NCT03154996 - Chronic Convection Enhanced Delivery of Topotecan | Biotech Hunter

Enrollment

Participants

Timeline

Start Date

January 18, 2018

Primary Completion Date

August 20, 2021

Study Completion Date

August 20, 2021

Conditions

Gliomas

Interventions

DRUG

Topotecan

"Topotecan is a chemotherapeutic agent that is a topoisomerase inhibitor. TPT is administered through an externalized catheter and external microinfusion pump.~Dose: 146 micrometers (uM)"

DRUG

Gadolinium

Gadolinium is a widely available MRI contrast agent that is used routinely in clinical practice via IV administration, especially for imaging of intracranial tumors.

DEVICE

Synchromed II infusion pumps

Implanted subcutaneously to facilitate chronic infusion.

Trial Locations (1)

10032

Columbia University Irving Medical Center, New York

All Listed Sponsors

collaborator

National Cancer Institute (NCI)

NIH

lead

Jeffrey N. Bruce

OTHER