Mupirocin-Iodophor ICU Decolonization Swap Out Trial

PHASE4CompletedINTERVENTIONAL
Enrollment

353,323

Participants

Timeline

Start Date

May 1, 2017

Primary Completion Date

November 6, 2023

Study Completion Date

November 6, 2023

Conditions
Staphylococcus Aureus
Interventions
DRUG

Arm 1. Routine Care (Mupirocin/CHG)

The intervention / decolonization regimen will consist of 5 days of topical intranasal mupirocin ointment (bilateral nares, twice daily) on ICU admission, in the context of continued daily baths with 2% chlorhexidine cloths.

DRUG

Arm 2. Iodophor/CHG Decolonization

The intervention / decolonization regimen will consist of 5 days of topical intranasal iodophor (10% povidone-iodine nasal swabs) (bilateral nares, twice daily) on ICU admission, in the context of continued daily baths with 2% chlorhexidine cloths.

Trial Locations (137)

20190

Reston Hospital, Reston

22408

Spotsylvania Regional Medical Center, Fredericksburg

23220

Henrico Doctors' Hospital - Retreat Campus, Richmond

23225

CJW Medical Center (Chippenham Campus), Richmond

CJW Medical Center (Johnston Willis Campus), Richmond

23229

Henrico Doctors' Hospital - Forest Campus, Richmond

23294

Henrico Doctors' Hospital - Parham Campus, Richmond

23860

John Randolph Medical Center, Hopewell

24060

LewisGale Hospital - Montgomery, Blacksburg

24153

LewisGale Medical Center, Salem

24301

LewisGale Hospital - Pulaski, Pulaski

24457

LewisGale Hospital - Alleghany, Low Moor

29406

Trident Regional Medical Center, Charleston

29485

Summerville Medical Center, Summerville

29488

Colleton Medical Center, Walterboro

29572

Grand Strand Regional Medical Center, Myrtle Beach

30078

Eastside Medical Center, Snellville

30120

Cartersville Medical Center, Cartersville

30165

Redmond Regional Medical Center, Rome

30909

Doctor's Hospital Augusta, Augusta

31021

Fairview Park, Dublin

31217

Coliseum Medical Centers - Main, Macon

Coliseum Medical Centers - Northside, Macon

32055

Lake City Medical Center, Lake City

32073

Orange Park Medical Center, Orange Park

32216

Memorial Hospital Jacksonville, Jacksonville

32308

Capital Regional Medical Center, Tallahassee

32405

Gulf Coast Medical Center, Panama City

32514

West Florida Hospital, Pensacola

32547

Fort Walton Medical Center, Fort Walton Beach

32578

Twin Cities Hospital, Niceville

32605

North Florida Regional Medical Center, Gainesville

32771

Central Florida Regional Hospital, Sanford

33063

Northwest Medical Center, Margate

33133

Mercy Hospital, Miami

33175

Kendall Regional Medical Center, Miami

33180

Aventura Hospital, Aventura

33317

Plantation General Hospital, Plantation

33321

University Hospital & Medical Center, Tamarac

33324

Westside Regional Medical Center, Plantation

33407

JFK Medical Center - North Campus, West Palm Beach

33462

JFK Medical Center, Atlantis

33470

Palms West Hospital, Loxahatchee Groves

33511

Brandon Regional, Brandon

33573

South Bay Hospital, Sun City Center

33709

Northside Hospital, St. Petersburg

33710

St. Petersburg General Hospital, St. Petersburg

33770

Largo Medical Center, Largo

33952

Fawcett Memorial Hospital, Port Charlotte

34209

Blake Medical Center, Bradenton

34223

Englewood Community Hospital, Englewood

34233

Doctor's Hospital Sarasota, Sarasota

34471

Ocala Regional Medical Center, Ocala

34474

West Marion Community Hospital, Ocala

34613

Oak Hill Hospital, Brooksville

34655

Medical Center of Trinity, Trinity

34667

Regional Medical Center Bayonet Point, Hudson

34741

Osceola Regional Medical Center, Kissimmee

34758

Poinciana Medical Center, Kissimmee

34950

Lawnwood Regional Medical Center, Ft. Pierce

34952

St. Lucie Medical Center, Port Saint Lucie

34972

Raulerson Hospital, Okeechobee

37075

Hendersonville Medical Center, Hendersonville

37076

Summit Medical Center, Hermitage

37167

Stonecrest Medical Center, Nashville

37203

Centennial Medical Center, Nashville

37207

Skyline Medical Center, Nashville

37211

Southern Hills Medical Center, Nashville

37404

Parkridge Medical Center, Chattanooga

37412

Parkridge East Hospital, Chattanooga

39503

Garden Park Medical Center, Gulfport

42104

Greenview Regional Hospital, Bowling Green

47802

Terre Haute Regional Hospital, Terre Haute

64012

Belton Regional Medical Center, Belton

64057

Centerpoint Medical Center, Independence

64063

Lee's Summit Medical Center, Lee's Summit

64132

Research Medical Center, Kansas City

66209

Menorah Medical Center, Overland Park

66215

Overland Park Regional Medical Center, Overland Park

67214

Wesley Medical Center, Wichita

67220

Wesley Woodlawn Hospital, Wichita

70112

Tulane University Hospital & Clinic, New Orleans

70433

Lakeview Regional Medical Center, Covington

71301

Rapides Regional Medical Center, Alexandria

75039

Las Colinas Medical Center, Irving

75057

Medical Center of Lewisville, Lewisville

75069

Medical Center of McKinney, McKinney

75075

Medical Center of Plano, Plano

75230

Medical City Dallas Hospital, Dallas

76015

Medical Center of Arlington, Arlington

76104

Plaza Medical Center of Fort Worth, Fort Worth

76180

North Hills Hospital, North Richland Hills

76210

Denton Regional Medical Center, Denton

77015

East Houston Regional Medical Center, Houston

77082

West Houston Medical Center, Houston

77304

Conroe Regional Medical Center, Conroe

77339

Kingwood Medical Center, Kingwood

77504

Bayshore Medical Center, Pasadena

77591

Mainland Medical Center, Texas City

77598

Clearlake Regional Medical Center, Webster

78212

Metropolitan Methodist Hospital, San Antonio

78229

Methodist Hospital, San Antonio

Methodist Specialty & Transplant Hospital, San Antonio

Methodist Stone Oak Hospital, San Antonio

Methodist Texsan Hospital, San Antonio

Northeast Methodist Hospital, San Antonio

78411

Corpus Christi Medical Center - Doctor's, Corpus Christi

78412

Corpus Christi Medical Center - The Heart Hospital, Corpus Christi

78503

Rio Grande Regional Hospital, McAllen

78526

Valley Regional Medical Center, Brownsville

78681

Round Rock Hospital, Round Rock

78704

South Austin Hospital, Austin

78758

North Austin Medical Center, Austin

79902

Las Palmas Medical Center, El Paso

79925

Del Sol Medical Center, El Paso

80012

The Medical Center of Aurora, Aurora

80113

Swedish Medical Center, Denver

80124

Sky Ridge Medical Center, Denver

80218

Presbyterian St. Luke's Medical Center, Denver

80220

Rose Medical Center, Denver

80229

North Suburban Medical Center - JV, Thornton

83404

Eastern Idaho Regional, Idaho Falls

83605

West Valley Medical Center, Caldwell

84010

Lakeview Hospital, Bountiful

84057

Timpanogos Regional Medical Center, Orem

84405

Ogden Regional Medical Center, Ogden

84651

Mountain View Hospital - Utah, Payson

89109

Sunrise Hospital & Medical Center, Las Vegas

89128

Mountainview Hospital - Vegas, Las Vegas

89148

Southern Hills Hospital - Vegas, Las Vegas

91307

West Hills Hospital & Medical Center, West Hills

91360

Los Robles Regional Medical Center, Thousand Oaks

92501

Riverside Community Hospital, Riverside

95116

Regional Medical Center of San Jose, San Jose

95124

Good Samaritan Hospital, San Jose

03038

Parkland Medical Center, Derry

03801

Portsmouth Regional Hospital, Portsmouth

Sponsors
All Listed Sponsors
collaborator

Hospital Corporation of America

INDUSTRY

collaborator

University of California, Irvine

OTHER

collaborator

University of Massachusetts, Amherst

OTHER

collaborator

Rush University

OTHER

collaborator

Centers for Disease Control and Prevention

FED

lead

Harvard Pilgrim Health Care

OTHER