Study of Milciclib in Patients With Unresectable/Metastatic Hepatocellular Carcinoma

PHASE2CompletedINTERVENTIONAL
Enrollment

31

Participants

Timeline

Start Date

July 12, 2017

Primary Completion Date

May 16, 2019

Study Completion Date

June 20, 2019

Conditions
Hepatocellular Carcinoma
Interventions
DRUG

Milciclib maleate

100 mg/day once daily, for 4 consecutive days a week in a 4-week cycle (4 days on/3 days off x q4 wks) for a total of 12 weeks (i.e. 3 cycles) unless patient refusal, consent withdrawal, Investigator's decision, unacceptable toxicity or death whichever occurs earlier. After the completion of three cycles, patients who, in the Investigator's judgment, are benefiting from treatment with milciclib, will resume treatment and will remain on study up to Day 180 from treatment start, unless withdrawal criteria are met earlier.

Trial Locations (14)

11527

Ippokrateio General Hospital of Athens, Athens

Laiko General Hospital of Athens, Athens

20089

Istituto Clinico Humanitas, Rozzano

20122

Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Milan

31096

Rambam Health Corporation, Haifa

40138

AOU S. Orsola Malpighi Bologna, Bologna

41110

General University Hospital of Larissa, Larissa

41124

Azienda Ospedaliera Universitaria Policlinico di Modena, Modena

54636

University General Hospital of Thessaloniki - AHEPA, Thessaloniki

64239

Tel Aviv Sourasky Medical Center, Tel Aviv

80131

A.O.U. Federico II, Napoli

90127

A.O. U. Policlinico Paolo Giaccone, Palermo

4941492

Rabin Medical Center - Beilinson Hospital, Petah Tikva

Unknown

The Sheba Academic Medical Center Hospital - Tel Hashomer, Ramat Gan

All Listed Sponsors
lead

Tiziana Life Sciences LTD

INDUSTRY

NCT03109886 - Study of Milciclib in Patients With Unresectable/Metastatic Hepatocellular Carcinoma | Biotech Hunter | Biotech Hunter