DCb (Docetaxel/Carboplatin) Versus EC-D (Epirubicin/Cyclophosphamide Followed by Docetaxe) as Neoadjuvant Chemotherapy for Triple-Negative Breast Cancer

PHASE2CompletedINTERVENTIONAL
Enrollment

93

Participants

Timeline

Start Date

September 1, 2016

Primary Completion Date

December 31, 2019

Study Completion Date

December 31, 2019

Conditions
Triple-Negative Breast Cancer
Interventions
DRUG

DCb (docetaxel/carboplatin) versus EC followed by D (epirubicin/cyclophosphamide followed by docetaxe)

All eligible patients were randomly assigned at a 1:1 ratio to the experimental arm (docetaxel (75 mg/m2 administered intravenously every 3 weeks) plus carboplatin (AUC 6 mg/mL per min, intravenously every 3 weeks) for six cycles) or the standard treatment arm (epirubicin (90 mg/m2) plus cyclophosphamide (600 mg/m2), both administered intravenously every 3 weeks for four cycles, followed by docetaxel (100 mg/m2) administered intravenously every 3 weeks for four cycles).

Trial Locations (1)

510080

Guangdong General Hospital, Guangzhou

All Listed Sponsors
collaborator

Shantou Central Hospital

OTHER

collaborator

First Affiliated Hospital, Sun Yat-Sen University

OTHER

collaborator

Henan Cancer Hospital

OTHER_GOV

collaborator

Dongguan People's Hospital

OTHER_GOV

collaborator

Baotou Cancer Hospital

OTHER

lead

Guangdong Provincial People's Hospital

OTHER

NCT03154749 - DCb (Docetaxel/Carboplatin) Versus EC-D (Epirubicin/Cyclophosphamide Followed by Docetaxe) as Neoadjuvant Chemotherapy for Triple-Negative Breast Cancer | Biotech Hunter | Biotech Hunter