive Cancer Centre, Calgary
Alberta Health Services, Edmonton
Vancouver General Hospital, Vancouver
London Health Sciences Center, London
University Health Network UHN Princess Margaret Cancer Centre, Toronto
McGill University Health Centre, Montreal
Aarhus University Hospital, Aarhus N
Dipartimento Di Biotecnologie Cellulari Ed Ematologia-Università ''La Sapienza'',Policlinico Umberto I, Roma
Fukushima Medical University Hospital, Fukushima
Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital, Hiroshima
Teine Keijinkai Hospital, Hokkaido
Kanazawa University Hospital, Kanazawa
Kumamoto University Hospital, Kumamoto
Kyoto Kuramaguchi Medical Center, Kyoto
Shinshu University Hospital, Matsumoto
Matsuyama Red Cross Hospital, Matsuyama
Nagoya City University Hospital, Nagoya
National Hospital Organization Okayama Medical Center, Okayama
Japanese Red Cross Medical Center, Shibuya City
Tokushima University Hospital, Tokushima
UMCG, Groningen
Erasmus MC, Rotterdam
Haga ziekenhuis, The Hague
UMC Utrecht, Utrecht
Maxima Medisch Centrum, Veldhoven
Samodzielny Publiczny Zaklad Opieki Zdrowotnej Zespol Szpitali Miejskich, Chorzów
SKPP UM w Poznaniu, Poznan
Instytut Hematologii i Transfuzjologii, Warsaw
Seoul National University Hospital, Seoul
Severance Hospital Yonsei University Health System, Seoul
Samsung Medical Center, Seoul
The Catholic University of Korea Seoul St Marys Hospital, Seoul
Inst. Cat. D'Oncologia-Badalona, Badalona
Hosp Univ Vall D Hebron, Barcelona
Hosp Clinic de Barcelona, Barcelona
South Elvsborg Hospital, Borås
Skanes universitetssjukhus, Lund
Ankara Universitesi Tip Fakultesi Cebeci Hastanesi, Ankara
University Hospitals Birmingham NHS Trust,, Birmingham
University College Hospital, London
Janssen Research & Development, LLC
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