Early Versus Late Initiation of Direct Oral Anticoagulants in Post-ischaemic Stroke Patients With Atrial fibrillatioN (ELAN): an International, Multicentre, Randomised-controlled, Two-arm, Assessor-blinded Trial

NACompletedINTERVENTIONAL
Enrollment

2,013

Participants

Timeline

Start Date

November 6, 2017

Primary Completion Date

December 21, 2022

Study Completion Date

May 24, 2023

Conditions
Ischaemic Stroke
Interventions
DRUG

Early treatment with Rivaroxaban (Xarelto®), Dabigatran (Pradaxa®), Apixaban (Eliquis®) or Edoxaban (Lixiana®)

Early treatment will be started within 48 hours after symptom onset (minor and moderate ischaemic stroke) or at day 6 + 1 day after symptom onset (major ischaemic stroke)

DRUG

Late treatment with Rivaroxaban (Xarelto®), Dabigatran (Pradaxa®), Apixaban (Eliquis®) or Edoxaban (Lixiana®)

Patients in the control arm will receive late treatment as per current recommendations (i.e. minor ischaemic stroke after day 3 + 1 day, moderate ischaemic stroke after day 6 + 1 day and major ischaemic stroke after day 12 + 2 day).

Trial Locations (98)

1011

Dept. of Neurology, Universitätsspital Lausanne, Lausanne

1180

Cliniques de l'Europe - Site Ste-Elisabeth, Uccle

1200

Cliniques Universitaires Saint-Luc, Brussels

1205

Dept. of Neurology, Universitätsspital Genf, Geneva

1260

Dept. of Neurology, Hôpital de Zone de Nyon, Nyon

1708

Dept. of Neurology, Kantonsspital Fribourg, Fribourg

1951

Dept. of Neurology, Kantonsspital Sion, Sion

2000

Hôpital neuchâtelois, Neuchâtel

2650

Antwerp University Hospital, Edegem

3000

UZ Leuven, Leuven

3004

Vestre Viken Health Trust - Drammen Hospital, Drammen

3010

Dept. of Neurology, Bern University Hospital, Bern

3100

Universitätsklinikum St. Pölten, Sankt Pölten

3430

Universitätsklinikum Tulln, Tulln

4000

CHC - Saint Joseph, Liège

4020

Kepler Universitätsklinikum, Klinik für Neurologie 1, Linz

Kepler Universitätsklinikum, Klinik für Neurologie 2, Linz

4031

Dept. of Neurology, Universitätsspital Basel, Basel

5001

Dept. of Neurology, Kantonsspital Aarau, Aarau

5404

Kantonsspital Baden, Baden

6000

Dept. of Neurology, Kantonsspital Luzern, Lucerne

6900

Ospedale Regionale di Lugano (EOC), Lugano

7000

Dept. of Neurology, Kantonsspital Chur, Chur

8032

Klinik Hirslanden Zürich, Zurich

8036

Medizinische Universität Graz, Graz

8091

Dept. of Neurology, Universitätsspital Zürich, Zurich

8400

Kantonsspital Winterthur, Winterthur

8500

AZ Groeninge, Kortrijk

8596

Kantonsspital Münsterlingen, Münsterlingen

9000

Dept. of Neurology, Kantonsspital St.Gallen, Sankt Gallen

9300

Onze-Lieve-Vrouw Ziekenhuis VZW, Aalst

23562

Universitätsklinikum Schleswig-Holstein, Lübeck

41110

Dept. of Medicine, University of Thessaly, Larissa

44791

St. Josef-Hospital Bochum, Bochum

50937

Klinik und Poliklinik für Neurologie Köln, Cologne

60323

Universitätsklinikum Frankfurt, Frankfurt

68167

Mannheim University Hospital, Mannheim

69120

Neurologische Universitätsklinik Heidelberg, Heidelberg

81377

Klinikum der Universität München, München

91054

Universitätsklinikum Erlangen, Erlangen

110029

All India Institute Of Medical Sciences, New Delhi

141008

Christian Medical College & Hospital, Ludhiana

522001

Lalitha Super Speciality Hospitals, Kothapeta

560099

Narayana Hrudayalaya Bangalore, Bengaluru

682041

Amrita Institute of Medical Sciences, Kochi

695011

Government Medical College Thiruvananthapuram, Thiruvananthapuram

Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum

Unknown

Krankenhaus der Barmherzigen Brüder Eisenstadt, Eisenstadt

Medizinische Universität Wien, Vienna

University Hospital Gent, Ghent

Siun sote - North Karelia social and health services, Joensuu

Vivantes Klinikum Neukölln, Berlin

Universitätsklinikum Hamburg-Eppendorf, Hamburg

Universitäsklinikum Tübingen, Tübingen

Cork University Hospital, Cork

Mater Misericordiae University Hospital, Dublin

St. James's Hospital, Dublin

St. Vincent's University Hospital, Dublin

Tallaght University Hospital, Dublin

University Hospital Waterford, Waterford

Hadassah Medical Center, Jerusalem

Shaare Zedek Medical Center, Jerusalem

Sheba Medical Centre, Ramat Gan

Ospedale Santa Maria della Misericordia, Perugia

Umberto Policlinico di Roma, Rome

St. Marianna Medical University Hospital, Kawasaki

Jichi Medical University, Tochigi

Ålesund sjukehus, Ålesund

Akershus University Hospital, Lørenskog

Coimbra University Hospital, Coimbra

Hospital de Egas Moniz, Lisbon

Fakultná Nemocnica Trnava, Trnava

University Hospital Monklands, Airdrie

Royal United Hospitals Bath, Bath

Countess of Chester Hospital, Chester

Glasgow Royal Infirmary, Glasgow

Queen Elizabeth University Hospital, Glasgow

The James Cook University Hospital, Middlesbrough

Weston General Hospital, Weston-super-Mare

00290

Helsinki University Hospital, Helsinki

04103

Universitätsklinikum Leipzig, Leipzig

573-1010

Kansai Medical University, Hirakata

860-8555

Kumamoto University, Kumamoto

564-8565

National Cerebral and Cardiovascular Center, Osaka

105-0003

The Jikei University Hospital, Tokyo

0450

Oslo University Hospital, Ullevål, Oslo

1649-028

Hospital de Santa Maria, Lisbon

040 11

Košice Medical University, Košice

SW17 0QT

St George's University Hospitals NHS Foundation Trust, Tooting

BS10 5NB

Southmead Hospital Bristol, Bristol

DD2 1SG

Ninewells Hospital, Dundee

DH1 5TW

University Hospital of North Durham, Durham

CH49 5PE

Wirral University Teaching Hospital, Metropolitan Borough of Wirral

SA6 6NL

Morriston Hospital, Morriston

PH1 1NX

Perth Royal Infirmary, Perth

LL18 5UJ

Glan Clwyd Hospital, Rhyl

TS198PE

University Hospital of North Tees, Stockton-on-Tees

ST4 6QG

Royal Stoke University Hospital, Stoke-on-Trent

All Listed Sponsors
lead

Insel Gruppe AG, University Hospital Bern

OTHER

NCT03148457 - Early Versus Late Initiation of Direct Oral Anticoagulants in Post-ischaemic Stroke Patients With Atrial fibrillatioN (ELAN): an International, Multicentre, Randomised-controlled, Two-arm, Assessor-blinded Trial | Biotech Hunter | Biotech Hunter