NCT03136484View on ClinicalTrials.gov

Efficacy and Safety of Semaglutide Versus Canagliflozin as add-on to Metformin in Subjects With Type 2 Diabetes

PHASE3CompletedINTERVENTIONAL
Enrollment

788

Participants

Timeline

Start Date

March 15, 2017

Primary Completion Date

October 16, 2018

Study Completion Date

November 16, 2018

Conditions
DiabetesDiabetes Mellitus, Type 2
Interventions
DRUG

Semaglutide

Following a dose escalation phase of 8 weeks, semaglutide 1.0 mg once-weekly(administered subcutaneously, s.c., under the skin) and canagliflozin placebo once-daily (administered orally, as a tablet). Subjects will continue on their pre-trial daily dose of metformin.

DRUG

Canagliflozin

Following a dose escalation phase of 8 weeks, canagliflozin 300 mg once-daily (administered orally, as a tablet) and semaglutide placebo (administered subcutaneously, s.c., under the skin). Subjects will continue on their pre-trial daily dose of metformin.

DRUG

Placebo (canagliflozin)

Following a dose escalation phase of 8 weeks, semaglutide 1.0 mg once-weekly(administered subcutaneously, s.c., under the skin) and canagliflozin placebo once-daily (administered orally, as a tablet). Subjects will continue on their pre-trial daily dose of metformin.

DRUG

Placebo (semaglutide)

Following a dose escalation phase of 8 weeks, canagliflozin 300 mg once-daily (administered orally, as a tablet) and semaglutide placebo (administered subcutaneously, s.c., under the skin). Subjects will continue on their pre-trial daily dose of metformin.

Trial Locations (119)

4400

Novo Nordisk Investigational Site, Salta

9611

Novo Nordisk Investigational Site, Lebanon - Beirut

9616

Novo Nordisk Investigational Site, Zghartā

10450

Novo Nordisk Investigational Site, George Town

11229

Novo Nordisk Investigational Site, Brooklyn

12553

Novo Nordisk Investigational Site, New Windsor

20100

Novo Nordisk Investigational Site, Milan

20171

Novo Nordisk Investigational Site, Herndon

20782

Novo Nordisk Investigational Site, Hyattsville

21239

Novo Nordisk Investigational Site, Baltimore

27408

Novo Nordisk Investigational Site, Greensboro

29621

Novo Nordisk Investigational Site, Anderson

30060

Novo Nordisk Investigational Site, Marietta

30450

Novo Nordisk Investigational Site, Ipoh

32003

Novo Nordisk Investigational Site, Fleming Island

33009

Novo Nordisk Investigational Site, Hallandale

33012

Novo Nordisk Investigational Site, Hialeah

33135

Novo Nordisk Investigational Site, Miami

33155

Novo Nordisk Investigational Site, Miami

33174

Novo Nordisk Investigational Site, Miami

33175

Novo Nordisk Investigational Site, Miami

33186

Novo Nordisk Investigational Site, Miami

34609

Novo Nordisk Investigational Site, Spring Hill

40503

Novo Nordisk Investigational Site, Lexington

43537

Novo Nordisk Investigational Site, Maumee

43614

Novo Nordisk Investigational Site, Toledo

43623

Novo Nordisk Investigational Site, Toledo

45212

Novo Nordisk Investigational Site, Cincinnati

48098

Novo Nordisk Investigational Site, Troy

48202

Novo Nordisk Investigational Site, Detroit

48504

Novo Nordisk Investigational Site, Flint

48532

Novo Nordisk Investigational Site, Flint

51501

Novo Nordisk Investigational Site, Council Bluffs

62250

Novo Nordisk Investigational Site, Cuernavaca

64620

Novo Nordisk Investigational Site, Monterrey

70002

Novo Nordisk Investigational Site, Metairie

70300

Novo Nordisk Investigational Site, Seremban

70601

Novo Nordisk Investigational Site, Lake Charles

75230

Novo Nordisk Investigational Site, Dallas

75251

Novo Nordisk Investigational Site, Dallas

75400

Novo Nordisk Investigational Site, Malacca

77058

Novo Nordisk Investigational Site, Houston

77074

Novo Nordisk Investigational Site, Houston

77081

Novo Nordisk Investigational Site, Houston

77372

Novo Nordisk Investigational Site, Splendora

77450

Novo Nordisk Investigational Site, Katy

78230

Novo Nordisk Investigational Site, San Antonio

78300

Novo Nordisk Investigational Site, Alor Gajah

78404

Novo Nordisk Investigational Site, Corpus Christi

78413

Novo Nordisk Investigational Site, Corpus Christi

79106

Novo Nordisk Investigational Site, Amarillo

83646

Novo Nordisk Investigational Site, Meridian

84790

Novo Nordisk Investigational Site, St. George

90000

Novo Nordisk Investigational Site, Sandakan

90057

Novo Nordisk Investigational Site, Los Angeles

91763

Novo Nordisk Investigational Site, Montclair

91942

Novo Nordisk Investigational Site, La Mesa

91978

Novo Nordisk Investigational Site, Spring Valley

92111

Novo Nordisk Investigational Site, San Diego

92780

Novo Nordisk Investigational Site, Tustin

92801

Novo Nordisk Investigational Site, Anaheim

94598

Novo Nordisk Investigational Site, Walnut Creek

98502

Novo Nordisk Investigational Site, Olympia

124001

Novo Nordisk Investigational Site, Rohtak

302006

Novo Nordisk Investigational Site, Jaipur

400008

Novo Nordisk Investigational Site, Mumbai

440008

Novo Nordisk Investigational Site, Nagpur

500034

Novo Nordisk Investigational Site, Hyderabad

560054

Novo Nordisk Investigational Site, Bangalore

600001

Novo Nordisk Investigational Site, Chennai

682041

Novo Nordisk Investigational Site, Kochi

700020

Novo Nordisk Investigational Site, Kolkata

700054

Novo Nordisk Investigational Site, Kolkata

30094-5965

Novo Nordisk Investigational Site, Conyers

48310-3503

Novo Nordisk Investigational Site, Sterling Heights

08611

Novo Nordisk Investigational Site, Trenton

97330-3737

Novo Nordisk Investigational Site, Corvallis

75390-9302

Novo Nordisk Investigational Site, Dallas

98801-2028

Novo Nordisk Investigational Site, Wenatchee

C1250AAN

Novo Nordisk Investigational Site, Buenos Aires

C1093AAS

Novo Nordisk Investigational Site, CABA

C1430CKE

Novo Nordisk Investigational Site, CABA

S2000CUD

Novo Nordisk Investigational Site, Rosario

90035-170

Novo Nordisk Investigational Site, Porto Alegre

22271-100

Novo Nordisk Investigational Site, Rio de Janeiro

V3S 2N6

Novo Nordisk Investigational Site, Surrey

L6T 0G1

Novo Nordisk Investigational Site, Brampton

L7M 4Y1

Novo Nordisk Investigational Site, Burlington

N5W 6A2

Novo Nordisk Investigational Site, London

N7T 4X3

Novo Nordisk Investigational Site, Sarnia

M9V 4B4

Novo Nordisk Investigational Site, Toronto

H9R 3J1

Novo Nordisk Investigational Site, Pointe-Claire

H9R 4S3

Novo Nordisk Investigational Site, Pointe-Claire

600 013

Novo Nordisk Investigational Site, Chennai

DUBLIN 15

Novo Nordisk Investigational Site, Dublin

DUBLIN 4

Novo Nordisk Investigational Site, Dublin

DUBLIN 7

Novo Nordisk Investigational Site, Dublin

H91 YR71

Novo Nordisk Investigational Site, Galway

P51Y8EC

Novo Nordisk Investigational Site, Mallow

Unknown

Novo Nordisk Investigational Site, El Achrafiyé

Novo Nordisk Investigational Site, Hazmiyeh

Novo Nordisk Investigational Site, Mansourieh

02230

Novo Nordisk Investigational Site, Mexico City

575 35

Novo Nordisk Investigational Site, Eksjö

291 85

Novo Nordisk Investigational Site, Kristianstad

221 85

Novo Nordisk Investigational Site, Lund

205 02

Novo Nordisk Investigational Site, Malmo

701 85

Novo Nordisk Investigational Site, Örebro

RG24 9GT

Novo Nordisk Investigational Site, Basingstoke

BA15 1DQ

Novo Nordisk Investigational Site, Bradford-on-Avon

DD1 9SY

Novo Nordisk Investigational Site, Dundee

DN9 2HY

Novo Nordisk Investigational Site, Haxey

NG7 2UH

Novo Nordisk Investigational Site, Nottingham

PL8 8DQ

Novo Nordisk Investigational Site, Plymouth

CB7 5JD

Novo Nordisk Investigational Site, Soham

SO30 3JB

Novo Nordisk Investigational Site, Southampton

SG1 4AB

Novo Nordisk Investigational Site, Stevenage

TQ2 7AA

Novo Nordisk Investigational Site, Torquay

NN8 4RW

Novo Nordisk Investigational Site, Wellingborough

Sponsors

Lead Sponsor

Novo Nordisk A/S
All Listed Sponsors
lead

Novo Nordisk A/S

INDUSTRY

NCT03136484 - Efficacy and Safety of Semaglutide Versus Canagliflozin as add-on to Metformin in Subjects With Type 2 Diabetes | Biotech Hunter | Biotech Hunter