46
Participants
Start Date
December 20, 2017
Primary Completion Date
March 16, 2019
Study Completion Date
December 28, 2019
bone marrow-derived MSC and HRT
"* Transplantation procedure to endometrial cavity is performed with ultrasound guidance on menstrual cycle day 5-6 through uterine cervix using cater for embryo transfer with 1 ml of suspension containing 5 millions of autologous bone marrow-derived mesenchymal stem cells~* Three cycles of HRT following MSC transplantation;~* Pipelle-biopsy of endometrium on day 20 of hormonal replacement therapy of the last (third) cycle;~* Frozen/thawed embryo transfer 3-6 months after transplantation."
hormonal replacement therapy
"standard treatment of hypoplastic endometrium or Asherman's syndrome:~* Three cycles of HRT preceding frozen/thawed embryo transfer;~* Frozen/thawed embryo transfer."
D.O. Ott Research Institute of Obstetrics, Gynecology, and Reproductology, Saint Petersburg
D.O. Ott Research Institute of Obstetrics, Gynecology, and Reproductology
OTHER