Myocardial Perfusion and Fibrosis in Cancer Survivors

CompletedOBSERVATIONAL
Enrollment

7

Participants

Timeline

Start Date

November 13, 2017

Primary Completion Date

April 11, 2024

Study Completion Date

April 11, 2024

Conditions
Myocardial FibrosisMyocardial InjuryChemotherapeutic Toxicity
Interventions
DIAGNOSTIC_TEST

Adenosine stress test MRI

Participants will receive a contrasted adenosine stress CMR examination on a 1.5T Siemens Avanto scanner (Siemens Medical Solutions, Malvern, PA) dedicated to cardiovascular imaging. Adenosine stress was selected due to attenuated endothelium dependent and -independent vasodilation after doxorubicin receipt in humans to allow the investigators to understand the potential effect of perivascular fibrosis on perfusion reserve. Standardized CMR protocols will be performed to measure LV volumes (to assess wall motion abnormalities and identify any potential myocardial dysfunction), Native T1, ECV, and myocardial perfusion reserve in the short-axis plane

Trial Locations (2)

23284

Virginia Commonwealth University, Richmond

27157

Wake Forest Baptist Heath, Winston-Salem

All Listed Sponsors
collaborator

Wake Forest University

OTHER

lead

Virginia Commonwealth University

OTHER

NCT03191461 - Myocardial Perfusion and Fibrosis in Cancer Survivors | Biotech Hunter | Biotech Hunter