Accelerated TMS to a Novel Brain Target in MDD and PTSD

NACompletedINTERVENTIONAL
Enrollment

50

Participants

Timeline

Start Date

April 20, 2017

Primary Completion Date

December 1, 2021

Study Completion Date

December 1, 2021

Conditions
Post Traumatic Stress DisorderMajor Depressive Disorder
Interventions
DEVICE

Transcranial Magnetic Stimulation (TMS)

Transcranial Magnetic Stimulation (TMS) is a non-invasive form of brain stimulation. TMS can influence activity in various brain regions, and it allows researchers to test or modify brain circuit communication. In this study, we used administered theta burst TMS stimulation.

BEHAVIORAL

Task

Subject completes a working memory task (Letter Nback) between the two rounds of theta burst stimulation.

PROCEDURE

fMRI-guided TMS target

Administration of TMS to individualized targeting from the participant's fMRI scans. Our preliminary data suggest this target region is particularly effective at influencing the sgACC.

Trial Locations (1)

19104

University of Pennsylvania, Philadelphia

All Listed Sponsors
collaborator

Cures Within Reach

OTHER

lead

University of Pennsylvania

OTHER

NCT03114891 - Accelerated TMS to a Novel Brain Target in MDD and PTSD | Biotech Hunter | Biotech Hunter