HOPE for Human Extended Criteria and Donation After Brain Death Donor (ECD-DBD) Liver Allografts

NACompletedINTERVENTIONAL
Enrollment

46

Participants

Timeline

Start Date

January 17, 2017

Primary Completion Date

September 30, 2020

Study Completion Date

September 30, 2020

Conditions
Hepatocellular InjuryLiver Transplant
Interventions
DEVICE

Hypothermic oxygenated perfusion (HOPE)

HOPE for 1 hour via the portal vein in a recirculating and pressure controlled system (2-3 mm Hg), 0.1 ml/g liver/min, perfusion volume 3-4 L, Belzer (UW) machine perfusion solution, perfusate temperature 10 °C, perfusate oxygenation pO2 of 60-80 kPa

PROCEDURE

Conventional cold storage (CCS)

Conventional static cold storage (CCS) on temperature 4-6 °C from organ procurement

Trial Locations (4)

52074

Department of Surgery and Transplantation, University Hospital RWTH Aachen, Aachen

81377

Department of General, Visceral, and Transplant Surgery, Ludwig-Maximilians-University Munich, Munich

Unknown

Department of Transplantation Surgery, Institute for Clinical and Experimental Medicine, Prague

"Department of Surgery, Campus Charité Mitte , Campus Virchow-Klinikum, Charité-Universitätsmedizin Berlin, Germany"

All Listed Sponsors
lead

University Hospital, Aachen

OTHER

NCT03124641 - HOPE for Human Extended Criteria and Donation After Brain Death Donor (ECD-DBD) Liver Allografts | Biotech Hunter | Biotech Hunter