A Study of Atezolizumab Compared With a Single-Agent Chemotherapy in Treatment Naïve Participants With Locally Advanced or Recurrent or Metastatic Non-Small Cell Lung Cancer Who Are Deemed Unsuitable For Platinum-Doublet Chemotherapy

PHASE3CompletedINTERVENTIONAL
Enrollment

453

Participants

Timeline

Start Date

September 11, 2017

Primary Completion Date

April 30, 2022

Study Completion Date

October 25, 2023

Conditions
Non-Small Cell Lung Cancer
Interventions
DRUG

Atezolizumab (MPDL3280A), an engineered anti-PD-L1 antibody

Atezolizumab will be administered via IV infusion once every three weeks (QW3).

DRUG

Vinorelbine

Vinorelbine will be administered per relevant local guidelines and Summary of Product Characteristics (SmPC) management.

DRUG

Gemcitabine

Gemcitabine will be administered per relevant local guidelines and SmPC management.

Trial Locations (91)

7

Mater Misericordiae University Hospital - Institute for Cancer Research, Dublin

1090

UZ Brussel, Brussels

1210

Centre Hospitalier de Luxembourg, Luxembourg

3000

UZ Leuven Gasthuisberg, Leuven

3600

Spital STS AG - Spital Thun Medizin Onkologie; MEDIZINISCHE KLINIK, Thun

4000

Complex Oncology Center (COC)-Plovidiv, Plovdiv

5000

Odense Universitetshospital, Onkologisk Afdeling R, Odense C

5800

Umhat Dr Georgi Stranski; Clinic of Chemotherapy, Pleven

6000

Grand Hôpital de Charleroi Notre Dame, Charleroi

6500

Ospedale Regionale di Bellinzona Medizin Onkologie, Bellinzona

8401

Kantonsspital Winterthur; Medizinische Onkologie, Winterthur

13125

Evang. Lungenklinik Berlin Klinik für Pneumologie, Berlin

15706

Complejo Hospitalario Universitario de Santiago (CHUS) ; Servicio de Oncologia, Santiago de Compostela

20900

Azienda Ospedaliera San Gerardo di Monza, Monza MI

22927

LungenClinic Großhansdorf GmbH; Klinische Forschung, Großhansdorf

28006

Hospital Universitario de la Princesa; Servicio de Oncologia, Madrid

28040

Hospital Universitario Clínico San Carlos; Servicio de Oncologia, Madrid

29010

Hospital Clinico Universitario Virgen de la Victoria; Servicio de Oncologia, Málaga

30008

Hospital General Universitario J.M Morales Meseguer; Servicio de Oncologia, Murcia

31000

Centro Estatal de Cancerologia de Chihuahua; ONCOLOGY, Chihuahua City

34376

Fachklinik für Lungenerkrankungen, Immenhausen

35032

Klinikum der Philipps-Universität Marburg, Marburg

41009

Hospital Universitario Virgen Macarena; Servicio de Oncologia, Seville

46015

Hospital Arnau de Vilanova (Valencia) Servicio de Oncologia, Valencia

48100

Ospedale Provinciale Santa Maria Delle Croci; Oncologia Medica, Ravenna

48903

Hospital de Cruces; Servicio de Oncologia, Bilbao

72076

Universitätsklinikum Tübingen; Innere Medizin VIII, Medizinische Onkologie und Pneumologie, Tübingen

78209

Oncologico Potosino, San Luis Potosí City

82131

Asklepios Klinik Gauting; Onkologisches Studienzentrum, Gauting

93053

Universitätsklinikum Regensburg; Klinik und Poliklinik für Innere Medizin II, Pneumologie, Regensburg

100000

Bach Mai Hospital, Hanoi

100142

Beijing Cancer Hospital, Beijing

110017

Max Super Speciality Hospital, New Delhi

110076

Indraprastha Apollo Hospitals, New Delhi

110085

Rajiv Gandhi Cancer Inst.&Research Center; Medical Oncology, New Delhi

200000

Shanghai Chest Hospital, Shanghai

230001

Anhui Provincial Hospital, Hefei

230002

Oncomedica S.A., Montería

300060

Tianjin Cancer Hospital, Tianjin

300166

Oncocenter Timisoara, Timi?oara

310009

The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou

380060

HealthCare Global Cancer Centre; Medical Oncology, Ahmedabad

391760

Kailash Cancer Hospital and Research Center, Vadodara

400012

Tata Memorial Hospital; Dept of Medical Oncology, Mumbai

400015

Institutul Oncologic Prof. Dr. Ion Chiricuta Cluj Napoca; Oncologie Medicala, Cluj-Napoca

400016

P.D. Hinduja Nat. Hospital & Med. Research Centre, Mahim(West)

400053

Kokilaben Dhirubhai Ambani Hospital & Medical Research Institute; Department of Rheumatologz, Mumbai

407280

Centrul de Radioterapie AMETHYST, Floreşti

410006

Hu Nan Provincial Cancer Hospital, Changsha

411001

Grant Medical Foundation, Ruby Hall Clinic, Pune

411004

Deenanath Mangeshkar Hospital & Research Centre, Pune

422002

HCG Manavata Cancer Centre, Nashik

430023

Union Hospital of Tongji Medical College, Dept. of Cancer Center; Cancer Center, Wuhan

500034

Indo-American Cancer Hospital & Research Center, Hyderabad

600004

Oncólogos de Occidente, Pereira

700000

Cho Ray Hospital, Hochiminh City

700160

Tata Medical Center; Department of Medical Oncology, Kolkata

C1125ABD

Fundación CENIT para la Investigación en Neurociencias, Buenos Aires

B7602CBM

Hospital Privado de Comunidad, Mar del Plata

R8500ACE

Clinica Viedma S.A., Viedma

90040-373

Hospital Nossa Senhora da Conceicao, Porto Alegre

90610-000

Hospital Sao Lucas - PUCRS, Porto Alegre

01246-000

Instituto do Cancer do Estado de Sao Paulo - ICESP, São Paulo

V5Z 4E6

BCCA-Vancouver Cancer Centre, Vancouver

E1C 8X3

Regional health authority A vitalite health network, Moncton

K1Y 4E9

Ottawa Hospital Research Institute, Ottawa

M5G 1Z5

Princess Margaret Cancer Center, Toronto

H3T 1E2

Jewish General Hospital, Montreal

Unknown

Fundacion Cardioinfantil, Bogotá

University Hospital Limerick - Clinical Trials Department, Limerick

050022

Fundación Centro de Investigación Clínica CIC, Medellín

Kazakh Scientific Research Institution Of Oncology and Radiology, Almaty

779 00

Fakultni nemocnice Olomouc; Pneumologicka klinika, Olomouc

06120

Krankenhaus Martha-Maria Halle-Doelau gGmbH; Klinik fuer Innere Medizin II, Halle

00152

Azienda Ospedaliera San Camillo Forlanini; U.O.C. Pneumologia Ad Indirizzo Oncologico 1, Rome

050054

Almaty Oncology Center, Almaty

03100

Health Pharma Professional Research, Mexico City

05-400

Mazowieckie Centrum Leczenia Chorob Pluc I Gruzlicy; Oddzial Iii, Otwock

02-781

Narod.Inst.Onkol. im. M.Sklodowskiej - Curie-Panst.Inst.Bad; Klinika Nowot.Pluca i Klatki Piers, Warsaw

3000-075

CHUC - Unidade de Pneumologia Oncológica; Hospital de Dia de Oncologia Edificio Sao Jeronimo, Coimbra

4200-072

IPO do Porto; Servico de Oncologia Medica, Porto

949 88

Specializovana nemocnica sv. Svorada Zobor, n.o.; Oddelenie klinickej onkologie, Nitra

917 75

Fakultna nemocnica Trnava, Trnava

08908

Institut Catala d Oncologia Hospital Duran i Reynals, Barcelona

CH63 4JY

Clatterbridge Cancer Centre, Bebington

B9 5SS

Birmingham Heartlands Hospital, Birmingham

TR1 3LQ

Royal Cornwall Hospital; Dept of Clinical Oncology, Cornwall

G42 9LF

New Victoria Hospital, Glasgow

NW1 2PG

University College London Hospitals NHS Foundation Trust - University College Hospital, London

M2O 4BX

Christie Hospital Nhs Trust; Medical Oncology, Manchester

YO31 8HE

YORK DISTRICT HOSPITAL; Haematology/Oncology Department, York

All Listed Sponsors
lead

Hoffmann-La Roche

INDUSTRY

NCT03191786 - A Study of Atezolizumab Compared With a Single-Agent Chemotherapy in Treatment Naïve Participants With Locally Advanced or Recurrent or Metastatic Non-Small Cell Lung Cancer Who Are Deemed Unsuitable For Platinum-Doublet Chemotherapy | Biotech Hunter | Biotech Hunter