1,000
Participants
Start Date
September 22, 2017
Primary Completion Date
October 31, 2026
Study Completion Date
October 31, 2026
Alectinib
Participants will receive 600 mg BID (Cohort A); 900, 1200, or 750 mg BID (Cohort B) or RP2D BID; orally until disease progression, unacceptable toxicity, withdrawal of consent or death.
Atezolizumab
Participants will receive atezolizumab 1200 mg IV infusion Q21D (Cohorts C and F) or 1680 mg IV infusion Q4W starting on Day 29 (Cohort E).
Pemetrexed
Participants will receive pemetrexed 500 mg/m\^2 IV infusion on Day 1 Q21D.
Cisplatin
Participants will receive cisplatin 75 mg/m\^2 IV on Day 1 Q21D.
Carboplatin
Participants will receive carboplatin of AUC 5 or 6 IV on Day 1 Q21D.
Gemcitabine
Participants will receive gemcitabine 1000 or 1250 mg/m\^2 on Days 1 and 8 of every cycle (1 Cycle=21 days).
Entrectinib
Participants will receive entrectinib 600 mg orally QD.
Cobimetinib
Participants will receive 60 mg PO QD on Days 1-21 of the initial run-in and triple-combination periods.
Vemurafenib
Participants will receive 960 mg PO BID on Days 1-21 of the initial run-in period, and 720 mg PO BID on Days 22-28 of the initial run-in period and on Days 1-28 of each cycle during the triple-combination period.
Bevacizumab
Participants will receive 15 mg/kg of IV bevacizumab on Day 1 of each 21-day cycle during the induction and maintenance periods.
Divarasib
Participants will receive divarasib PO QD until disease progression or unacceptable toxicity.
Docetaxel
Participants will receive IV docetaxel Q3W (75 mg/m\^2) until disease progression or unacceptable toxicity
Hospital Nacional Edgardo Rebagliati Martins, Lima
National Taiwan Uni Hospital, Taipei
Taipei Veterans General Hospital, Taipei
Chang Gung Medical Foundation - Linkou, Taoyuan District
Auckland City Hospital, Auckland
UZ Brussel, Brussels
Royal North Shore Hospital, St Leonards
UZ Leuven Gasthuisberg, Leuven
The Prince Charles Hospital, Chermside
Ashford Cancer Center Research, Kurralta Park
Weill Cornell Medical College-New York Presbyterian Hospital, New York
Azienda Sanitaria Ospedaliera S Luigi Gonzaga, Orbassano (TO)
Chulalongkorn Hospital, Bangkok
Ramathibodi Hospital, Bangkok
National Cancer Center, Gyeonggi-do
Montefiore Medical Center, The Bronx
Faculty of Med. Siriraj Hosp., Bangkok
Clinical Center of Serbia, Belgrade
University Hospital Medical Center Bezanijska kosa, Belgrade
Instituto Nacional de Enfermedades Neoplasicas, Lima
Complejo Hospitalario Universitario de Santiago (CHUS), Santiago de Compostela
Clinical Center Nis, Niš
St. Luke's University Health network, Bethlehem
Irccs Istituto Europeo di Oncologia (IEO), Milan
Asst Di Monza, Monza
Hospital Angeles Tijuana, Tijuana
Trakya University Medical Faculty Research And Practice Hospital Medical Oncology Department, Edirne
Asst Papa Giovanni XXIII, Bergamo
ASST di Cremona - Azienda Socio Sanitaria Territoriale di Cremona, Cremona
Hospital General Universitario Gregorio Marañon, Madrid
Hospital Ramon y Cajal, Madrid
Hospital Universitario 12 de Octubre, Madrid
Centro Integral Oncologico Clara Campal, Madrid
Hospital Universitario Puerta de Hierro, Madrid
Hospital Quiron de Madrid, Madrid
Hospital Regional Universitario Carlos Haya, Málaga
Hopital Caremeau, Nîmes
Clinica Universitaria de Navarra, Pamplona
CHU de Toulouse - Hôpital Larrey, Toulouse
Irccs Centro Di Riferimento Oncologico (CRO), Aviano
Florida Cancer Specialist, North Region, St. Petersburg
SCRI Florida Cancer Specialists South, Fort Myers
Medipol University Medical Faculty; Oncology Department, Istanbul
Marmara University Pendik Training and Research Hospital; Medikal Onkoloji, Istanbul
Hopital Pontchaillou, Rennes
Medikal Park Izmir Hospital, Kar??yaka
Sarah Cannon Research Institute / Tennessee Oncology, Nashville
Sarah Cannon Research Institute / Tennessee Oncology, Chattanooga
University of Kentucky, Lexington
Hospital Universitario Virgen del Rocio, Seville
Hospital Clínico Universitario de Valencia, Valencia
IRST Istituto Scientifico Romagnolo Per Lo Studio E Cura Dei Tumori, Sede Meldola, Meldola
Chonnam National University Hwasun Hospital, Jeollanam-do
Centre Oscar Lambret, Lille
AVIX Investigación Clínica S.C, Monterrey
HSK Dr.-Horst-Schmidt-Kliniken Klinik für Innere Medizin III Onkologie Hämatologie und Palliativmed, Wiesbaden
Thoraxklinik Heidelberg gGmbH, Heidelberg
Centre Léon Bérard, Lyon
Klinikum Esslingen, Esslingen am Neckar
Hôpital Européen Georges Pompidou, Paris
Hopital Tenon, Paris
Oncologico Potosino, San Luis Potosí City
Istituto Nazionale per lo Studio e la Cura dei Tumori Fondazione G. Pascale, Napoli
Rocky Mountain Cancer Center, Denver
Asklepios-Fachklinik Muenchen-Gauting, Gauting
Kaohsiung Chang Gung Memorial Hospital, Kaohsiung City
CHU Poitiers, Poitiers
Comprehensive Cancer Centers of Nevada, Las Vegas
Prince of Songkla University, Hat Yai
UC Davis, Sacramento
Oregon HSU, Portland
Beijing Cancer Hospital, Beijing
Principal Military Clinical Hospital n.a. N.N. Burdenko, Moscow
National University Hospital, Singapore
Moscow City Oncology Hospital #62, Moscovskaya Oblast
National Cancer Centre, Singapore
S-Pb clinical scientific practical center of specialized kinds of medical care (oncological), Saint Petersburg
Fudan Unviversity Shanghai Cancer Center, Shanghai
Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, Nanjing
Shandong Cancer Hospital, Jinan
Zhejiang Cancer Hospital, Hangzhou
The Second Affiliated Hospital to Nanchang University, Nanchang
Hunan Cancer Hospital, Changsha
The second Xiangya hospital of central south university, Changsha
The First Affiliated Hospital of Guangzhou Medical University Pharmacy, Guangzhou
Sichuan Cancer Hospital, Chengdu
West China Hospital - Sichuan University, Chengdu
Clinical Oncology Dispensary, Omsk
First Affiliated Hospital of Medical College of Xi'an Jiaotong University, Xi'an
Rambam Health Care Campus, Haifa
Meir Medical Center, Kfar Saba
Rabin MC, Petah Tikva
Chaim Sheba Medical Center, Ramat Gan
Sourasky / Ichilov Hospital; Dept. of Oncology, Tel Aviv
Soroka Medical Center, Beersheba
Bradford Hill Centro de Investigaciones Clinicas, Recoleta
Dartmouth Hitchcock Medical Center, Lebanon
Fundación CENIT para la Investigación en Neurociencias, Buenos Aires
Hospital Italiano, Buenos Aires
Hospital Britanico de Buenos Aires, Ciudad Autonoma Buenos Aires
Oncosite - Centro de Pesquisa Clinica Em Oncologia Ltda, Ijuí
Hospital Sao Lucas - PUCRS, Porto Alegre
Instituto do Cancer do Estado de Sao Paulo - ICESP, São Paulo
Cross Cancer Institute, Edmonton
CancerCare Manitoba, Winnipeg
Royal Victoria Regional Health Centre, Barrie
William Osler Health System Brampton Civic Hospital, Brampton
London Health Sciences Centre · Victoria Hospital, London
Lakeridge Health Center, Oshawa
Sunnybrook Health Sciences Centre, Toronto
Princess Margaret Cancer Center, Toronto
Jewish General Hospital, Montreal
IUCPQ (Hôpital Laval), Québec
Saskatoon Cancer Centre, Saskatoon
Klinikum Chemnitz gGmbH, Chemnitz
Queen Mary Hospital, Hong Kong
Prince of Wales Hosp, Shatin
Instituto Peruano de Oncología y Radioterapia, Lima
Azienda Ospedaliera San Camillo Forlanini, Rome
Tokyo Metropolitan Cancer and Infectious diseases Center Komagome Hospital, Bunkyō City
National Hospital Organization Kyushu Medical Center, Fukuoka
National Hospital Organization Kyushu Cancer Center, Fukuoka
Kyushu University Hospital, Fukuoka
Hiroshima University Hospital, Hiroshima
Kanazawa University Hospital, Ishikawa
Kanagawa Cancer Center, Kanagawa
University Hospital Kyoto Prefectural University of Medicine, Kyoto
Shikoku Cancer Center, Matsuyama
Tohoku University Hospital, Miyagi
Sendai Kousei Hospital, Miyagi
Niigata University Medical & Dental Hospital, Niigata
Niigata Cancer Center Hospital, Niigata
Kindai University Hospital, Osaka
Saga University Hospital, Saga
Shizuoka Cancer Center, Shizuoka
Juntendo University Hospital, Tokyo
The Cancer Institute Hospital of JFCR, Tokyo
Kyorin University Hospital, Tokyo
Fujita Health University Hospital, Toyoake-shi
Wakayama Medical University Hospital, Wakayama
National Hospital Organization Yamaguchi - Ube Medical Center, Yamaguchi
Health Pharma Professional Research, Mexico City
Hemato Oncología de Panamá Especializada, Panama City
Clinica Ricardo Palma, San Isidro
Uniwersyteckie Centrum Kliniczne, Klinika Onkologii i Radioterapii, Gda?sk
Krakowski Szpital Specjalistyczny im sw.Jana Pawla II, Krakow
Warminsko-Mazurskie Centrum Chorób P?uc w Olsztynie, Olsztyn
Mazowieckie Centrum Leczenia Chorob Pluc I Gruzlicy, Otwock
Wielkopolskie Centrum Pulmonologii i Torakochirurgii w Poznaniu, Poznan
Centrum Onkologii Instytut im.Marii Sklodowskiej-Curie, Warsaw
Seoul National University Hospital, Seoul
Asan Medical Center, Seoul
Yonsei University Health System/Severance Hospital, Seoul
Insititut Catala D'Oncologia, L'Hospitalet de Llobregat
Hospital General Univ. de Alicante, Alicante
Hospital Universitari Vall d'Hebron, Barcelona
Hospital Clínic i Provincial, Barcelona
ICO Badalona - Hospital Germans Trias i Pujol, Barcelona
Baskent University Adana Dr. Turgut Noyan Practice and Research Hospital; Medical Oncology, Adana
Akdeniz University Medical Faculty; Medical Oncology Department, Antalya
Hacettepe Uni Medical Faculty Hospital; Oncology Dept, Sihhiye/Ankara
Hoffmann-La Roche
INDUSTRY