Tralokinumab Monotherapy for Moderate to Severe Atopic Dermatitis - ECZTRA 2 (ECZema TRAlokinumab Trial no. 2)

PHASE3CompletedINTERVENTIONAL
Enrollment

794

Participants

Timeline

Start Date

June 12, 2017

Primary Completion Date

September 4, 2018

Study Completion Date

August 14, 2019

Conditions
Atopic Dermatitis
Interventions
DRUG

Tralokinumab

Tralokinumab is a human recombinant monoclonal antibody of the IgG4 subclass that specifically binds to human IL-13 and blocks interaction with the IL-13 receptors. It is presented as a liquid formulation for subcutaneous (SC) administration

DRUG

Placebo

Placebo contains the same excipients, in the same concentration only lacking tralokinumab

Trial Locations (115)

2010

Skin & Cancer Foundation Australia, Darlinghurst

2217

St. George Dermatology and Skin Cancer Center, Kogarah

2606

Woden Dermatology Pty Ltd., Phillip

3002

Sinclair Dermatology, East Melbourne

3053

Skin & Cancer Foundation Inc., Carlton

4102

Veracity Clinical Research, Woolloongabba

6100

Burswood Dermatology, Victoria Park

10029

Icahn School of Medicine at Mount Sinai, New York

10075

Sadick Dermatology, New York

14584

Soon Chun Hyang University Hospital, Gyeonggi-do

14830

Corning Center for Clinical Research, Corning

19067

Yardley Dermatology Associates, Yardley

19103

Paddington Testing Company, Inc., Philadelphia

20089

Istituto Clinico Humanitas, Rozzano

21431

St. Mary's Hospital, Incheon

22332

Inha University Hospital, Incheon

25123

Spedali Civili Brescia, Brescia

27157

Wake Forest University Health Sciences, Winston-Salem

29407

Clinical Research Center of the Carolinas, Charleston

30060

Marietta Dermatology Clinical Research, Inc., Marietta

30263

MedaPhase, Inc., Newnan

33162

Private Practice - Dr. Tory P. Sullivan, North Miami Beach

33176

Spotlight Research Center, LLC, Miami

33756

Olympian Clinical Research, Clearwater

35015

Chungnam National Univeristy, Daejeon

37072

Rivergate Dermatology Clinical Research Center, Goodlettsville

43082

Aventiv Research Inc., Westerville

45267

University of Cincinnati Health Physicians Office, Cincinnati

45324

Wright State Physicians, Fairborn

46256

Dawes-Fretzin Clinical Research Group, LLC, Indianapolis

48088

The Grekin Skin Institute, Warren

48197

Respiratory Medicine Research Institute of Michigan, PLC, Ypsilanti

48202

HFMC New Center One, Detroit

49241

Pusan National University Hospital, Busan

56126

AOU Pisa, Pisa

60611

Northwestern University, Chicago

60612

RUSH University, Chicago

61469

Chonnam National University Hospital, Gwangju

66215

Kansas City Dermatology, PA, Overland Park

67100

Opedale San Salvatore, L’Aquila

71913

Burke Pharmaceutical Research, Hot Springs

75231

Modern Research Associates, PLLC, Dallas

77401

Bellaire Dermatology Associates, Bellaire

78213

Progressive Clinical Research, San Antonio

78660

Austin Institute for Clinical Research, Inc., Pflugerville

89074

Clinical Studies Group, Henderson

90033

USC Department of Dermatology, Los Angeles

92024

California dermatology, Encinitas

92123

Therapeutics Clinical Research, San Diego

92562

Thiele Dermatology Specialists, Inc, Murrieta

92660

Island Dermatology, Newport Beach

92701

Southern California Dermatology, Inc., Santa Ana

92835

Advanced SkinCare Surgery & Med Center, Fullerton

93405

San Luis Dermatology and Laser Clinic, San Luis Obispo

95123

Policlinico-Vittorio Emanuele, Catania

97210

Oregon Dermatology and Research Center, Portland

107076

Federal State Budgetary Institution State Sci. Ctr., Moscow

191123

French clinic of skin diseases, Saint Petersburg

194044

Military Medical Academy, Saint Petersburg

454048

Chelyabinsk Dermat. Dispensary, Chelyabinsk

02169

Beacon Clinical Research, Quincy

08520

Psoriasis Treatment Center of Central New Jersey, East Windsor

V3R 6A7

Dr. Chih-ho Hong Medical, Surrey

V3V 0C6

Enverus Medical Research, Surrey

V6H 4E1

Pacific Derm, Vancouver

R3C 0N2

Winnipeg Clinic, Winnipeg

R3M 3Z4

Wiseman Dermatology Research, Winnipeg

E3B 1G9

Brunswick Dermatology Centre, Fredericton

A1A 5E8

Nexus Clinical Research, St. John's

B5H 1Z4

Eastern Canada Cutaneous Research, Halifax

M8X 1Y9

Kingsway Clinical Research, Etobicoke

N6A 3H7

Guenther Derm Research Centre, London

L3P 1X2

Lynderm Research Inc., Markham

L5H 1G9

DermEdge Research, Mississauga

P1B 3Z7

Dermatology & Cosmetic Surgery, North Bay

K2G 6E2

Derm Clinic of Dr. Robern, Ottawa

K9J 5K2

Skin Centre for Dermatology, Peterborough

L4B 1A5

Dermatology & Cosmetic Surgery, Richmond Hill

N2J 1C4

K. Papp, Waterloo

N8W 1E6

XLR8 Medical Research, Windsor

H3H 1V4

Dr. David Gratton Dermatologue, Montreal

G1V 4X7

CRDQ, Québec

Unknown

Aarhus University Hospital, Aarhus

Bispebjerg Hospital, Hellerup

Gentofte Hospital, Hellerup

00144

IRCCS San Gallicano, Rome

00168

"Policlinico Agostino Gemelli", Rome

81-338

Centrum Medyczne Gdynia, Gdynia

81-384

Synexus Polska Gdyni, Gdynia

40-040

Synexus Polska Katowicach, Katowice

30-002

Centrum Medyczne PRATIA, Krakow

31-501

Krakowskie Centrum Medyczne, Krakow

90-265

"DERMED Centrum Medyczne Sp.", Lodz

90-436

Dermoklinika Centrum Medyczne, Lodz

60-702

Synexus Polska Poznaniu, Poznan

35-055

Klinika Dermatologii, Rzeszów

425-707

Korea University Ansan Hospital, Gyeonggi-do

03080

Seoul National University Hospital, Seoul

03722

Yonsei University Health Syste, Seoul

05030

Konkuk University Medical Center, Seoul

06973

Chung-Ang University Hospital, Seoul

07441

Hallym University Kangnam Sacr, Seoul

DD2 1GZ

Ninewells Hospital, Dundee

M6 8HD

Salford Royal Hospital, Salford

E11 1NR

Whipps Cross University Hospital, Leytonstone

HG2 7SX

Harrogate District Hospital, Harrogate

S10 2RX

Royal Hallamshire Hospital, Sheffield

RH1 5RH

East Surrey Hospital, Redhill

NE1 4LP

Royal Victoria Infirmary, Newcastle upon Tyne

DY1 2HQ

Russells Hall Hospital, Dudley

WS2 9PS

Walsall Healthcare NHS Trust, Walsall

LS7 4SA

Chapel Allerton Hospital, Leeds

IP33 2QZ

West Suffolk Hospital, Bury St Edmunds

N19 5NF

The Whittington Hospital NHS, London

SE1 9RT

Guy's Hospital, London

Sponsors

Lead Sponsor

All Listed Sponsors
lead

LEO Pharma

INDUSTRY