NCT03150576 - Platinum and Polyadenosine 5'Diphosphoribose Polymerisation Inhibitor for Neoadjuvant Treatment of Triple Negative Breast Cancer and/or Germline BRCA Positive Breast Cancer | Biotech Hunter

Enrollment

780

Participants

Timeline

Start Date

May 31, 2016

Primary Completion Date

June 30, 2024

Study Completion Date

June 30, 2034

Conditions

Breast Cancer

Interventions

DRUG

Olaparib

Patients will self-administer Olaparib by mouth. Olaparib tablets should be taken twice daily at the same time each day approximately 12 hours apart.

DRUG

Paclitaxel and Carboplatin

Paclitaxel I.V. 80mg/m2 in 0.9% sodium chloride 500ml or according to local practice, will be given over 60 minutes on days 1, 8 \& 15, every 3 weeks for 4 cycles. Carboplatin I.V. AUC5 in 5% dextrose 500ml or according to local practice, over 30-60minutes on day 1 every 3 weeks for 4 cycles.

Trial Locations (30)

CB2 0QQ

RECRUITING

Cambridge University Hospitals NHS Foundation Trust & the University of Cambridge, Cambridge

De13 ORB

RECRUITING

Queen's Hospital, Burton-on-Trent

M20 4GJ

RECRUITING

The Christie, Manchester

WF1 4DG

RECRUITING

Pinderfields General Hospital, Wakefield

KA6 6DX

RECRUITING

University Hospital Ayr, Ayr

RG24 9NA

RECRUITING

Basingstoke and North Hampshire Hospital, Basingstoke

Unknown

RECRUITING

Bedford General Hospital, Bedford

BH7 7DW

RECRUITING

Royal Bournemouth Hospital, Bournemouth

BS2 8ED

RECRUITING

Bristol Haematology & Cancer Centre, Bristol

IP33 2QZ

RECRUITING

West Suffolk Hospital, Bury St Edmunds

CF14 2TL

RECRUITING

Velindre Cancer Centre, Cardiff

CO4 5JL

RECRUITING

Colchester General Hospital, Colchester

DY1 2HQ

RECRUITING

Russells Hall Hospital, Dudley

PE29 6NT

RECRUITING

Hinchingbrooke Hospital, Huntingdon

IP4 5PD

RECRUITING

Ipswich Hospital, Ipswich

DY11 6RJ

RECRUITING

Kidderminster General Hospital, Kidderminster

KA2 0BE

RECRUITING

University Hospital Crosshouse, Kilmarnock

NW1 2PG

RECRUITING

University College London Hospital, London

NW3 2QG

RECRUITING

Royal Free Hospital, London

HA6 2RN

RECRUITING

Mount Vernon Cancer Centre, Northwood

NG5 1PB

RECRUITING

Nottingham City Hospital, Nottingham

OX3 7LE

RECRUITING

Churchill Hospital, Oxford

PE3 9GZ

RECRUITING

Peterborough City Hospital, Peterborough

BH15 2JB

RECRUITING

Poole Hospital, Poole

B98 7

RECRUITING

The Alexandra Hopsital, Redditch

RM7 OAG

RECRUITING

Queen's Hospital, Romford

SO16 6YD

RECRUITING

Southampton General Hospital, Southampton

SA2 8QA

RECRUITING

Singleton Hospital, Swansea

SO22 5DG

RECRUITING

Royal Hampshire County Hospital, Winchester

WR5 1DD

RECRUITING

Worcestershire Royal Hospital, Worcester