41
Participants
Start Date
September 6, 2017
Primary Completion Date
May 1, 2023
Study Completion Date
May 1, 2023
Oral appliance
"An oral appliance (dental mouthpiece) will be used to improve upper airway patency. Patients who do not have their own custom dental oral appliance (various brands, commonly Herbst/Somnomed) will be provided with a device (BluePro, BlueSom) for the duration of the study.~Patients will also be administered sham (room air) at 4 L/min via nasal cannula."
Oxygen
Supplemental oxygen will be delivered at 4 L/min via nasal cannula to improve ventilatory control stability.
Oral appliance plus oxygen
Both treatments will be administered simultaneously.
No treatment
Subjects will not wear an oral appliance, and will be administered sham (room air) at 4 L/min via nasal cannula.
Sleep and Circadian Medicine Laboratory, BASE Facility, Monash University, Notting Hill
Brigham and Women's Hospital, Boston
Monash University
OTHER
American Heart Association
OTHER
National Heart, Lung, and Blood Institute (NHLBI)
NIH
Heart Foundation of Australia
UNKNOWN
Brigham and Women's Hospital
OTHER