Study of Cabozantinib Alone or in Combination With Atezolizumab to Subjects With Locally Advanced or Metastatic Solid Tumors

PHASE1Active, not recruitingINTERVENTIONAL
Enrollment

914

Participants

Timeline

Start Date

September 5, 2017

Primary Completion Date

February 21, 2023

Study Completion Date

September 30, 2027

Conditions
Urothelial CarcinomaRenal Cell CarcinomaNon-Small Cell Lung CancerCastration-resistant Prostate CancerTriple Negative Breast CancerOvarian CancerEndometrial CancerHepatocellular CarcinomaGastric CancerGastroesophageal Junction AdenocarcinomaColorectal CancerHead and Neck CancerDifferentiated Thyroid CancerLower Esophageal Cancer
Interventions
DRUG

cabozantinib

Supplied as 60-mg and 20-mg tablets; administered orally daily at dose levels of 20 mg, 40 mg, or 60 mg.

DRUG

atezolizumab

Supplied as 1200-mg vials; administered as an IV infusion once every 3 weeks (q3w).

DRUG

cabozantinib

Supplied as 60-mg and 20-mg tablets; administered orally daily at the Cohort Review Committee-determined recommended dose from the Dose Escalation Stage

DRUG

cabozantinib

Supplied as 60-mg and 20-mg tablets; administered orally daily at 60 mg qd

Trial Locations (124)

2031

Exelixis Clinical Site #123, Randwick

2050

Exelixis Clinical Site #101, Camperdown

2109

Exelixis Clinical Site #112, North Ryde

2250

Exelixis Clinical Site #115, Gosford

2640

Exelixis Clinical Site #98, Albury

3000

Exelixis Clinical Site #54, Leuven

3021

Exelixis Clinical Site #99, St Albans

9000

Exelixis Clinical Site #52, Ghent

10029

Exelixis Clinical Site #11, New York

10461

Exelixis Clinical Site #37, The Bronx

11407

Exelixis Clinical Site #96, Jeréz de La Frontera

11733

Exelixis Clinical Site #40, East Setauket

13273

Exelixis Clinical Site #109, Marseille

14076

Exelixis Clinical Site #87, Caen

15232

Exelixis Clinical Site #66, Pittsburgh

15706

Exelixis Clinical Site #74, Santiago de Compostela

17007

Exelixis Clinical Site #118, Girona

18015

Exelixis Clinical Site #41, Bethlehem

19107

Exelixis Clinical Site #15, Philadelphia

19111

Exelixis Clinical Site #55, Philadelphia

20007

Exelixis Clinical Site #48, Washington D.C.

20089

Exelixis Clinical Site #47, Rozzano

20132

Exelixis Clinical Site #108, Milan

20133

Exelixis Clinical Site #103, Milan

Exelixis Clinical Site #25, Milan

Exelixis Clinical Site #4, Milan

22908

Exelixis Clinical Site #14, Charlottesville

24060

Exelixis Clinical Site #30, Blacksburg

27100

Exelixis Clinical Site #121, Pavia

28034

Exelixis Clinical Site #77, Madrid

28040

Exelixis Clinical Site #106, Madrid

Exelixis Clinical Site #111, Madrid

28041

Exelixis Clinical Site #22, Madrid

Exelixis Clinical Site #5, Madrid

28046

Exelixis Clinical Site #81, Madrid

29010

Exelixis Clinical Site #100, Málaga

29229

Exelixis Clinical Site #93, Brest

29414

Exelixis Clinical Site #95, Charleston

30029

Exelixis Clinical Site #80, Nîmes

30318

Exelixis Clinical Site #60, Atlanta

30341

Exelixis Clinical Site #79, Atlanta

31008

Exelixis Clinical Site #90, Pamplona

32224

Exelixis Clinical Site #16, Jacksonville

33011

Exelixis Clinical Site #94, Oviedo

33076

Exelixis Clinical Site #92, Bordeaux

33612

Exelixis Clinical Site #76, Tampa

35760

Exelixis Clinical Site #82, Saint-Grégoire

38320

Exelixis Clinical Site #117, San Cristóbal de La Laguna

40225

Exelixis Clinical Site #56, Düsseldorf

40536

Exelixis Clinical Site #57, Lexington

43210

Exelixis Clinical Site #49, Columbus

44195

Exelixis Clinical Site #67, Cleveland

45409

Exelixis Clinical Site #64, Kettering

47014

Exelixis Clinical Site #84, Meldola

48201

Exelixis Clinical Site #3, Detroit

54519

Exelixis Clinical Site #105, Vandœuvre-lès-Nancy

55905

Exelixis Clinical Site #17, Rochester

59000

Exelixis Clinical Site #97, Lille

60426

Exelixis Clinical Site #32, Harvey

64111

Exelixis Clinical Site #43, Kansas City

65613

Exelixis Clinical Site #65, Bolivar

66205

Exelixis Clinical Site #23, Fairway

67000

Exelixis Clinical Site #119, Strasbourg

68130

Exelixis Clinical Site #35, Omaha

Exelixis Clinical Site #59, Omaha

69373

Exelixis Clinical Site #89, Lyon

70112

Exelixis Clinical Site #24, New Orleans

72000

Exelixis Clinical Site #69, Le Mans

72076

Exelixis Clinical Site #36, Tübingen

73104

Exelixis Clinical Site #71, Oklahoma City

73120

Exelixis Clinical Site #6, Oklahoma City

75005

Exelixis Clinical Site #78, Paris

75010

Exelixis Clinical Site #7, Paris

75013

Exelixis Clinical Site #68, Paris

75015

Exelixis Clinical Site #72, Paris

75246

Exelixis Clinical Site #13, Dallas

75390

Exelixis Clinical Site #26, Dallas

76104

Exelixis Clinical Site #114, Fort Worth

77030

Exelixis Clinical Site #29, Houston

Exelixis Clinical Site #39, Houston

Exelixis Clinical Site #44, Houston

78229

Exelixis Clinical Site #63, San Antonio

79410

Exelixis Clinical Site #33, Lubbock

80131

Exelixis Clinical Site #85, Napoli

80218

Exelixis Clinical Site #34, Denver

Exelixis Clinical Site #50, Denver

84112

Exelixis Clinical Site #2, Salt Lake City

85054

Exelixis Clinical Site #18, Phoenix

85234

Exelixis Clinical Site #53, Gilbert

85925

Exelixis Clinical Site #88, La Roche-sur-Yon

89169

Exelixis Clinical Site #61, Las Vegas

90025

Exelixis Clinical Site #46, Los Angeles

90404

Exelixis Clinical Site #62, Santa Monica

91010

Exelixis Clinical Site #1, Duarte

92090

Exelixis Clinical Site #20, La Jolla

92150

Exelixis Clinical Site #107, Suresnes

92663

Exelixis Clinical Site #51, Newport Beach

94305

Exelixis Clinical Site #21, Stanford

94805

Exelixis Clinical Site #8, Villejuif

97213

Exelixis Clinical Site #102, Portland

97239

Exelixis Clinical Site #45, Portland

06511

Exelixis Clinical Site #42, New Haven

02215

Exelixis Clinical Site #10, Boston

08103

Exelixis Clinical Site #38, Camden

08816

Exelixis Clinical Site #27, East Brunswick

08903

Exelixis Clinical Site #31, New Brunswick

06189

Exelixis Clinical Site #104, Nice

00168

Exelixis Clinical Site #110, Roma

6525 GA

Exelixis Clinical Site #12, Nijmegen

03203

Exelixis Clinical Site #91, Elche

07120 / 07010

Exelixis Clinical Site #70, Palma de Mallorca

08916

Exelixis Clinical Site #113, Badalona

08208

Exelixis Clinical Site #116, Sabadell

08003

Exelixis Clinical Site #75, Barcelona

08022

Exelixis Clinical Site #58, Barcelona

08023

Exelixis Clinical Site #83, Barcelona

08025

Exelixis Clinical Site #86, Barcelona

08035

Exelixis Clinical Site #28, Barcelona

Exelixis Clinical Site #9, Barcelona

08036

Exelixis Clinical Site #73, Barcelona

HA6 2RN

Exelixis Clinical Site #122, Middlesex

PR2 9HT

Exelixis Clinical Site #120, Preston

CF14 2TL

Exelixis Clinical Site #124, Cardiff

EC1M 6BQ

Exelixis Clinical Site #19, London

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Exelixis

INDUSTRY