Efficacy and Safety of Olokizumab in Subjects With Moderately to Severely Active Rheumatoid Arthritis

PHASE3CompletedINTERVENTIONAL
Enrollment

2,106

Participants

Timeline

Start Date

July 4, 2017

Primary Completion Date

September 1, 2021

Study Completion Date

September 1, 2021

Conditions
Rheumatoid Arthritis
Interventions
DRUG

Olokizumab 64 mg SC q4w

160 mg/mL sterile solution for SC injection in a 2 mL clear Type I glass vial with target volume of 0.4 mL or in the pre-filled syringe (PFS).PFS is composed of a 1 mL clear Type I glass barrel vial with target volume of 0.4 mL.

DRUG

Olokizumab 64 mg SC q2w

160 mg/mL sterile solution for SC injection in a 2 mL clear Type I glass vial with target volume of 0.4 mL or in the pre-filled syringe (PFS). PFS is composed of a 1 mL clear Type I glass barrel vial with target volume of 0.4 mL.

DRUG

Concomitant treatment

"Methotrexate 15 to 25 mg/week (or ≥ 10 mg/week if there was documented intolerance to higher doses). (Subject maintained their stable dose and route (oral, SC, or IM) during the core study and for ≥ 12 additional weeks of OLE.)~Folic acid ≥ 5 mg per week or equivalent"

Trial Locations (239)

333

Chang Gung Memorial Hospital, Linkou, Taoyuan District

710

Chi Mei Medical Center, Yung Kang Branch, Tainan City

1033

Clinexpert Kft., Budapest

1036

Obudai Egeszsegugyi Centrum Kft., Budapest

1233

"NMTH Tsar Boris III", Sofia

1336

"MHAT Lyulin, EAD", Sofia

1407

"Medical Center Excelsior, OOD", Sofia

1431

"UMHAT Sv. Ivan Rilski, EAD", Sofia

1784

"MC Synexus - Sofia, EOOD", Sofia

3300

Clinicos Asociados BOCM S.C., Mexico City

3720

Centro de Investigacion Clínica GRAMEL S.C, Mexico City

4000

UMHAT Pulmed OOD, Plovdiv

4001

"UMHAT Kaspela, EOOD", Plovdiv

5000

MDHAT 'Dr. Stefan Cherkezov', AD, Veliko Tarnovo

MAV Korhaz es Rendelointezet, Szolnok

5016

Hospital Privado Centro Medico de Cordoba, Córdoba

5400

CER San Juan Centro Polivalente de Asistencia e Inv. Clinica, San Juan

Medizinski Zentar-1-Sevlievo EOOD, Sevlievo

5800

DCC 'Sv. Pantaleymon' OOD, Pleven

6100

Comite Mexicano Para la Prevencion de Osteoporosis AC, Mexico City

6400

Kiskunhalasi Semmelweis Korhaz, Kiskunhalas

6500

Principal SMO Kft., Baja

6591

The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul

6700

Clinstile, S.A. de C.V., Mexico City

7002

MHAT - Ruse, AD, Rousse

8000

DRC Szekesfehervar, Székesfehérvár

8200

Vital-Medicina Kft., Veszprém

8230

DRC Gyogyszervizsgalo Kozpont Kft., Balatonfüred

9700

MHAT - Shumen, AD, Shumen

10117

Klinische Forschung Berlin-Mitte GmbH, Berlin

11201

NYU Langone ambulatory care, Brooklyn

11312

East Tallinn Central Hospital, Tallinn

16635

Altoona Center for Clinical Research, P.C., Duncansville

19152

Arthritis Group, Philadelphia

19713

Javed Rheumatology Associates, Newark

20095

HRF Hamburger Rheuma Forschungszentrum, Hamburg

20902

The Center for Rheumatology and Bone Research, Wheaton

21740

Klein and Associates, M.D., P.A., Hagerstown

27408

Medication Management, LLC, Greensboro

28401

Carolina Arthritis Associates, Wilmington

28451

Cape Fear Arthritis Care, Leland

29486

Low Country Rheumatology, PA, Summerville

30060

Marietta Rheumatology Associates, PC, Marietta

30501

Arthritis Center of North Georgia, Gainesville

31000

Investigacion y Biomedicina de Chihuahua, S.C., Chihuahua City

32810

Omega Research Consultants, Orlando

33012

Reliable Clinical Research, LLC, Hialeah

33026

Family Clinical Trials, LLC., Pembroke Pines

33126

Pharmax Research Clinic, Miami

33134

Medical Research Center of Miami, Miami

33135

Suncoast Research Group, LLC, Miami

33486

RASF - Clinical Research Center, Boca Raton

33614

AdventHealth Medical Group, PA, Tampa

34292

Lovelace Scientific Resources, Inc., Venice

34684

Arthritis Research of Florida, INC, Palm Harbor

35233

Eulji University Hospital, Daejeon

38801

North MS Medical Clinics, Inc., Tupelo

39120

SMO.MD GmbH, Magdeburg

40878

Studienambulanz Dr. Wassenberg, Ratingen

42101

Graves Gilbert Clinic, Bowling Green

43606

Clinical Research Source, Inc., Toledo

44650

Clinica de Investigacion en Reumatologia y Obesidad S.C., Guadalajara

44690

Centro de Estudios de Investigacion Basica y Clinica SC, Guadalajara

45130

Republican Kaunas Hospital, Public Institution, Kaunas

45242

Cincinnati Rheumatic Disease Study Group, Cincinnati

45417

STAT Research, Inc., Dayton

48439

AA MRC LLC Ahmed Arif Medical Research Center, Grand Blanc

50708

Meditrials OU, Tartu

52064

Rheumapraxis Dr. med. Reiner Kurthen, Aachen

54055

Clinical Research Institute S.C., Mexico City

58701

Trinity Medical Group, Minot

59901

Glacier View Research Institute-Rheumatology, Kalispell

61231

Kerckhoff-Klinik gGmbH, Bad Nauheim

62114

Alytus Regional S. Kudirkos Hospital, Public Institution, Alytus

63241

Jeju National University Hospital, Jeju City

64000

Accelerium S. de R.L. de C.V., Monterrey

64460

Universidad Autonoma de Nuevo Leon, Hospital Universitario Dr. Jose Eleuterio Gonzalez, Monterrey

66160

University of Kansas Hospital, Kansas City

68516

Physician Research Collaboration, Lincoln

70200

Vesalion s.r.o., Ostrava

71203

The Arthritis & Diabetes Clinic, Inc., Monroe

71913

CHI St. Vincent Hot Springs, Hot Springs

73103

Health Research of Oklahoma, PLLC, Oklahoma City

73112

Lynn Health Science Institute, Oklahoma City

76001

Clinica de Artritis Temprana S.A.S, Santiago de Cali

76034

Precision Comprehensive Clinical Research Solutions, Colleyville

76231

Siauliai Republican Hospital, Public Institution, Šiauliai

77004

Therapeutic Concepts Rheumatology,LLC, Houston

77065

Rheumatology Clinic of Houston, P.A., Houston

77074

Houston Institute For Clinical Research, Houston

77089

Accurate Clinical Mangemnt - Partner, Houston

Accurate Clinical Research, Inc., Houston

77375

DM Clinical Research, Tomball

77382

Advanced Rheumatology of Houston, The Woodlands

77429

Pioneer Research Solutions, Inc., Cypress

77521

Accurate Clinical Management., LLC, Baytown

77573

Accurate Clinical Research, Inc., League City

77900

CTCenter MaVe s.r.o., Olomouc

78213

Centro de Alta Especialidad en Reumatología e Investigación del Potosí, S.C., San Luis Potosí City

78229

Dr Alex De Jesus Rheumatology, P.A., San Antonio

78731

Austin Regional Clinic, P.A., Austin

79124

Amarillo Center for Clinical Research, Amarillo

79410

West Texas Clinical Research, Lubbock

80020

Centro de Reumatologia y Ortopedia SAS, Barranquilla

80230

Denver Arthritis Clinic, Denver

83404

Institute of Arthritis Research, Idaho Falls

85032

Arizona Arthritis & Rheumatology Associates, P.C., Phoenix

85210

AZ Arthritis & Rheum' Research, Mesa

85351

Arizona Arthritis & Rheumatology Research, PLLC, Sun City

87114

Lovelace Scientific Resources, Inc., Albuquerque

90602

Medvin Clinical Research, Whittier

90623

Advanced Medical Research, LLC, La Palma

91307

Center for Rheumatology Research, Comprehensive Rheumatology Center, West Hills

91722

Medvin Clinical Research, Covina

91786

Inland Rheumatology Clinical Trials, Inc., Upland

92128

Rheumatology Center of San Diego, San Diego

92288

Klaipeda University Hospital, Public Institution, Klaipėda

92543

C.V Mehta MD Med Corp.., Hemet

94304

Stanford University School of Medicine, Palo Alto

94578

East Bay Rheumatology Medical Group, Inc., San Leandro

99204

Arthritis Northwest, PLLC, Spokane

110221

Centro de Investigacion en Reumatologia y Especialidades Medicas SAS. CIREEM, Bogotá

111211

Fundacion Instituto de Reumatologia Fernando Chalem, Bogotá

111539

"State Budgetary Healthcare Institution City Clinical Hospital # 15 n.a O.M. Filatov of Moscow Healtheare Department", Moscow

115093

"SBHI of Moscow City Clinical Hospital #4 of Moscow Healthcare Departament", Moscow

115522

"FSBSI Scientific Research Institute of Rheumatology n.a. V.A. Nasonova", Moscow

119049

"SBHI of Moscow City Clinical Hospital No.1 n.a. Pirogov Healthcare Department of Moscow", Moscow

119435

"FSAEI HE First MSMU n.a. I.M. Sechenov of the Ministry of Health of the Russian Federation University Clinical Hospital No.1", Moscow

119991

"FSAEI HE First MSMU n.a. I.M. Sechenov of the Ministry of Health of the Russian Federation", Moscow

"FSAEI HE First MSMU n.a. I.M. Sechenov of the Ministry of Health of the Russian Federation", Moscow

150003

"State Autonomous Helthcare Institution of Yaroslavl region Clinical Hospital of Emergency Care n.a. Solovyev", Yaroslavl

150062

"SBHI Yaroslavl Regional Clinical Hospital, Rheumatology department", Yaroslavl

185019

"SBHI of the Republic of Karelia Republican Hospital named after V.A. Baranov", Petrozavodsk

190068

"SPb SBHI Clinical Rheumatological Hospital #25, Fourth Rheumatology Unit", Saint Petersburg

197341

"FSBI National Medical Research Center n.a. V.A.Almazov of the Ministry of Healthcare of the Russian Federation", Saint Petersburg

210037

Vitebsk Clinical Hospital, Vitebsk

214025

"Private Healthcare Institution Clinical Hospital Russian Railways-Medicine of City Smolensk", Smolensk

220013

Minsk City Clinical Hospital #1, Minsk

300053

"State Healthcare Institution of Tula region Tula Regional Clinical Hospital", Tula

305007

"Budgetary Healthcare Institution Kursk Regional Clinical Hospital of Healthcare Committee of Kursk region", Kursk

344022

"FSBEI HE Rostov State Medical Unversity of Ministry of Health of the Russian Federation", Rostov-on-Don

355030

"FSBEI HE StSMU MOH Russia based on SBHI of Stavropol Region Stavropol Regional Clinical Hospital", Stavropol

390026

"FSBEI HE 'Ryazan State Medical University n.a. I.P.Pavlov of the Ministry of Health of Russian Federation", Ryazan

410012

"FSBEI HE Saratov SMU n.a. V.I.Razumovsky of Ministry of Health of Russian Federation", Saratov

410053

"State Healthcare Institution Regional Clinical Hospital", Saratov

420012

"FSBEI HE Kazan State Medical University of the Ministry of Health of the Russian Federation on the base of SAHI Republican Clinical Hospital of the Ministry of Health of Tatarstan Republic", Kazan'

432063

"State Healthcare Institution Ulyanovsk Regional Clinical Hospital", Ulyanovsk

450005

"State Budgetary Healthcare Institution Republican Clinical Hospital n.a. G.G. Kuvatov", Ufa

600023

"SBHI of Vladimir Region Regional Clinical Hospital, Rheumatology Departament", Vladimir

603005

"SBHI of Nizhegorodsky Region State Clinical Hospital #5 of Nizhegorodsky District of Nizhny Novgorod", Nizhny Novgorod

603126

"SBHI of Nizhny Novgorod Region Nizhny Novgorod Regional Clinical Hospital n.a.Semashko", Nizhny Novgorod

620102

"State Autonomous Healthcare Institution of Sverdlovsk Region Sverdlovsk Regional Clinical Hospital No.1", Yekaterinburg

620149

"FSBEI HE Ural State Medical University of Ministry of Health of Russian Federation based on MBI Central City Clinical Hospital No.6", Yekaterinburg

630005

"State Autonomous Healthcare Institution of Novosibirsk region City Polyclinic #1", Novosibirsk

644024

"LLC Clinical Diagnostic Center Ultramed", Omsk

644111

"Budgetary Healthcare Institution of Omsk Region Regional Clinical Hospital", Omsk

650000

"SAHI of Kemerovo region Regional Clinical Hospital for War Veterans", Kemerovo

650066

"Medical Center LLC Maksimum Zdoroviya", Kemerovo

656038

"FSBEI HE Altai State Medical University of the Ministry of Healthcare of Russian Federation", Barnaul

680003

Medicity S.A.S., Bucaramanga

90720-5403

Valerius Medical Group, Los Alamitos

06606

New England Research Associates LLC, Bridgeport

01605

Clinical Pharmacology Study Group, Worcester

07728

Arthritis & Osteoporosis Associates, PA, Freehold

B7600FYK

Centro de Investigaciones Medicas Mar del Plata, Mar del Plata

B1878DVB

Instituto Medico CER, Quilmes

B1878GEG

Instituto de Investigaciones Clinicas Quilmes, Quilmes

S2600KUE

Sanatorio San Martin, Venado Tuerto

T4000AXL

Centro Medico Privado de Reumatologia, San Miguel de Tucumán

B7600FZN

Instituto de Investigaciones Clinicas-Mar del Plata, Buenos Aires

C1015ABO

Organizacion Medica de Investigacion (OMI), Ciudad Autonoma Buenos Aires

C1046AAQ

APRILLUS Asistencia e Investigacion, Ciudad Autonoma Buenos Aires

C1204AAD

Instituto Centenario, Ciudad Autonoma Buenos Aires

X5003DCE

Instituto DAMIC Fundacion Rusculleda, Córdoba

T4000BRD

Centro de Investigaciones Reumatológicas, San Miguel de Tucumán

S2000CFJ

Clinica de Higado y Aparato Digestivo, Santa Fe

60430-370

HUWC - UFC - Hospital Universitário Walter Cantídio - Universidade Federal do Ceará, Fortaleza

29055-450

CEDOES - Diagnóstico e Pesquisa, Vitória

74110-120

CIP - Centro Internacional de Pesquisa, Goiânia

36010-570

CMiP - Centro Mineiro de Pesquisa, Juiz de Fora

80030-110

CETI - Centro de Estudos em Terapias Inovadoras Ltda., Curitiba

87013-250

Clinilive - Clínica do Idoso e Pesquisa Clínica, Maringá

95900-010

Hospital Bruno Born, Lajeado

90480-000

LMK Serviços Médicos S/S Ltda, Pôrto Alegre

88301-215

Clínica de Neoplasias Litoral Ltda., Itajaí

09060-650

Faculdade de Medicina do ABC, Santo André

09715-090

Centro Multidisciplinar de Estudos Clínicos - CEMEC, São Bernardo do Campo

20241-180

CCBR Brasil Centro de Pesquisas e Análises Clínicas Ltda., Rio de Janeiro

01228-200

CPCLIN - Centro de Pesquisas Clínicas Ltda., São Paulo

04032-060

Associação de Assistência à Criança Deficiente - AACD, São Paulo

602 00

CCR Brno s.r.o, Brno

IMEDICA s.r.o., Brno

638 00

Revmatologie s.r.o., Brno

586 01

Nemocnice Jihlava p.o., Jihlava

272 01

MUDr Gabriela Simkova Ordinace Lekare Specialisty Interna Revmatologie, Kladno

722 00

ARTROSCAN s.r.o., Ostrava - Trebovice

530 02

ARTHROHELP s.r.o., Pardubice

CCR Czech, a.s., Pardubice

110 00

CLINTRIAL s.r.o., Prague

128 00

Revmatologicky ustav, Prague

130 00

CCR Prague s.r.o., Prague

140 00

MUDR Zuzana URBANOVA Revmatologie, Prague

MUDR Zuzana URBANOVA Revmatologie, Praha 4 Nusle

148 00

Affidea Praha s.r.o., Prague

150 06

Fakultni nemocnice v Motole, Prague

686 01

Medical Plus s.r.o., Uherské Hradiště

760 01

PV - MEDICAL, s.r.o., Zlín

LV-3401

Dr.Saulite-Kandevica Private Practice, Liepāja

LT-01117

Center Outpatient Clinic, Public Institution, Vilnius

LT-08661

Vilnius University Hospital Santariskiu Clinics, Public Institution, Vilnius

15-270

CERMED, Bialystok

15-351

ZDROWIE Osteo-Medic, Bialystok

85-168

Szpital Uniwersytecki nr 2 im.dr J. Biziela, Bydgoszcz

05-825

MCBK Iwona Czajkowska Anna Podrażka- Szczepaniak S.C., Grodzisk Mazowiecki

25-355

Polimedica Centrum Badań, Profilaktyki I Leczenia, Kielce

90-368

CCBR - Lodz - PL, Lodz

91-363

Centrum Medyczne AMED, Lodz

10-117

ETYKA Osrodek Badan Klinicznych, Olsztyn

98-200

Szpital Wojewodzki im. Prymasa Kardynala Stefana Wyszynskiego, Sieradz

96-100

Clinmed Research, Skierniewice

96-500

RCMed, Sochaczew

28-200

KO-MED Centra Kliniczne Staszow, Staszów

22-600

Samodzielny Publiczny ZOZ Tomaszow Lubelski, Tomaszów Lubelski

87-100

Nasz lekarz Przychodnie Medyczne, Torun

00-874

Medycyna Kliniczna, Warsaw

02-118

Rheuma Medicus Zaklad Opieki Zdrowotnej, Warsaw

02-777

McM Polimedica, Warsaw

22-400

KO-MED Centra Kliniczne Zamosc, Zamość

95-100

Santa Familia Centrum Badan, Profilaktyki i Leczenia, Zgierz

431-796

Hallym University Sacred Heart Hospital, Anyang-si

443-380

Ajou University Hospital, Suwon

501-757

Chonnam National University Hospital, Gwangju

120-752

Severance Hospital, Yonsei University No. 31 Office, Pediatric Oncology Clinic, Seoul

TQ2 7AA

Torbay Hospital, Torquay

E11 1NR

Whipps Cross University Hospital, London

NW3 2QG

Royal Free Hospital, London

RG24 9NA

Basingstoke and North Hampshire Hospital, Basingstoke

ME16 9QQ

Maidstone Hospital, Maidstone

L49 5PE

Arrowe Park Hospital, Metropolitan Borough of Wirral

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

IQVIA Pvt. Ltd

INDUSTRY

collaborator

OCT Clinical Trials

OTHER

lead

R-Pharm International, LLC

INDUSTRY

NCT03120949 - Efficacy and Safety of Olokizumab in Subjects With Moderately to Severely Active Rheumatoid Arthritis | Biotech Hunter | Biotech Hunter