7
Participants
Start Date
November 13, 2017
Primary Completion Date
April 11, 2024
Study Completion Date
April 11, 2024
Adenosine stress test MRI
Participants will receive a contrasted adenosine stress CMR examination on a 1.5T Siemens Avanto scanner (Siemens Medical Solutions, Malvern, PA) dedicated to cardiovascular imaging. Adenosine stress was selected due to attenuated endothelium dependent and -independent vasodilation after doxorubicin receipt in humans to allow the investigators to understand the potential effect of perivascular fibrosis on perfusion reserve. Standardized CMR protocols will be performed to measure LV volumes (to assess wall motion abnormalities and identify any potential myocardial dysfunction), Native T1, ECV, and myocardial perfusion reserve in the short-axis plane
Virginia Commonwealth University, Richmond
Wake Forest Baptist Heath, Winston-Salem
Wake Forest University
OTHER
Virginia Commonwealth University
OTHER