Study of Front Line Therapy With Nivolumab and Salvage Nivolumab + Ipilimumab in Patients With Advanced Renal Cell Carcinoma

PHASE2CompletedINTERVENTIONAL
Enrollment

164

Participants

Timeline

Start Date

April 24, 2017

Primary Completion Date

March 25, 2022

Study Completion Date

January 23, 2025

Conditions
Advanced Renal Cell Carcinoma
Interventions
DRUG

Nivolumab 240 mg

PART A Nivolumab 240 mg IV every 2 weeks x 6 then initial disease assessment

DRUG

Ipilimumab 1mg/kg

Ipilimumab 1 mg/kg every 3 weeks x 4

DRUG

Nivolumab 3mg/kg

In combination with Ipilimumab

DRUG

Nivolumab 360mg

Continue Nivolumab 360 mg IV every 3 weeks

Trial Locations (12)

10032

Columbia University, New York

19104

Univeristy of Pennsylvania, Philadelphia

19111

Fox Chase Cancer Center, Philadelphia

20057

Georgetown University, Washington D.C.

30322

Winship Cancer Institute of Emory University, Atlanta

44915

Cleveland Clinic, Cleveland

60611

Northwestern University Feinberg Schooll Of Medicine, Chicago

60612

University of Illinois Cancer Center, Chicago

75390

University of Texas Southwestern Medical Center, Dallas

06520

Yale University, Yale Cancer Center, New Haven

02215

Beth Isreal Deaconess Medical Center, Boston

07601

Hackensack University Medical Center, Hackensack

All Listed Sponsors
collaborator

Bristol-Myers Squibb

INDUSTRY

collaborator

Hoosier Cancer Research Network

OTHER

lead

Michael B. Atkins, MD

OTHER