The Danish Non-vitamin K Antagonist Oral Anticoagulation Study in Patients With Atrial Fibrillation

PHASE4Active, not recruitingINTERVENTIONAL
Enrollment

11,000

Participants

Timeline

Start Date

April 1, 2023

Primary Completion Date

October 30, 2027

Study Completion Date

October 30, 2027

Conditions
Atrial FibrillationAtrial Flutter
Interventions
DRUG

Dabigatran Etexilate Oral Capsule

After cluster randomization, the cluster will use dabigatran to all their patients with non-valvular atrial fibrillation when possible for six months. Hereafter the cluster will use the other three NOACs for six months one at the time. It is the clusters and not the patient that are randomized.

DRUG

Rivaroxaban Oral Tablet

After cluster randomization, the cluster will use rivaroxaban to all their patients with non-valvular atrial fibrillation when possible for six months. Hereafter the cluster will use the other three NOACs for six months one at the time. It is the clusters and not the patient that are randomized.

DRUG

Edoxaban Oral Tablet

After cluster randomization, the cluster will use edoxaban to all their patients with non-valvular atrial fibrillation when possible for six months. Hereafter the cluster will use the other three NOACs for six months one at the time. It is the clusters and not the patient that are randomized.

DRUG

Apixaban Oral Tablet

After cluster randomization, the cluster will use apixaban to all their patients with non-valvular atrial fibrillation when possible for six months. Hereafter the cluster will use the other three NOACs for six months one at the time. It is the clusters and not the patient that are randomized.

Trial Locations (38)

1264

Hjertelæge Christian Lange, Copenhagen

2000

Bispebjerg and Frederiksberg Hospital - Department of Cardiology, Frederiksberg

Frederiksberg Hjerteklinik, Frederiksberg

2100

Hjerteklinik Østerbro I/S, Copenhagen Ø

Rigshospitalet, Copenhagen Ø

2300

Amager Hospital, Copenhagen S

2400

Bispebjerg Hospital - Department of Neurology, Copenhagen NV

2600

Glostrup Hospital - Department of Emergency Medicine, Glostrup Municipality

Glostrup Hospital - Department of Medicine / Cardiology, Glostrup Municipality

Glostrup Hospital - Department of Neurology, Glostrup Municipality

2630

Klinik Hjertesund, Taastrup

2650

Hvidovre Hospital, Hvidovre

2730

Herlev-Gentofte Hospital - Department of Medicine, Herlev

2750

Hjertelægerne i Ballerup, Ballerup Municipality

2840

Speciallæge Michael Dilou Jacobsen, Holte

2900

Gentofte Hospital, Gentofte Municipality

3400

Hjertelægerne i Hillerød, Hillerød

Nordsjællands Hospital - Hillerød, Hillerød

3600

Nordsjællands Hospital - Frederiksund, Frederikssund

3700

Bornholms Hospital, Rønne

4000

Zealand University Hospital - Department of Neurology, Roskilde

Zealand University Hospital Roskilde - Department of Cardiology, Roskilde

4200

Slagelse Hospital, Slagelse

4300

Holbæk Hospital, Holbæk

4700

Næstved Hospital, Næstved

5000

Odense University Hospital - Department of Cardiology, Odense

Odense University Hospital - Department of Emergency Medicine, Odense

Odense University Hospital - Department of Geriatrics, Odense

Odense University Hospital - Department of Neurology, Odense

5700

Odense University Hospital Svendborg, Svendborg

6700

Esbjerg Hospital, Esbjerg

7100

Vejle Hospital, Vejle

8200

Aarhus University Hospital, Aarhus

9800

Hjørring Hospital, Hjørring

Unknown

Hjerteklinik Nordjylland, Aalborg

Bispebjerg Hospital - Department of Geriatrics, Copenhagen

Hjerteklinikken Amaliegade, Copenhagen

Hjerteklinikken ved Speciallæge Anders Galløe, Copenhagen

All Listed Sponsors
lead

Herlev and Gentofte Hospital

OTHER