A Study of Selpercatinib (LOXO-292) in Participants With Advanced Solid Tumors, RET Fusion-Positive Solid Tumors, and Medullary Thyroid Cancer (LIBRETTO-001)

PHASE1/PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

857

Participants

Timeline

Start Date

May 2, 2017

Primary Completion Date

February 14, 2025

Study Completion Date

February 28, 2027

Conditions
Non-Small Cell Lung CancerMedullary Thyroid CancerColon CancerAny Solid Tumor
Interventions
DRUG

LOXO-292

Oral LOXO-292

Trial Locations (85)

2065

Royal North Shore Hospital, St Leonards

2200

Rigshospitalet, Copenhagen

3000

Peter MacCallum Cancer Centre, Melbourne

6000

Kantonsspital Luzern, Lucerne

8035

Hospital Universitari Vall d'Hebron, Barcelona

10002

National Taiwan University Hospital, Taipei

10016

NYU Langone, New York

10065

Memorial Sloan Kettering Cancer Center, New York

10408

National Cancer Center, Goyang-si

13385

APHM Hôpital de la Timone, Marseille

13620

Seoul National University Bundang Hospital, Seongnam

14263

Roswell Park Cancer Institute, Buffalo

19104

University of Pennsylvania Hospital, Philadelphia

19107

Thomas Jefferson University, Philadelphia

20133

Istituto Nazionale dei Tumori, Milan

21201

University of Maryland Medical Center, Baltimore

21287

Johns Hopkins University, Baltimore

22031

USO-Virginia Cancer Specialists, PC, Fairfax

27514

University of North Carolina, Chapel Hill

28040

Hospital Universitario Fundación Jiménez Díaz, Madrid

28050

Hospital Madrid Norte Sanchinarro, Madrid

32224

Mayo Clinic in Florida, Jacksonville

33028

Memorial Hospital Pembroke, Pembroke

33076

Institut Bergonié - Centre Régional de Lutte Contre Le Cancer de Bordeaux et Sud Ouest, Bordeaux

34298

Institut du Cancer de Montpellier - Val d'aurelle, Montpellier

37203

Sarah Cannon Research Institute SCRI, Nashville

40705

Taichung Veterans General Hospital, Taichung

44195

Cleveland Clinic Foundation, Cleveland

48109

University of Michigan, Ann Arbor

49546

START Midwest, Grand Rapids

50931

Universitätsklinikum Köln, Cologne

53792

University of Wisconsin-Madison Hospital and Health Clinic, Madison

60637

University of Chicago Medicine-Comprehensive Cancer Center, Chicago

63110

Washington University Medical School, St Louis

69008

Centre Leon Berard, Lyon

70121

Ochsner Clinic Foundation, New Orleans

75015

Hôpital Européen Georges Pompidou, Paris

77030

University of Texas MD Anderson Cancer Center, Houston

80218

Sarah Cannon Research Institute at HealthOne, Denver

84112

Huntsman Cancer Institute, Salt Lake City

85259

Mayo Clinic of Scottsdale, Scottsdale

89169

Comprehensive Cancer Centers of Nevada, Las Vegas

90095

UCLA Medical Center, Los Angeles

92103

University of California - San Diego, San Diego

92663

Hoag Memorial Hospital Presbyterian, Newport Beach

92868

Irvine Medical Center, Orange

94158

UCSF Medical Center at Mission Bay, San Francisco

94596

Kaiser Permanente Medical Center, Walnut Creek

94805

Gustave Roussy, Villejuif

97080

Universitätsklinikum Würzburg A. ö. R., Würzburg

97201

Oregon Health and Science University, Portland

169610

National Cancer Centre Singapore, Singapore

999077

Prince of Wales Hospital, Hong Kong

5262100

Sheba Medical Center, Ramat Gan

8410101

Soroka Medical Center - Pediatric Outpatient Clinic, Beersheba

9103102

Shaare Zedek Medical Center, Jerusalem

9112001

Hadassah Medical Center, Jerusalem

91010-0269

City of Hope National Medical Center, Duarte

94611-5400

Kaiser Permanente, Oakland

06520

Yale Cancer Center, New Haven

30329-5102

Emory University, Atlanta

02114

Massachusetts General Hospital, Boston

02215

Dana-Farber Cancer Institute, Boston

55905-0002

Mayo Clinic, Rochester

43210-1257

Ohio State University Hospital, Columbus

37232-6303

Vanderbilt University Medical Center, Nashville

75390-9063

University of Texas Southwestern Medical Center at Dallas, Dallas

V5Z 4E6

BC Cancer Vancouver, Vancouver

466-8560

Nagoya University Hospital, Nagoya

277-8577

National Cancer Center Hospital East, Kashiwa

060-8648

Hokkaido University Hospital, Sapporo

673-8558

Hyogo Cancer Center, Akashi

920-8641

Kanazawa University Hospital, Kanazawa

589 8511

Kindai University Hospital, Osaka Sayama-shi

411-8777

Tominaga Hospital, Nagaizumi-cho,Sunto-gun

104-0045

National Cancer Center Hospital, Chuo-ku

135-8550

Japanese Foundation for Cancer Research, Koto

683-8504

Tottori University Hospital, Yonago

811-1395

National Hospital Organization Kyushu Cancer Center, Fukuoka

700-8558

Okayama University Hospital, Okayama

534-0021

Osaka City General Hospital, Osaka

03722

Severance Hospital, Yonsei University Health System, Seoul

05505

Asan Medical Center, Seoul

06351

Samsung Medical Center, Seoul

SW3 6JJ

Royal Marsden Hospital, London

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Loxo Oncology, Inc.

INDUSTRY

lead

Eli Lilly and Company

INDUSTRY