Enhancing Preventive Therapy of Malaria In Children With Sickle Cell Anemia in East Africa (EPiTOMISE)

PHASE4CompletedINTERVENTIONAL
Enrollment

246

Participants

Timeline

Start Date

January 23, 2018

Primary Completion Date

December 16, 2020

Study Completion Date

December 16, 2020

Conditions
Malaria,Falciparum
Interventions
DRUG

Proguanil Oral Tablet

Dosing of daily proguanil will be approximately 3mg/kg/day,

DRUG

Sulfadoxine/Pyrimethanine-Amodiaquine (SP-AQ)

Age 1-5 on Day 1: One tablet 500/25mg SP and one tablet 153mg AQ Day 2 and Day 3: one tablet 153 mg AQ only each day For ages 6-10: Day 1 - 1.5 tablets 500/25mg SP and 1.5 tablets 153mg AQ Days 2 and 3: 1.5 tablets 153mg AQ only each day

DRUG

Dihydroartemisinin-Piperaquine (DP)

"3\) The weight-based dosing of tablets of 40/320mg of DP is described below:~Weight (kg) No. of 40/320mg tabs DP daily for 3 days~≤ 5 ¼ 6-10 ½ 11-14 ¾ 15-19 1 20-23 1 ¼ 24-25 1 ½"

Trial Locations (1)

40300

Homa Bay County Referral Hospital, Homa Bay Town

Sponsors

Lead Sponsor

All Listed Sponsors
collaborator

National Heart, Lung, and Blood Institute (NHLBI)

NIH

lead

Duke University

OTHER