Mitoxantrone, Etoposide, and Cytarabine (MEC) Plus Lenalidomide for Relapsed or Refractory Acute Myeloid Leukemia

PHASE2CompletedINTERVENTIONAL
Enrollment

41

Participants

Timeline

Start Date

September 25, 2017

Primary Completion Date

August 29, 2019

Study Completion Date

August 18, 2021

Conditions
AML
Interventions
DRUG

Etoposide

A Drug that interfere with the action of topoisomerase enzymes (topoisomerase I and II). Topoisomerase enzymes control the manipulation of the structure of DNA necessary for replication.

DRUG

Cytarabine

Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA.

DRUG

Lenalidomide

It may act by inhibiting the growth of new blood vessels (angiogenesis) in tumors, enhancing the status of the immune system, or decreasing cytokine and growth factor production

DRUG

Mitoxantrone

It interfere with cell reproduction

Trial Locations (3)

02062

Dana Farber Cancer Institute, Boston

02215

Beth Israel Deaconess Medical Center, Boston

Massachusetts general Hospital, Boston

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Celgene

INDUSTRY

lead

Massachusetts General Hospital

OTHER