Bortezomib, Selinexor, and Dexamethasone in Patients With Multiple Myeloma

PHASE3CompletedINTERVENTIONAL
Enrollment

402

Participants

Timeline

Start Date

May 24, 2017

Primary Completion Date

February 18, 2020

Study Completion Date

May 12, 2022

Conditions
Multiple Myeloma
Interventions
DRUG

Selinexor

oral 100 mg dose

DRUG

Bortezomib

subcutaneous dose of 1.3 mg/m2

DRUG

Dexamethasone

oral dose of 20mg

Trial Locations (157)

1000

Jules Bordet Institute, Brussels

1090

Medical University of Vienna, Vienna

1130

General Hospital Hietzing, Vienna

1160

Wilhelminen Hospital, Department of Internal Medicine I, Center for Oncology & Hematology, Vienna

1307

Group Practice for Hematology and Oncology, Dresden

1431

University Multiprofile Hospital for Active Treatment, Sveti Ivan Rilski Clinic of Hematology, Sofia

1756

Specialized Hospital for Active Treatment of Hematological Diseases, Clinic of Hematology, Dept. of Clinical Hematology, Sofia

2298

Calvary Mater Newcastle, Waratah

2610

St. Augustinus Hospital, Wilrijk

3004

The Alfred Hospital, Melbourne

3065

St. Vincent's Hospital Melbourne, Fitzroy

4002

University Multiprofile Hospital for Active Treatment, Sveti Georgi Clinic of Clinical Hematology, Plovdiv

4029

Royal Brisbane and Women's Hospital, Herston

4101

Mater Misericordiae Limited and Mater Medical Research, South Brisbane

4215

Gold Coast University Hospital, Southport

5000

Royal Adelaide Hospital, Adelaide

5042

Flinders Medical Centre, Bedford Park

7400

Kaposi Mor Teaching Hospital, 2nd Department of Internal Medicine, Kaposvár

7624

Medical Center of the University of Pecs, Department of Hematology, Pécs

8800

General Hospital Delta, Roeselare

9000

University Hospital Ghent, Ghent

10008

O.F. Herbachevskyi Regional Clinical Hospital, Hematology Department with Intensive Therapy Wards, Zhytomyr

10029

Mount Sinai, New York

10126

University Hospital San Giovanni Battista of Turin, Turin

11000

Clinical Center of Serbia, Clinic of Hematology, Belgrade

Institute of Oncology and Radiology of Serbia, Clinic of Medical Oncology, Belgrade

11528

Alexandra General Hospital, Therapeutic Clinic, Athens

11576

The Cancer Institute at St. Francis Hospital, Roslyn

16132

University Hospital San Martino, IRCCA, Dept. of Integrative Cancer Therapies, Operative Unit of Clinical Hematology, Genoa

18009

Cherkasy Regional Oncology Center, Regional Treatment and Diagnostic Hematology Center, Department of Hematology, Cherkasy

20162

Hospital Niguerda Ca Granda, Department of Hematology and Oncology, Hematology Unit, Milan

21018

Vinnytsia M.I. Pyrohov Regional Clinical Hospital, Department of Hematology, Vinnytsia

21201

University of Maryland, Baltimore

24127

ASST Papa Giovanni XXIII, Bergamo

27103

Novant-Forsyth Memorial Hospital, Winston-Salem

28301

University Hospital Infanta Leonor, Department of Hematology, Madrid

29621

SCOR AnMed Health Cancer Center, Anderson

30322

Emory University, Atlanta

33324

Boca Raton Clinical Research (BRCR) Medical Center, Plantation

37007

University Clinical Hospital of Salamanca, Department of Hematology, Salamanca

38320

University Hospital of the Canary Islands, San Cristóbal de La Laguna

40138

Polyclinic S. Orsola-Malpighi, Department of Hematology, Oncology and Laboratory Medicine, Operative Unit of Hematology - Cavo, Bologna

40202

Norton Cancer Institute, Louisville

40422

Commonwealth Hematology, Danville

41013

University Hospital Virgen del Rocio (HUVR), Seville

44093

Nantes University Hospital Center, Nantes

45267

University of Cincinnati Health, Cincinnati

49100

Rabin Medical Center, Petah Tikva

50010

McFarland Clinic, Ames

50134

University Hospital Careggi, Department of Hematology, Florence

51375

Klinikum Leverkusen gGmbH Medizinisxhe Klinik 3, Leverkusen

54511

Brabois Adults Hospital, University Hospital Center of Nancy, Nancy

54639

Theageneion Cancer Hospital, Hematology Department, Thessaloniki

57201

Prairie Lakes Healthcare, Watertown

59037

Claude Huriez Hospital, Lille

60131

Azienda Ospedaliero-Universitaria Ospedali Riuniti, Ancona

65613

Central Care Cancer Center, Bolivar

66606

Stormont Vail Health Care (Cotton O'Neil Cancer Center ), Topeka

69002

South Lyon Hospital Center, Lyon

73505

Southwest Cancer Center of Oklahoma, Lawton

75015

Necker Children's Hospital, Department of Adult Hematology, Paris

75246

Baylor Sammons Cancer Center, Dallas

75390

University of Texas Southwestern, Dallas

75475

Saint-Louis Hospital, Paris

79044

Institute of Blood Pathology and Transfusion Medicine, Department of Hematology with Laboratory Group, Lviv

85925

Hospital Center Departmental La Roche-Sur-Yon, La Roche-sur-Yon

86021

Miletrie Hospital, University Hospital Center of Poitiers, Poitiers

96817

Kaiser Permanente Hawaii, Honolulu

97210

Kaiser Permanente Northwest OR, Portland

110085

Rajiv Gandhi Cancer Hospital, New Delhi

125284

S.P. Botkin City Clinical Hospital, Moscow

129128

N.A. Semashko Central Clinical Hospital #2 under OJSC Russian Railways, Moscow

141001

Dayanand Medical College & Hospital, Ludhiana

160012

Postgraduate Institute of Medical Education & Research (PGIMER), Chandigarh

197022

First I.P. Pavlov State Medical University of St. Petersburg, Saint Petersburg

197341

V.A. Almazov North-West Federal Medical Research Center, Chemotherapy of Oncohematology Diseases and Bone Marrow Transplantation Department #1, Saint Petersburg

226003

King George's Medical University, Lucknow

400010

Prince Aly Khan Hospital, Mumbai

400026

Jaslok Hospital and Research Centre, Mumbai

401107

Bhaktivedanta Hospital, Thāne

500082

Yashoda Hospital, Hyderabad

500366

Hyperclnical MedLife PDR Vulturului Brasov, Hematology Department, Brasov

600020

Cancer Institute, Chennai

600026

SRM Institute of Medical Sciences, Chennai

602105

Saveetha Medical College Hospital, Chennai

625020

Asviratham Speciality Hospital, Madurai

625107

Meenakshi Mission Hospital, Madurai

641037

G. Kuppuswamy Naidu Hospital, Coimbatore

695011

Regional Cancer Centre, Thiruvananthapuram

700094

Netaji Subhash Chandra Bose Cancer Research Institute, Kolkata

700120

Nil Ratan Sircar (NRS) Medical College, Kolkata

700160

TATA Memorial Centre, Kolkata

751003

IMS & SUM Hospital, Bhubaneswar

800014

Regional Cancer Centre, Patna

3109601

Rambam Health Care Campus, Haifa

7830604

Barzilai Medical Center, Ashkelon

07652

The Valley Hospital Luckow Pavilion, Paramus

Unknown

Medical University Innsbruck, Department of Internal Medicine V (Hematology and Oncology), Innsbruck

University Hospital Krems, Department of Internal Medicine II, Krems

UCL Saint-Luc, Brussels

"General Hospital of Athens Evangelismos, Department of Hematology and Lymphoma", Athens

University General Hospital of Patra, Pátrai

Hadassah Medical Center, Jerusalem

City Clinical Hospital No.4 of Dnipro City Council, City hematology center, Dnipropetrovsk

BMT Kiev Center, Kiev

Kiev Cancer Institute, Kiev

T2N 4Z6

Tom Baker Cancer Center/ Alberta Health Services, Calgary

T6G 1Z2

Cross Cancer Institute / University of Alberta, Edmonton

V5Z 1M9

Vancouver General Hospital, Vancouver

B3H 2Y9

Queen Elizabeth II Health Sciences Center, Halifax

P3E 5J1

North East Cancer Centre Sudbury, Greater Sudbury

M5G 1X5

Princess Margaret Cancer Research, Toronto

H1T 2M4

Maisonneuve-Rosemont Hospital, Montreal

H3A 1A1

Royal Victoria Hospital / McGill University, Montreal

G1R 2J6

L'Hôtel-Dieu de Québec, Québec

S4T 7TI

Saskatchewan Cancer Agency-Allan Blair Cancer Centre, Regina

S7N 4H4

Saskatoon Cancer Center, Saskatoon

128 08

General University Hospital in Prague, Prague

625 00

University Hopsital Brno, Brno

500 05

University Hospital Hradec Kralove, Hradec Králové

775 20

University Hospital Olomouc, Olomouc

708 52

University Hospital Ostrava, Dept. of Hematooncology, Ostrava

100 34

University Hospital Kralovske Vinohrady, Clinic of Internal Hematology, Prague

D-79106

University Hospital Freiburg, Department of Internal Medicine I, Freiburg im Breisgau

H-1083

Semmelweis University, 1st Department of Internal Medicine, Budapest

H-1097

Integrated Szent Istvan and Szent laszlo Hospital, Department of Hematology and Stem Cell Transplantation, Budapest

H-1125

Semmelweis University, 3rd Department of Internal Medicine, Budapest

05100

Hospital Santa Maria of Terni, Terni

00161

Umberto I Polyclinic of Rome, Department of Cellular Biotechnology and Hematology, Hematology Center, Rome

85-168

Jan Biziel University Hospital #2 in Bydgoszcz, Department of Hematology, Bydgoszcz

41-500

Independent Public Healthcare Facility Municipal Hospital Group in Chorzow, Department of Hematology, Chorzów

31-501

University Hospital in Krakow, Teaching Unit of the Hematology Department, Krakow

93-513

Nicolaus Copernicus Memorial Provincial Specialist Hospital in Lodz, Department of Hematology, Lodz

20-081

Independent Public Teaching Hospital No.1 in Lublin, Department of Hematology-Oncology and Bone Marrow Transplantation, Lublin

20-090

St. John of Dukla Oncology Center of Lublin, Department of Hematology, Lublin

04-141

Military Institute of Medicine, Department of Internal Medicine and Hematology, Warsaw

020125

Colentina Clinical Hospital, Department of Hematology, Bucharest

050098

Bucharest University Emergency Hospital, Department of Hematology, Bucharest

34 000

Clinical Center Kragujevac, Clinic of Hematology, Kragujevac

18 000

Clinical Center Nis, Clinic of Hematology and Clinical Immunology, Niš

21 000

Clinical Center of Vojvodina, Clinic of Hematology, Novi Sad

08916

Catalan Institute of Oncology (ICO) Badalona, Badalona

08035

University Hospital of Vall d'Hebron, Barcelona

BT9 7AB

Belfast Heatlh & Social Care Trust Belfast City Hospital, Belfast

DD1 9SY

NHS Tayside Ninewells Hospital, Dundee

CF14 4XW

Cardiff & Vale University Health Board University Hospital of Wales, Cardiff

B15 2TH

University Hospitals Birmingham NHS Foundation Trust Queen Elizabeth Hospital, Birmingham

LS9 7TF

The Leeds Teaching Hospitals NHS Trust St. James University Hospital, Leeds

LE1 5WW

University Hospitals of Leicester NHS Trust Royal Leicester Infirmary, Leicester

L7 8XP

Royal Liverpool & Broadgreen University Hospital NHS Trust Royal Liverpool University Hospital, Liverpool

HA1 3UJ

London North West Healthcare NHS Trust Northwick Park Hospital, London

NW3 2PF

University College London, London

SE5 9RS

King's College Hospital NHS Foundation Trust, London

W12 0HS

Imperial College Healthcare NHS Trust Hammersmith Hospital, London

M20 4BX

The Christie NHS Foundation Trust, Manchester

NE7 7DN

Freeman Hospital, Newcastle upon Tyne

WV10 0QP

The Royal Wolverhampton NHS Trust New Cross Hospital, Wolverhampton

Sponsors
All Listed Sponsors
lead

Karyopharm Therapeutics Inc

INDUSTRY

NCT03110562 - Bortezomib, Selinexor, and Dexamethasone in Patients With Multiple Myeloma | Biotech Hunter | Biotech Hunter