72
Participants
Start Date
December 31, 2016
Primary Completion Date
April 18, 2023
Study Completion Date
August 29, 2023
Metoprolol Tartrate
Patients will be randomly assigned to receive up-to-three intravenous doses of 5mg metoprolol tartrate (over 15-minutes) at the end of their surgical procedure, and a scheduled oral dose regimen of 25mg metoprolol approximately every 8-hours postoperatively for up to 3-days (or 72 hrs).
Placebo
Patients will be randomly assigned to receive up-to-three intravenous doses of a placebo-comparator (over 15-minutes) at the end of their surgical procedure, and scheduled oral dose regimen of a placebo-comparator approximately every 8-hours postoperatively for up to 3-days (or 72 hrs).
University of Chicago Medicine, Chicago
Washington University School of Medicine, St Louis
National Heart, Lung, and Blood Institute (NHLBI)
NIH
Washington University School of Medicine
OTHER
University of Chicago
OTHER