Maintenance Chemotherapy With or Without Local Consolidative Therapy in Treating Patients With Stage IV Non-small Cell Lung Cancer

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

218

Participants

Timeline

Start Date

April 7, 2017

Primary Completion Date

December 20, 2023

Study Completion Date

December 31, 2028

Conditions
Recurrent Non-Small Cell Lung CarcinomaStage IV Non-Small Cell Lung Cancer
Interventions
RADIATION

3-Dimensional Conformal Radiation Therapy (3D-CRT)

Undergo 3DCRT

DRUG

Docetaxel

Given IV

DRUG

Gemcitabine

Given IV

RADIATION

Intensity-Modulated Radiation Therapy (IMRT)

Undergo IMRT

DRUG

Pemetrexed Disodium

Given IV

RADIATION

Stereotactic Body Radiation Therapy (SBRT)

Undergo SBRT

DRUG

Erlotinib Hydrochloride

Given PO

DRUG

Pembrolizumab

Given IV

Trial Locations (301)

10019

Mount Sinai West, New York

10029

Mount Sinai Hospital, New York

10065

Memorial Sloan Kettering Cancer Center, New York

10461

Montefiore Medical Center-Einstein Campus, The Bronx

10467

Montefiore Medical Center - Moses Campus, The Bronx

10601

Dickstein Cancer Treatment Center, White Plains

10604

Memorial Sloan Kettering Westchester, Harrison

11211

King Faisal Specialist Hospital and Research Centre, Riyadh

11215

New York-Presbyterian/Brooklyn Methodist Hospital, Brooklyn

11553

Memorial Sloan Kettering Nassau, Uniondale

11725

Memorial Sloan Kettering Commack, Commack

11794

Stony Brook University Medical Center, Stony Brook

13210

State University of New York Upstate Medical University, Syracuse

14642

University of Rochester, Rochester

16544

Saint Vincent Hospital, Erie

17044

Lewistown Hospital, Lewistown

17109

UPMC Pinnacle Cancer Center/Community Osteopathic Campus, Harrisburg

17601

Lancaster General Ann B Barshinger Cancer Institute, Lancaster

17602

Lancaster General Hospital, Lancaster

17822

Geisinger Medical Center, Danville

17837

Geisinger Medical Oncology-Lewisburg, Lewisburg

17901

Geisinger Cancer Services-Pottsville, Pottsville

18512

Northeast Radiation Oncology Center, Dunmore

18711

Geisinger Wyoming Valley/Henry Cancer Center, Wilkes-Barre

18840

Guthrie Medical Group PC-Robert Packer Hospital, Sayre

19010

Bryn Mawr Hospital, Bryn Mawr

19026

Delaware County Memorial Hospital, Drexel Hill

19090

Asplundh Cancer Pavilion, Willow Grove

19096

Lankenau Medical Center, Wynnewood

19107

Thomas Jefferson University Hospital, Philadelphia

19111

Fox Chase Cancer Center, Philadelphia

19114

Jefferson Torresdale Hospital, Philadelphia

19301

Paoli Memorial Hospital, Paoli

19611

Reading Hospital, West Reading

19713

Helen F Graham Cancer Center, Newark

19971

Beebe Health Campus, Rehoboth Beach

21044

Central Maryland Radiation Oncology in Howard County, Columbia

21061

UM Baltimore Washington Medical Center/Tate Cancer Center, Glen Burnie

21201

University of Maryland/Greenebaum Cancer Center, Baltimore

21801

TidalHealth Peninsula Regional, Salisbury

21811

TidalHealth Richard A Henson Cancer Institute, Ocean Pines

23235

VCU Massey Cancer Center at Stony Point, Richmond

23298

Virginia Commonwealth University/Massey Cancer Center, Richmond

26506

West Virginia University Healthcare, Morgantown

27710

Duke University Medical Center, Durham

28025

Atrium Health Cabarrus/LCI-Concord, Concord

28112

Atrium Health Union/LCI-Union, Monroe

28203

Carolinas Medical Center/Levine Cancer Institute, Charlotte

28210

Atrium Health Pineville/LCI-Pineville, Charlotte

28262

Atrium Health University City/LCI-University, Charlotte

28401

Novant Health Cancer Institute Radiation Oncology - Wilmington, Wilmington

Novant Health New Hanover Regional Medical Center, Wilmington

28462

Novant Cancer Institute Radiation Oncology - Supply, Supply

28561

CarolinaEast Medical Center, New Bern

29303

Spartanburg Medical Center, Spartanburg

29316

Prisma Health Cancer Institute - Spartanburg, Boiling Springs

29605

Prisma Health Cancer Institute - Faris, Greenville

29607

Saint Francis Cancer Center, Greenville

29615

Prisma Health Cancer Institute - Eastside, Greenville

29646

Self Regional Healthcare, Greenwood

29650

Prisma Health Cancer Institute - Greer, Greer

29651

Gibbs Cancer Center-Pelham, Greer

29672

Prisma Health Cancer Institute - Seneca, Seneca

29926

The Radiation Oncology Center-Hilton Head/Bluffton, Hilton Head Island

30303

Grady Health System, Atlanta

30308

Emory University Hospital Midtown, Atlanta

30322

Emory University Hospital/Winship Cancer Institute, Atlanta

30342

Emory Saint Joseph's Hospital, Atlanta

30912

Augusta University Medical Center, Augusta

31405

Lewis Cancer and Research Pavilion at Saint Joseph's/Candler, Savannah

32308

Tallahassee Memorial HealthCare, Tallahassee

32610

University of Florida Health Science Center - Gainesville, Gainesville

32806

Orlando Health Cancer Institute, Orlando

33136

University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami

33146

UM Sylvester Comprehensive Cancer Center at Coral Gables, Coral Gables

33176

Miami Cancer Institute, Miami

UM Sylvester Comprehensive Cancer Center at Kendall, Miami

33324

UM Sylvester Comprehensive Cancer Center at Plantation, Plantation

33331

Cleveland Clinic-Weston, Weston

33442

UM Sylvester Comprehensive Cancer Center at Deerfield Beach, Deerfield Beach

33612

Moffitt Cancer Center, Tampa

35233

University of Alabama at Birmingham Cancer Center, Birmingham

38120

Baptist Memorial Hospital and Cancer Center-Memphis, Memphis

40202

Norton Hospital Pavilion and Medical Campus, Louisville

The James Graham Brown Cancer Center at University of Louisville, Louisville

40241

Norton Brownsboro Hospital and Medical Campus, Louisville

40536

University of Kentucky/Markey Cancer Center, Lexington

41017

Saint Elizabeth Healthcare Edgewood, Edgewood

43210

Ohio State University Comprehensive Cancer Center, Columbus

43219

The Mark H Zangmeister Center, Columbus

43560

ProMedica Flower Hospital, Sylvania

43701

Genesis Healthcare System Cancer Care Center, Zanesville

44024

Geauga Hospital, Chardon

44060

UH Seidman Cancer Center at Lake Health Mentor Campus, Mentor

44106

Case Western Reserve University, Cleveland

44111

Cleveland Clinic Cancer Center/Fairview Hospital, Cleveland

44122

UHHS-Chagrin Highlands Medical Center, Beachwood

44124

Hillcrest Hospital Cancer Center, Mayfield Heights

44129

University Hospitals Parma Medical Center, Parma

44130

UH Seidman Cancer Center at Southwest General Hospital, Middleburg Heights

44145

UH Seidman Cancer Center at Saint John Medical Center, Westlake

UHHS-Westlake Medical Center, Westlake

44195

Cleveland Clinic Foundation, Cleveland

44266

University Hospitals Portage Medical Center, Ravenna

44307

Cleveland Clinic Akron General, Akron

44691

Cleveland Clinic Wooster Family Health and Surgery Center, Wooster

44870

North Coast Cancer Care, Sandusky

UH Seidman Cancer Center at Firelands Regional Medical Center, Sandusky

44906

Cleveland Clinic Cancer Center Mansfield, Mansfield

45069

University of Cincinnati Cancer Center-West Chester, West Chester

45219

University of Cincinnati Cancer Center-UC Medical Center, Cincinnati

45601

Adena Regional Medical Center, Chillicothe

46158

Franciscan Health Mooresville, Mooresville

46219

Community Cancer Center East, Indianapolis

46227

Community Cancer Center South, Indianapolis

46237

Franciscan Health Indianapolis, Indianapolis

46256

Community Cancer Center North, Indianapolis

46526

Goshen Center for Cancer Care, Goshen

46805

Parkview Hospital Randallia, Fort Wayne

46845

Parkview Regional Medical Center, Fort Wayne

48038

Henry Ford Macomb Hospital-Clinton Township, Clinton Township

48043

McLaren Cancer Institute-Macomb, Mount Clemens

48060

McLaren-Port Huron, Port Huron

48073

Corewell Health William Beaumont University Hospital, Royal Oak

48085

Corewell Health Beaumont Troy Hospital, Troy

48093

Henry Ford Health Warren Hospital, Warren

48154

Trinity Health Saint Mary Mercy Livonia Hospital, Livonia

48201

Wayne State University/Karmanos Cancer Institute, Detroit

48202

Henry Ford Hospital, Detroit

48236

Henry Ford Health Saint John Hospital, Detroit

48334

Weisberg Cancer Treatment Center, Farmington Hills

48341

Michigan Healthcare Professionals Pontiac, Pontiac

48346

McLaren Cancer Institute-Clarkston, Clarkston

48446

McLaren Cancer Institute-Lapeer Region, Lapeer

48532

McLaren Cancer Institute-Flint, Flint

Singh and Arora Hematology Oncology PC, Flint

48601

MyMichigan Medical Center Saginaw, Saginaw

48706

McLaren Cancer Institute-Bay City, Bay City

48910

Karmanos Cancer Institute at McLaren Greater Lansing, Lansing

48912

Mid-Michigan Physicians-Lansing, Lansing

University of Michigan Health - Sparrow Lansing, Lansing

49007

West Michigan Cancer Center, Kalamazoo

49201

Allegiance Health, Jackson

49519

University of Michigan Health - West, Wyoming

49770

McLaren Cancer Institute-Northern Michigan, Petoskey

50309

Iowa Methodist Medical Center, Des Moines

50314

Mercy Medical Center - Des Moines, Des Moines

50325

Mercy Cancer Center-West Lakes, Clive

52621

Chaim Sheba Medical Center, Tel Litwinsky

53022

Aurora Health Care Germantown Health Center, Germantown

53024

Aurora Cancer Care-Grafton, Grafton

53051

Froedtert Menomonee Falls Hospital, Menomonee Falls

53066

Aurora Medical Center in Summit, Summit

53081

Vince Lombardi Cancer Clinic-Sheboygan, Sheboygan

53095

Froedtert West Bend Hospital/Kraemer Cancer Center, West Bend

53105

Aurora Cancer Care-Southern Lakes VLCC, Burlington

53142

Aurora Cancer Care-Kenosha South, Kenosha

53209

Aurora Cancer Care-Milwaukee, Milwaukee

53215

Aurora Saint Luke's Medical Center, Milwaukee

53226

Medical College of Wisconsin, Milwaukee

Aurora Cancer Care-Milwaukee West, Wauwatosa

53227

Aurora West Allis Medical Center, West Allis

53233

Aurora Sinai Medical Center, Milwaukee

53406

Aurora Cancer Care-Racine, Racine

54143

Aurora Bay Area Medical Group-Marinette, Marinette

54241

Vince Lombardi Cancer Clinic-Two Rivers, Two Rivers

54301

Saint Vincent Hospital Cancer Center Green Bay, Green Bay

54303

Saint Vincent Hospital Cancer Center at Saint Mary's, Green Bay

54311

Aurora BayCare Medical Center, Green Bay

54401

Aspirus Regional Cancer Center, Wausau

54409

Langlade Hospital and Cancer Center, Antigo

54449

Marshfield Medical Center-Marshfield, Marshfield

54476

Marshfield Medical Center - Weston, Weston

54482

Marshfield Medical Center-River Region at Stevens Point, Stevens Point

54494

Aspirus Cancer Care - Wisconsin Rapids, Wisconsin Rapids

54548

Marshfield Medical Center - Minocqua, Minocqua

54601

Gundersen Lutheran Medical Center, La Crosse

54701

Marshfield Medical Center-EC Cancer Center, Eau Claire

54904

Ascension Mercy Hospital, Oshkosh

Vince Lombardi Cancer Clinic - Oshkosh, Oshkosh

54915

Ascension Saint Elizabeth Hospital, Appleton

54937

Aurora Health Center-Fond du Lac, Fond du Lac

55101

Regions Hospital, Saint Paul

55415

Hennepin County Medical Center, Minneapolis

55805

Saint Luke's Hospital of Duluth, Duluth

56303

Coborn Cancer Center at Saint Cloud Hospital, Saint Cloud

56601

Sanford Joe Lueken Cancer Center, Bemidji

58122

Sanford Roger Maris Cancer Center, Fargo

58201

Altru Cancer Center, Grand Forks

58501

Sanford Bismarck Medical Center, Bismarck

59405

Benefis Sletten Cancer Institute, Great Falls

59701

Saint James Community Hospital and Cancer Treatment Center, Butte

59715

Bozeman Health Deaconess Hospital, Bozeman

59901

Logan Health Medical Center, Kalispell

60048

Condell Memorial Hospital, Libertyville

60068

Advocate Lutheran General Hospital, Park Ridge

60141

Edward Hines Jr VA Hospital, Hines

60153

Loyola University Medical Center, Maywood

60611

Northwestern University, Chicago

60612

Rush University Medical Center, Chicago

University of Illinois, Chicago

61114

UW Health Carbone Cancer Center Rockford, Rockford

61401

Western Illinois Cancer Treatment Center, Galesburg

61636

Methodist Medical Center of Illinois, Peoria

61637

OSF Saint Francis Medical Center, Peoria

61801

Carle Cancer Center, Urbana

62226

Southwest Illinois Health Services LLP, Swansea

62401

Crossroads Cancer Center, Effingham

62526

Decatur Memorial Hospital, Decatur

62781

Springfield Memorial Hospital, Springfield

63110

Washington University School of Medicine, St Louis

63131

Missouri Baptist Medical Center, St Louis

63141

Siteman Cancer Center at West County Hospital, Creve Coeur

Mercy Hospital Saint Louis, St Louis

63703

Saint Francis Medical Center, Cape Girardeau

64128

Kansas City Veterans Affairs Medical Center, Kansas City

65401

Delbert Day Cancer Institute at PCRMC, Rolla

65804

Mercy Hospital Springfield, Springfield

66044

Lawrence Memorial Hospital, Lawrence

66160

University of Kansas Cancer Center, Kansas City

66210

University of Kansas Cancer Center-Overland Park, Overland Park

67214

Ascension Via Christi Hospitals Wichita, Wichita

68114

Nebraska Methodist Hospital, Omaha

68124

Alegent Health Bergan Mercy Medical Center, Omaha

70805

LSU Health Baton Rouge-North Clinic, Baton Rouge

70808

Our Lady of the Lake Physician Group, Baton Rouge

70809

Louisiana Hematology Oncology Associates LLC, Baton Rouge

Mary Bird Perkins Cancer Center, Baton Rouge

72205

University of Arkansas for Medical Sciences, Little Rock

73104

University of Oklahoma Health Sciences Center, Oklahoma City

73120

Mercy Hospital Oklahoma City, Oklahoma City

75390

UT Southwestern/Simmons Cancer Center-Dallas, Dallas

76104

UT Southwestern/Simmons Cancer Center-Fort Worth, Fort Worth

77030

M D Anderson Cancer Center, Houston

78229

University of Texas Health Science Center at San Antonio, San Antonio

79410

Covenant Medical Center-Lakeside, Lubbock

80210

Porter Adventist Hospital, Denver

80524

Poudre Valley Hospital, Fort Collins

80907

Penrose-Saint Francis Healthcare, Colorado Springs

80909

UCHealth Memorial Hospital Central, Colorado Springs

83687

Saint Alphonsus Cancer Care Center-Nampa, Nampa

84112

Huntsman Cancer Institute/University of Utah, Salt Lake City

84148

George E Wahlen Department of Veterans Affairs Medical Center, Salt Lake City

85054

Mayo Clinic Hospital in Arizona, Phoenix

85258

Arizona Center for Cancer Care - Scottsdale, Scottsdale

85259

Mayo Clinic in Arizona, Scottsdale

85297

Arizona Center for Cancer Care - Gilbert, Gilbert

85381

Arizona Center for Cancer Care-Peoria, Peoria

85704

University of Arizona Cancer Center-Orange Grove Campus, Tucson

85719

Banner University Medical Center - Tucson, Tucson

University of Arizona Cancer Center-North Campus, Tucson

87102

Lovelace Medical Center-Saint Joseph Square, Albuquerque

87106

University of New Mexico Cancer Center, Albuquerque

87109

Lovelace Radiation Oncology, Albuquerque

87505

Christus Saint Vincent Regional Cancer Center, Santa Fe

89502

Renown Regional Medical Center, Reno

90033

Los Angeles General Medical Center, Los Angeles

USC / Norris Comprehensive Cancer Center, Los Angeles

91010

City of Hope Comprehensive Cancer Center, Duarte

91030

City of Hope South Pasadena, South Pasadena

92093

UC San Diego Moores Cancer Center, La Jolla

92868

Saint Joseph Hospital - Orange, Orange

93901

Salinas Valley Memorial, Salinas

94080

Kaiser Permanente Cancer Treatment Center, South San Francisco

94574

Saint Helena Hospital, St. Helena

94704

Alta Bates Summit Medical Center-Herrick Campus, Berkeley

95355

Memorial Medical Center, Modesto

95678

The Permanente Medical Group-Roseville Radiation Oncology, Roseville

95816

Sutter Medical Center Sacramento, Sacramento

95817

University of California Davis Comprehensive Cancer Center, Sacramento

96161

Gene Upshaw Memorial Tahoe Forest Cancer Center, Truckee

96813

Queen's Medical Center, Honolulu

96817

The Cancer Center of Hawaii-Liliha, Honolulu

97030

Legacy Mount Hood Medical Center, Gresham

97210

Legacy Good Samaritan Hospital and Medical Center, Portland

97213

Providence Portland Medical Center, Portland

97225

Providence Saint Vincent Medical Center, Portland

97330

Good Samaritan Hospital, Corvallis

98686

Legacy Salmon Creek Hospital, Vancouver

06520

Yale University, New Haven

32224-9980

Mayo Clinic in Florida, Jacksonville

02114

Massachusetts General Hospital Cancer Center, Boston

02115

Brigham and Women's Hospital, Boston

02118

Boston Medical Center, Boston

01805

Lahey Hospital and Medical Center, Burlington

03820

Wentworth-Douglass Hospital, Dover

03756

Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon

07920

Memorial Sloan Kettering Basking Ridge, Basking Ridge

07748

Memorial Sloan Kettering Monmouth, Middletown

07645

Memorial Sloan Kettering Bergen, Montvale

08057

Virtua Samson Cancer Center, Moorestown

08060

Virtua Memorial, Mount Holly

08755

Community Medical Center, Toms River

08043

Virtua Voorhees, Voorhees Township

17033-0850

Penn State Milton S Hershey Medical Center, Hershey

57117-5134

Sanford USD Medical Center - Sioux Falls, Sioux Falls

77555-0565

University of Texas Medical Branch, Galveston

05819

Dartmouth Cancer Center - North, Saint Johnsbury

T6G 1Z2

Cross Cancer Institute, Edmonton

N6A 4L6

London Regional Cancer Program, London

K1H 8L6

Ottawa Hospital and Cancer Center-General Campus, Ottawa

Sponsors

Lead Sponsor

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

NRG Oncology

OTHER

NCT03137771 - Maintenance Chemotherapy With or Without Local Consolidative Therapy in Treating Patients With Stage IV Non-small Cell Lung Cancer | Biotech Hunter | Biotech Hunter