Cobimetinib (Targeted Therapy) Plus Atezolizumab (Immunotherapy) in Participants With Advanced Melanoma Whose Cancer Has Worsened During or After Treatment With Previous Immunotherapy and Atezolizumab Monotherapy in Participants With Previously Untreated Advanced Melanoma

PHASE1CompletedINTERVENTIONAL
Enrollment

155

Participants

Timeline

Start Date

June 20, 2017

Primary Completion Date

May 29, 2019

Study Completion Date

September 21, 2020

Conditions
Malignant Melanoma
Interventions
BIOLOGICAL

Atezolizumab

Atezolizumab, 840 mg intravenously every two weeks (Q2W) on Days 1 and 15 of each 28-day cycle, until loss of clinical benefit

DRUG

Cobimetinib

Cobimetinib, 60 mg orally once daily (QD) on Days 1-21 of each 28-day cycle, until loss of clinical benefit

BIOLOGICAL

Atezolizumab

Atezolizumab, 840 mg intravenously on Day 15 of Cycle 1; thereafter Q2W on Days 1 and 15 of Cycle 2 and all subsequent 28-day cycles, until loss of clinical benefit

BIOLOGICAL

Atezolizumab

Atezolizumab, 1200 mg intravenously every three weeks (Q3W) on Day 1 of each 21-day cycle, until loss of clinical benefit

Trial Locations (43)

1692

Johese Clinical Research, Centurion

2060

Melanoma Institute Australia, North Sydney

2148

Blacktown Hospital, Blacktown

2193

Wits Clinical Research; Charlotte Maxeke Johannesburg Academic Hospital, Johannesburg

2444

Mid North Coast Cancer Institute, Port Macquarie

3000

Peter Maccallum Cancer Centre, Melbourne

3004

Alfred Hospital, Melbourne

4120

Greenslopes Private Hospital; Clinic Pharmacy, Greenslopes

5042

Flinders Medical Centre, Bedford Park

6045

Cancercare, Port Elizabeth

6529

Cancercare, George

7570

Cape Town Oncology Trials, Cape Town

7800

GVI Constantiaberg, Cape Town

15706

Hospital Clinico Universitario de Santiago, Santiago de Compostela

28033

MD Anderson Cancer Center, Madrid

28034

Hospital Universitario Ramón y Cajal; Pharmacy, Madrid

28041

Hospital Universitario 12 de Octubre; Servicio de Oncologia, Madrid

28046

Hospital Universitario La Paz; Servicio de Oncologia, Madrid

31620

Clínica Universidad de Navarra, Pamplona

36022

National Cancer Institute MOH of Ukraine, Kiev

37203

Sarah Cannon Research Institute, Nashville

40005

Sumy Regional Clinical Onc Ctr, Sumy

41071

Hospital Universitario Virgen Macarena, Seville

48201

Karmanos Cancer Institute, Detroit

49102

Public Institution: City Multispecialty Clinical Hospital #4 under Dnipropetrovsk Regional Council, Dnipropetrovsk

63110

Washington University School of Medicine, St Louis

75231

Baylor University Medical Center, Dallas

78000

University Clinical Centre of the Republic of Srpska, Banja Luka

79031

Lviv State Oncology Regional Treatment and Diagnostic Centre, Lviv

80045

University of Colorado Hospital - Anschutz Cancer Pavilion, Aurora

85258

HonorHealth Research Institute - Bisgrove, Scottsdale

88017

Central Municipal Hospital - Uzhgorod State University, Uzhhorod

71 000

University Clinic Ctr Sarajevo, Sarajevo

60130-241

Instituto de Ensino e Pesquisa Clinica do Ceara, Fortaleza

30130-090

Cenantron - Centro Avancado de Tratamento Oncologico, Belo Horizonte

20560-120

Instituto Nacional de Cancer - INCa; Oncologia, Rio de Janeiro

99010-090

Hospital Sao Vicente de Paulo, Passo Fundo

90035-903

Hospital das Clinicas - UFRGS, Porto Alegre

90610-000

Hospital Sao Lucas - PUCRS, Porto Alegre

17210-120

Hospital Amaral Carvalho, Jaú

0002

Steve Biko Academic Hospital; Oncology, Pretoria

08028

Hospital Universitari Quiron Dexeus, Barcelona

08036

Hospital Clinic I Provincial, Barcelona

All Listed Sponsors
lead

Hoffmann-La Roche

INDUSTRY

NCT03178851 - Cobimetinib (Targeted Therapy) Plus Atezolizumab (Immunotherapy) in Participants With Advanced Melanoma Whose Cancer Has Worsened During or After Treatment With Previous Immunotherapy and Atezolizumab Monotherapy in Participants With Previously Untreated Advanced Melanoma | Biotech Hunter | Biotech Hunter