Study of Evinacumab (REGN1500) in Participants With Persistent Hypercholesterolemia

PHASE2CompletedINTERVENTIONAL
Enrollment

272

Participants

Timeline

Start Date

November 10, 2017

Primary Completion Date

May 22, 2020

Study Completion Date

December 14, 2020

Conditions
Hypercholesterolemia
Interventions
DRUG

Evinacumab

SC or IV administration

DRUG

Matching placebo

SC or IV administration

OTHER

Background Lipid Modifying Therapy (LMT)

All participants should be on a stable, maximally tolerated statin throughout the duration of the study. The dose of statin and of PCSK9 inhibitor, such as alirocumab or evolocumab, as well as other LMT (if applicable), should remain stable throughout the study duration, from screening through the end of study (EOS) visit.

Trial Locations (95)

182

Jongaie Research, Pretoria

713

Dr JM Engelbrecht Trial Site, Cape Town

1020

Redcliffe Hospital, Redcliffe

2000

The Charlotte Maxeke Johannesburg Academic Hospital, Johannesburg

2050

Royal Prince Alfred Hospital, Camperdown

3112

Clinical Horizons NZ Ltd, Tauranga

3118

Papamoa Pines Medical Centre, Papamoa

6020

University Hospital Innsbruck - Tyrolean Hospital, Innsbruck

6700

Sydvestjysk Sygehus, Esbjerg

7400

Regionshospitalet Herning, Herning

7500

TREAD Research CC, Parow

7925

University of Cape Town, Cape Town

8011

Lipid and Diabetes Research Group, Christchurch

10029

Mt Sinai Ichan Medical Institute, New York

11184

Istishari Hospital, Amman

11446

Akardo MedSite, Stockholm

13000

CCR Prague, S.R.O, Prague

14004

Hospital Universitario Reina Sofia, Córdoba

14021

Ikem Institut Klinicke A Experimentalni Mediciny, Prague

15001

Hospital Universitario A Coruna, A Coruña

17011

Capital Area Research, LLC, Camp Hill

18014

Hospital Universitario Virgen de las Nieves (HUVN), Granada

21079

Houpital Du Bocage, Dijon

21201

University of Maryland School of Medicine, Baltimore

22110

King Abdullah University Hospital-1, Irbid

King Abdullah University Hospital-2, Irbid

King Abdullah University Hospital, Irbid

27710

Duke University Medical Center, Durham

28144

Rowan Diagnostic Clinic, Salisbury

32792

Florida Lipid Institute, Winter Park

33166

Care Research Center Inc, Doral

33434

Preventive Cardiology Inc, Boca Raton

34012

Cardiology Research Institute, Tomsk

34406

Municipal Medical and Prophylactic Institution - City Hospital for Emergency Care No.2, Rostov-on-Don

41013

Hospital Universitario Virgen del Rocio, Seville

41709

Nzoz Przychodnia Specjalistyczna, Ruda Slaska

44000

Hopital G Et R Laennec, Nantes

46290

St. Vincent Medical Group, Inc, Indianapolis

47923

Ausl Della Romagna-Ospedale Degli Infermi, Rimini

49546

Heart Health Cardiology, Grand Rapids

50008

University Hospital, Charles University, Hradec Králové

50009

Hospital Universitario Miguel Servet, Zaragoza

55407

Minneapolis Heart Institute Foundation, Minneapolis

55455

University of Minnesota, Minneapolis

56126

Fondazione Toscana Gabriele Monasterio Per La Ricerca Medica E Di Sanita Pubblica, Pisa

58100

Edith Wolfson Medical Center, Holon

63110

Washington University School of Medicine, St Louis

64239

Sourasky Medical Center, Cardiovascular Research Center, Tel Aviv

65000

Federal State Budgetary Institution Research Institute for Complex Issues of Cardiovacsular Disease, Kemerovo

66160

University of Kansas Medical Center, Kansas City

75185

Akademiska sjukhuset, Uppsala

75701

PharmaTex Research, Tyler

77030

The University Of Texas Health Science Center Houston, Houston

78154

Clear Clinical Research, LLC, Schertz

78220

San Antonio Premiere Internal Medicine, San Antonio

80131

Azienda Ospedaliero Universitaria Federico II di Napoli, Napoli

84107

Wasatch Clinical Research, Salt Lake City

90048

Cedars-Sinai Medical Center, Los Angeles

119990

National Research Center For Preventative Medicine of Federal Agency of High Technology Medical Aid, Moscow

129090

Federal State Budget Institution Out-patient Clinic 3, Moscow

191186

Limmited Liability Company International Medical Centre SOGAZ, Saint Petersburg

194291

Federal State Institution of Healthcare Clinical Hospital #122 N.A.L.G Sokolov, Saint Petersburg

196084

LLC- Institute of Medical Research, Saint Petersburg

197110

Federal State Budgetary Institution Clinical-Diagnostic Center with Polyclinic, Saint Petersburg

443070

Samara Regional Clinical Cardiologic Dispensary, Samara

630089

NII of Therapy and Preventive Medicine, Novosibirsk

5265601

Sheba Mc, Ramat Gan

92663-3668

Office of Dr. John D Homan MD, Newport Beach

04401

EMMC Northeast Cardiology Assocites, Bangor

02114

Massachusetts General Hospital, Boston

A-8036

Medizinische Universitaetsklinik Graz, Graz

N6A 5B7

Robarts Research Institute, London

L3Y 5G8

SKDS Research Inc., Newmarket

G7H 7K9

Centre Etudes Cliniques Econogene-21, Chicoutimi

G1V 4W2

Clinique des maladies lipidiques de Quebec, Québec

121 08

Univerzita Karlova v Praze 1 Lekarska Fakulta, Karlov

Unknown

Galilee Medical Center, Nahariya

Universitair Medisch Centrum Utrech - Locatie AZU, Utrecht

Wojewodzki Szpital Specjalistyczny, Bytom

Karolinska University Hospital, Malmo

00185

Dipartimento di Medicina Traslazionale e di Precisione dell'Università degli Studi di, Rome

103-0027

Tokyo-Eki Center-building Clinic, Chūōku

251-0041

Shonan Fujisawa Tokushukai Hospital, Fujisawa-shi

192-0918

Minamino Cardiovascular Hospital, Hachiōji

350-0495

Saitama Medical University Hospital, Iruma-gun

1624 NP

VOC Hoorn, Hoorn

4462 RA

Admiraal de Ruyter Ziekenhuis, Goes

1105 AZ

Academic Medical Center, Amsterdam

0373

M3 Helse AS, Oslo

58-130

Halina Serafin NZOZ Centrum Medyczne SERAFIN-MED, Żarów

41-800

Slaskie Centrum Chorob Serca, III Katedra i Oddzial Kliniczny Kardiologii SUM- Oddzial Chorob Serca i Naczyn, Zabrze

08907

Hospital Universitario de Bellvitge, Barcelona

SE-182 88

Karolinska Institutet, Stockholm

NW3 2QG

Royal Free Hospital-Royal Free London NHS Foundation Trust, London

NE1 4LP

Royal Victoria Infirmary - The Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne

All Listed Sponsors
lead

Regeneron Pharmaceuticals

INDUSTRY

NCT03175367 - Study of Evinacumab (REGN1500) in Participants With Persistent Hypercholesterolemia | Biotech Hunter | Biotech Hunter