REstricted Versus Liberal Positive End-Expiratory Pressure in Patients Without ARDS

NACompletedINTERVENTIONAL
Enrollment

980

Participants

Timeline

Start Date

October 26, 2017

Primary Completion Date

January 14, 2020

Study Completion Date

March 16, 2020

Conditions
Ventilator-free Days
Interventions
PROCEDURE

restricted PEEP

Patients are randomized and ventilated with restricted PEEP (the lowest possible PEEP level, 0 - 5 cm H2O)

PROCEDURE

liberal PEEP

Patients are randomized and ventilated with liberal PEEP (the median PEEP level used in the Netherlands, 8 cm H2O)

Trial Locations (13)

Unknown

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA), Amsterdam

Onze Lieve Vrouwe Gasthuis, Amsterdam

VU Medical Center, Amsterdam

Gelre Hospital, Apeldoorn

Rijnstate, Arnhem

Amphia Hospital, Breda

Spaarne Gasthuis, Hoofddorp

Westfriesgasthuis, Hoorn

Maastricht University Medical Center, Maastricht

Sint Antonius Hospital, Nieuwegein

Haaglanden Medical Center, The Hague

HagaZiekenhuis, The Hague

Isala Clinics, Zwolle

All Listed Sponsors
collaborator

ZonMw: The Netherlands Organisation for Health Research and Development

OTHER

collaborator

Amphia Hospital

OTHER

collaborator

Gelre Hospitals

OTHER

collaborator

Isala

OTHER

collaborator

Maastricht University Medical Center

OTHER

collaborator

Medical Center Haaglanden

OTHER

collaborator

Onze Lieve Vrouwe Gasthuis

OTHER

collaborator

St. Antonius Hospital

OTHER

collaborator

Amsterdam UMC, location VUmc

OTHER

collaborator

Dijklander Ziekenhuis

OTHER

collaborator

Spaarne Gasthuis

OTHER

collaborator

HagaZiekenhuis

OTHER

collaborator

Rijnstate Hospital

OTHER

lead

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

OTHER

NCT03167580 - REstricted Versus Liberal Positive End-Expiratory Pressure in Patients Without ARDS | Biotech Hunter | Biotech Hunter