Proton Beam or Intensity-Modulated Radiation Therapy in Preserving Brain Function in Patients With IDH Mutant Grade II or III Glioma

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

120

Participants

Timeline

Start Date

January 23, 2018

Primary Completion Date

June 1, 2026

Study Completion Date

June 1, 2027

Conditions
Anaplastic AstrocytomaAnaplastic OligoastrocytomaAnaplastic OligodendrogliomaDiffuse AstrocytomaGliomaOligoastrocytomaOligodendrogliomaWHO Grade 3 Glioma
Interventions
PROCEDURE

Biospecimen Collection

Undergo collection of blood samples

RADIATION

Intensity-Modulated Radiation Therapy

Undergo IMRT

OTHER

Laboratory Biomarker Analysis

Correlative studies

PROCEDURE

Magnetic Resonance Imaging

Undergo MRI

RADIATION

Proton Beam Radiation Therapy

Undergo proton beam radiation therapy

OTHER

Quality-of-Life Assessment

Ancillary studies

OTHER

Questionnaire Administration

Ancillary studies

DRUG

Temozolomide

Drug

Trial Locations (34)

10016

Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York

19104

University of Pennsylvania/Abramson Cancer Center, Philadelphia

21014

UM Upper Chesapeake Medical Center, Bel Air

21044

Central Maryland Radiation Oncology in Howard County, Columbia

21061

UM Baltimore Washington Medical Center/Tate Cancer Center, Glen Burnie

21201

Maryland Proton Treatment Center, Baltimore

University of Maryland/Greenebaum Cancer Center, Baltimore

30308

Emory Proton Therapy Center, Atlanta

Emory University Hospital Midtown, Atlanta

30322

Emory University Hospital/Winship Cancer Institute, Atlanta

33176

Miami Cancer Institute, Miami

33486

Boca Raton Regional Hospital, Boca Raton

35233

University of Alabama at Birmingham Cancer Center, Birmingham

44106

Case Western Reserve University, Cleveland

44129

University Hospitals Parma Medical Center, Parma

44266

University Hospitals Portage Medical Center, Ravenna

55905

Mayo Clinic in Rochester, Rochester

60134

Northwestern Medicine Cancer Center Delnor, Geneva

60555

Northwestern Medicine Cancer Center Warrenville, Warrenville

60611

Northwestern University, Chicago

63110

Washington University School of Medicine, St Louis

64064

University of Kansas Cancer Center - Lee's Summit, Lee's Summit

64116

University of Kansas Cancer Center at North Kansas City Hospital, North Kansas City

64154

University of Kansas Cancer Center - North, Kansas City

65804

Mercy Hospital Springfield, Springfield

66160

University of Kansas Cancer Center, Kansas City

66205

University of Kansas Hospital-Westwood Cancer Center, Westwood

66210

University of Kansas Cancer Center-Overland Park, Overland Park

73104

University of Oklahoma Health Sciences Center, Oklahoma City

77030

M D Anderson Cancer Center, Houston

98133

FHCC at Northwest Hospital, Seattle

98195

University of Washington Medical Center - Montlake, Seattle

04074

MaineHealth Maine Medical Center- Scarborough, Scarborough

02114

Massachusetts General Hospital Cancer Center, Boston

Sponsors

Lead Sponsor

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

NRG Oncology

OTHER