Osimertinib and Bevacizumab Versus Osimertinib Alone as Second-line Treatment in Stage IIIb-IVb NSCLC With Confirmed EGFRm and T790M (BOOSTER)

PHASE2CompletedINTERVENTIONAL
Enrollment

155

Participants

Timeline

Start Date

May 31, 2017

Primary Completion Date

February 22, 2021

Study Completion Date

February 29, 2024

Conditions
Non Small Cell Lung Cancer Metastatic
Interventions
DRUG

Osimertinib

"Osimertinib is administered orally at 80mg once daily. Doses should be taken approximately 24 hours apart at the same time point each day. The appropriate number of osimertinib tablets will be provided to patients to be self-administered at home. AstraZeneca will supply osimertinib as tablets for oral administration.~AstraZeneca will supply osimertinib as tablets for oral administration."

DRUG

Bevacizumab

Bevacizumab is administered at 15mg/kg intravenously on day 1 of every 3-week cycle. Bevacizumab for intravenous administration will be supplied by Roche.

Trial Locations (25)

Unknown

St. James Hospital, Dublin

Mid Western Cancer Centre, Limerick

VU University Medical Centre, Amsterdam

National University Hospital, Singapore

Tan Tock Seng Hospital, Singapore

National Cancer Centre, Goyang

Severance Hospital, Yonsei University Health System, Seoul

Hospital Teresa Herrara, A Coruña

Hospital General Alicante, Alicante

Hospital Sant Pau, Barcelona

ICO Badalona, Barcelona

ICO Hospitalet, Barcelona

OSI Bilbao Basurto, Bilbao

Fund. Jimenez Diaz, Madrid

Hospital de la Princesa, Madrid

Hospital la Paz, Madrid

Hospital Puerta de Hierro, Madrid

Hospital Virgen del Rocio, Seville

Hospital Arnau de Vilanova, Valencia

Hospital General de Valencia, Valencia

Geneva University Hospital (HUG), Geneva

Centre Hospitalier Universitaire Vaudois, Lausanne

Kantonsspital St. Gallen, Sankt Gallen

Kantonsspital Winterthur, Winterthur

UniversitatSpital Zurich, Zurich

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

AstraZeneca

INDUSTRY

collaborator

Hoffmann-La Roche

INDUSTRY

lead

ETOP IBCSG Partners Foundation

NETWORK