1,705
Participants
Start Date
April 27, 2017
Primary Completion Date
September 26, 2019
Study Completion Date
September 9, 2024
Adalimumab
Administered by subcutaneous injection
Upadacitinib
Oral tablet
Placebo to Upadacitinib
Oral tablet
Placebo to Adalimumab
Administered by subcutaneous injection
Chung Shan Medical University /ID# 159403, Taichung
Univ Medical Ctr Ljubljana /ID# 164212, Ljubljana
Clinic ORTO /ID# 161486, Riga
Organizacion Medica de Investigacion (OMI) /ID# 160118, Buenos Aires
Betegapolo Irgalmas Rend - Budai Irgalmasrendi Korhaz /ID# 170719, Budapest
Revita Reumatologiai Rendelo /ID# 163277, Budapest
Qualiclinic Kft. /ID# 163278, Budapest III
Obudai Egeszsegugyi Centrum Kft. /ID# 163279, Budapest
Synexus Magyarorszag Kft. /ID# 203012, Budapest
Hospital General de Agudos Ram /ID# 164378, Buenos Aires
Excelsior Medical Center /ID# 169609, Sofia
Psoriahue Med Interdisciplinar /ID# 160506, Buenos Aires
Inst. de Rehab. Psicofisica /ID# 165154, CABA
Multiprofile Hospital for Active Treatment - Sofia at Military Medical Academy /ID# 169608, Sofia
UMHAT Sv. Ivan Rilski /ID# 202393, Sofia
HFR Fribourg - Hopital Canton /ID# 162090, Fribourg
Medical Centre Synexus Sofia /ID# 202394, Sofia
Instituto CAICI /ID# 160119, Rosario, Santa FE
Centro de Enfermedades del Hígado y Aparato Digestivo /ID# 165795, Santa Fe
University Medical Ctr Maribor /ID# 169260, Maribor
Emeritus Research Sydney /ID# 166780, Botany
Middlemore Hospital /ID# 166414, Auckland
Wits Clinical Research Site /ID# 163919, Johannesburg
Heidelberg Repatriation Hospital /ID# 167450, Heidelberg West
Waikato Hospital /ID# 166415, Hamilton
Barwon Rheumatology /ID# 166782, Geelong
D.Saulites-Kandevicas PP in Cardiology and Rheumatology /ID# 161488, Liepāja
Reuma clinic /ID# 164243, Genk
Centro Medico Privado/Reuma /ID# 159775, San Miguel de Tucumán
Centro Integral de Medicina Respiratoria (CIMER) /ID# 211237, San Miguel de Tucumán
Centro Integral de Medicina Re /ID# 160258, SAN Miguel de Tucuman, Latam
Department of Rheumatology, Mu /ID# 169606, Plovdiv
Debreceni Egyetem Kenezy Gyula /ID# 163276, Debrecen
Szabolcs-Szatmar-Bereg Megyei Korhazak & Egyetemi Oktatok.- Klinikai Kutatasi O. /ID# 202584, Nyíregyháza
The Queen Elizabeth Hospital /ID# 169333, Woodville
Synexus Magyarorszag Kft. - Gyula DRS /ID# 202209, Gyula
Medical Centre Synexus Sofia, branch Stara Zagora /ID# 202524, Stara Zagora
Greenacres Hospital /ID# 164190, Port Elizabeth
Helse Forde /ID# 167853, Førde
St. Olavs Hospital HF /ID# 163321, Trondheim
Porter Rheumatology Ltd /ID# 200421, Nelson
Arthritis Clinical Research Tr /ID# 163855, Cape Town
Winelands Medical Research Ctr /ID# 163853, Stellenbosch
Timaru Rheumatology Studies /ID# 166413, Timaru
Vital Medical Center Orvosi-es Fogaszati Kozpont /ID# 163275, Veszprém
Synexus Magyarorszag Kft. - Zalaegerszeg AS /ID# 201884, Zalaegerszeg
Diagnostic Consultative Center /ID# 169607, Varna
General Hospital Murska Sobota /ID# 164211, Murska Sobota
Kantonsspital St. Gallen /ID# 158131, Sankt Gallen
Poliklinika Repromed /ID# 203555, Zagreb
Medical Center Kuna-Peric /ID# 161160, Zagreb
Poliklinika Bonifarm /ID# 206662, Zagreb
National Taiwan University Hospital /ID# 160878, Taipei
Center of Clinical and Basic Research /ID# 163870, Tallinn
East Tallinn Central Hospital /ID# 163790, Tallinn
Institute for Rheumatology /ID# 166217, Belgrade
Institute for Rheumatology /ID# 166223, Belgrade
Institute for Rheumatology /ID# 166229, Belgrade
Institute for Rheumatology /ID# 166231, Belgrade
Military Medical Academy /ID# 166293, Belgrade
Taipei Veterans General Hosp /ID# 166222, Taipei
Naval Hospital of Athens /ID# 163486, Athens
NYU Langone Rheum Assoc /ID# 159985, Lake Success
CINTRE, Centro de Investigación y Tratamiento Reumatológico SC /ID# 164006, Mexico City
University General Hospital Attikon /ID# 163477, Athens
Immanuel-Krankenhaus /ID# 163931, Buch
St. Lawrence Health System /ID# 159848, Potsdam
Hospital Universitario A Coruña - CHUAC /ID# 161129, A Coruña
Ajou University Hospital /ID# 163891, Suwon
Altoona Ctr Clinical Res /ID# 159852, Duncansville
Hospital Campus de la Salud /ID# 170760, Granada
PA Regional Center /ID# 165670, Wyomissing
Hamburger Rheuma Forschungszentrum II im MVZ Rheumatologie und Autoimmunmedizin /ID# 204421, Hamburg
The Center for Rheumatology & Bone Research /ID# 159874, Wheaton
Vinnytsia Regional Clinical Hospital n.a. M.I.Pyrogov /ID# 164245, Vinnytsia
Johns Hopkins University /ID# 167665, Baltimore
Klein & Associates, M.D., P.A. /ID# 164013, Cumberland
Arthritis Clinic of N. VA, P.C /ID# 159849, Arlington
Inha University Hospital /ID# 163890, Junggu
Ctr for Arth and Rheum Disease /ID# 159830, Chesapeake
Dr. med. Jochen Walter FA fuer /ID# 168638, Rendsburg
West Virginia Research Inst /ID# 159791, South Charleston
Shanahan Rheuma & Immuno /ID# 159987, Raleigh
M3-Emerging Medical Research, LLC /ID# 161391, Durham
Physicians East, PA /ID# 159872, Greenville
Hospital Universitario Ramon y Cajal /ID# 161130, Madrid
Hospital Universitario 12 de Octubre /ID# 163198, Madrid
American Health Research /ID# 164354, Charlotte
Cape Fear Arthritis Care /ID# 161224, Leland
Hospital Raja Permaisuri Bainun /ID# 161099, Ipoh
Invest y Biomed de Chihuahua /ID# 164007, Chihuahua City
International Medical Research - Daytona /ID# 160040, Daytona Beach
Millennium Research /ID# 159822, Ormond Beach
Gulf Region Clinical Res Inst /ID# 159851, Pensacola
LeJenue Research Associates /ID# 170965, Miami
Linkou Chang Gung Memorial Ho /ID# 166221, Taoyuan
W. Broward Rheum Assoc Inc. /ID# 161388, Tamarac
Florida Medical Clinic /ID# 159992, Zephyrhills
University of South Florida /ID# 161286, Tampa
BayCare Medical Group /ID# 159792, St. Petersburg
Clinical Res of West FL, Inc. /ID# 159829, Clearwater
Medallion Clinical Research Institute, LLC /ID# 161228, Naples
Bakirkoy Dr. Sadi Konuk Training & Research Hospital /ID# 162517, Istanbul
Arthritis Center, Inc. /ID# 163465, Palm Harbor
Marmara Universitesi Pendik Egitim ve Arastirma Hastanesi /ID# 163383, Istanbul
Rheum Assoc of North Alabama /ID# 163231, Huntsville
Rheumatology Consultants, PLLC /ID# 159796, Knoxville
Dr. Ramesh Gupta /ID# 160061, Memphis
West Tennessee Research Inst /ID# 159871, Jackson
Polikilinik fuer Rheumatologie /ID# 163933, Düsseldorf
China Medical University Hosp /ID# 159402, Taichung
Reg Gen Univ Hosp Larissa /ID# 163496, Larissa
Four Rivers Clinical Research /ID# 159982, Paducah
Necmettin Erbakan Universitesi /ID# 163382, Meram Konya
Graves Gilbert Clinic /ID# 161285, Bowling Green
Azienda Unita Sanitaria Locale/IRCCS c/o Arcispedale Santa Maria Nuova /ID# 161090, Reggio Emilia
The Ohio State University /ID# 159892, Columbus
Clinical Research Source, Inc. /ID# 164545, Perrysburg
MetroHealth Medical Center /ID# 159888, Cleveland
Rheumazentrum Ruhrgebiet /ID# 163930, Herne
Instituto Jalisciense de Metabolismo SC /ID# 164005, Guadalajara
Shores Rheumatology, PC /ID# 159889, Saint Clair Shores
Univ of Michigan Hospitals /ID# 164014, Ann Arbor
Aa Mrc Llc /Id# 159846, Grand Blanc
Advanced Rheumatology, PC /ID# 159893, Lansing
Beals Institute PC /ID# 163128, Lansing
VAKK dr. Kildos Clinic /ID# 167257, Kaunas
MediTrials /ID# 163706, Tartu
Klinicki bolnicki centar Rijeka /ID# 161159, Rijeka
Aurora Rheumatology and Immunotherapy Center /ID# 160043, Franklin
Sakarya Universitesi Egitim /ID# 163397, Sakarya
St. Luke's Hospital of Duluth /ID# 165671, Duluth
Trinity Health Med Arts Clinic /ID# 159800, Minot
Glacier View Research Institut /ID# 167023, Kalispell
Ospedali Riuniti Universita /ID# 161085, Ancona
Deerbrook Medical Associates /ID# 159804, Vernon Hills
Clinical Investigation Specialists - Skokie /ID# 160062, Skokie
Cent fur Innovative Diagnostik /ID# 163927, Frankfurt
Great Lakes Clinical Trials /ID# 163435, Chicago
State Institution L. T. Malaya Therapy National Institution of NAMS of Ukraine /ID# 164170, Kharkiv
Kharkiv Regional Council Regional Clinical Hospital /ID# 210189, Kharkiv
Odessa National Medical Univ /ID# 164244, Odesa
Westroads Clinical Research /ID# 159979, Omaha
Ochsner Clinic Foundation-New Orleans /ID# 165672, New Orleans
Hospital Tuanku Ja afar /ID# 161096, Seremban
Clinical Center University of Sarajevo /ID# 164502, Sarajevo
University General Hospital of Heraklion PA.G.N.I /ID# 163472, Heraklion
Med. Universitaetsklinik Inner /ID# 163929, Tübingen
Little Rock Diagnostics Clinic /ID# 165161, Little Rock
SW Rheumatology Res. LLC /ID# 159993, Mesquite
Metroplex Clinical Research /ID# 159785, Dallas
PCCR Solution /ID# 205723, Colleyville
Public Institution Republican /ID# 165155, Šiauliai
Arthritis & Osteoporosis Clinic /ID# 159786, Waco
Rheumatic Disease Clin Res Ctr /ID# 161240, Houston
Rheumatology Clinic of Houston /ID# 161234, Houston
"DMCR-Texas Cent for Drug Dev /ID# 164191", Houston
DM Clinical Research /ID# 161735, Tomball
Accurate Clinical Management /ID# 159905, Baytown
Diagnostic Group Integrated He /ID# 159794, Beaumont
Arth and Osteo Clin Brazo Valley /ID# 163436, College Station
University Clinical Centre of the Republic of Srpska /ID# 164503, Banja Luka
Arthritis & Osteo Ctr of S. TX /ID# 163784, San Antonio
Adriana Pop-Moody MD Clinic PA /ID# 159984, Corpus Christi
Arthritis Clinic of Central TX /ID# 164049, San Marcos
Lviv Regional Clinical Hospita /ID# 164178, Lviv
Revmatologie Bruntal, s.r.o /ID# 159636, Bruntál
Ctr Int de Reum del Caribe SAS /ID# 164051, Barranquilla
AOU Federico II /ID# 202411, Naples
Colorado Arthritis Associates /ID# 159847, Lakewood
Denver Arthritis Clinic /ID# 159873, Denver
Arthritis and Rheum Clin N. CO /ID# 160039, Fort Collins
Institute of Arthritis Researc /ID# 165873, Idaho Falls
Advanced Clinical Research /ID# 159894, Meridian
AZ Arthritis & Rheuma Research /ID# 160037, Phoenix
SunValley Arthritis Center, Lt /ID# 161221, Peoria
AZ Arth & Rheum Res /ID# 166381, Tucson
Santa Fe Rheumatology /ID# 163783, Santa Fe
University Clinical Hospital Mostar /ID# 165799, Mostar
Arthritis and Osteo Assoc /ID# 159994, Las Cruces
University of California, Los Angeles /ID# 164542, Los Angeles
Medvin Clinical Research /ID# 160034, Whittier
Covina Arthritis Clinic /ID# 159891, Covina
Inland Rheum Clin Trials Inc. /ID# 159828, Upland
Kotha and Kotha /ID# 159823, La Mesa
TriWest Research Associates- La Mesa /ID# 159887, La Mesa
Klaipeda University Hospital /ID# 167258, Klaipėda
C.V. Mehta MD, Med Corporation /ID# 161216, Hemet
Care Access Research, Huntingt /ID# 160038, Huntington Beach
St. Joseph Heritage Healthcare /ID# 159980, Fullerton
East Bay Rheumatology Medical /ID# 166382, San Leandro
"Azienda Ospedaliera Universitaria Policlinico G. Rodolico - San Marco /Id# 161084", Catania
VA Sacramento Medical Center /ID# 164196, Mather
Swedish Medical Center /ID# 159890, Seattle
Arthritis Northwest, PLLC /ID# 166380, Spokane
Peking University Third Hospital /ID# 201973, Beijing
Centro de Investigacion en Reumatologia CIREEM /ID# 166030, Bogota
Moscow S.P.Botkin City Clinica /ID# 164533, Moscow
Family Outpatient clinic#4 LLC /ID# 164530, Korolev
Singapore General Hospital /ID# 161094, Singapore
State budgetary institution /ID# 164532, Saint Petersburg
Huashan Hospital of Fudan University /ID# 202191, Shanghai
Shanghai Changhai Hospital /ID# 200202, Shanghai
The First Affiliated Hospital of Soochow University /ID# 201875, Suzhou
First City Clinical Hospital /ID# 164534, Minsk
Brest Regional Hospital /ID# 164535, Brest
Affiliated hospital of nantong university /ID# 208234, Nantong
Healthcare Institution /ID# 164536, Grodno
1st Aff Hosp of Bengbu Medical College /ID# 201021, Bengbu
Preventive Care Sas /Id# 163781, Chía
The First People's Hospital of Linyi /ID# 201970, Linyi
Tan Tock Seng Hospital /ID# 161095, Singapore
Ningbo First Hospital /ID# 201874, Ningbo
Zhuzhou Central Hospital /ID# 200201, Zhuzhou
Kazan State Medical University /ID# 164531, Kazan'
The First Affiliated Hospital of Shantou University Medical College /ID# 203371, Shantou
West China Hospital /ID# 200199, Chengdu
LLC Medical Center /ID# 164529, Novosibirsk
First Affiliated Hospital of Kunming Medical University /ID# 201264, Kunming
People's Hospital of Xinjiang /ID# 201592, Ürümqi
Prince of Wales Hospital /ID# 163506, Hong Kong
Queen Mary Hospital /ID# 162492, Hong Kong
Tuen Mun Hospital /ID# 162493, Tuenmen
The Lady Davis Carmel MC /ID# 170262, Haifa
Sheba Medical Center /ID# 202532, Ramat Gan
Tel Aviv Sourasky Medical Center /ID# 169845, Tel Aviv
CTR Estudios SpA /ID# 206217, Providencia
Clinica Dermacross S.A /ID# 168726, Vitacura Santiago
M y F Estudios Clínicos Ltda. /ID# 168722, Ñuñoa
Centro Inter Estud Clin CIEC /ID# 168725, Santiago
AZ Arthritis and Rheumotology Research, PLLC /ID# 159981, Phoenix
AZ Arthritis and Rheumotology Research, PLLC /ID# 160033, Phoenix
AZ Arthritis and Rheumotology Research, PLLC /ID# 160036, Phoenix
Arthritis & Osteo Medical Ctr /ID# 166760, La Palma
Stamford Therapeutics Consorti /ID# 165131, Stamford
Omega Research Maitland, LLC /ID# 164193, DeBary
Precision Research Org, LLC /ID# 161287, Miami Lakes
Clinical Research of West Florida, Inc /ID# 160063, Tampa
BayCare Medical Group, Inc. /ID# 159879, Tampa
OrthoIllinois /ID# 164546, Rockford
Tufts Medical Center /ID# 165144, Boston
Mansfield Health Center /ID# 159805, Mansfield
Clinical Pharmacology Study Gr /ID# 158700, Worcester
Clinvest Research LLC /ID# 161227, Springfield
Clayton Medical Associates dba Saint Louis Rheumatology /ID# 159878, St Louis
Dartmouth-Hitchcock Medical Center /ID# 161235, Lebanon
Arthritis and Osteoporosis Associates /ID# 159802, Freehold
Atlantic Coast Research /ID# 159799, Toms River
Ocean Rheumatology, PA /ID# 163898, Toms River
NYU Langone Medical Center /ID# 163230, New York
DJL Clinical Research, PLLC /ID# 161390, Charlotte
STAT Research, Inc. /ID# 161392, Vandalia
Health Research of Oklahoma /ID# 159880, Oklahoma City
Articularis Healthcare Group, Inc d/b/a Low Country Rheumatology /ID# 163464, Summerville
West Texas Clinical Research /ID# 205722, Lubbock
P&I Clinical Research /ID# 159826, Lufkin
Trinity Universal Research Association /ID# 205721, Plano
Instituto de Ciencias Farmacêuticas /ID# 163274, Aparecida de Goiânia
CIP - Centro Internacional de Pesquisa /ID# 161821, Goiânia
CMiP - Centro Mineiro de Pesquisa Ltda - ME /ID# 161819, Juiz de Fora
EDUMED Educacao em Saude S/S L /ID# 161816, Curitiba
Instituto de Educação e Pesquisa do Hospital Moinhos de Vento /ID# 161813, Porto Alegre
Hospital de Clinicas de Porto Alegre /ID# 161820, Porto Alegre
LMK Sevicos Medicos S/S /ID# 161812, Porto Alegre
Hospital das Clinicas da Faculdade de Medicina de Ribeirão Preto - USP /ID# 163273, Ribeirão Preto
Faculdade de Medicina do ABC /ID# 163491, Santo André
CEMEC - Centro Multidisciplinar de Estudos Clínicos do ABC /ID# 161810, Santo André
CPCLIN - Centro de Pesquisas Clínicas /ID# 161818, São Paulo
Percuro Clinical Research, Ltd /ID# 157823, Victoria
Manitoba Clinic /ID# 157829, Winnipeg
Ciads /Id# 157831, Winnipeg
The Waterside Clinic /ID# 157826, Barrie
Groupe de Recherche en Maladies Osseuses Inc /ID# 157824, Sainte-Foy
Ctr. de Recherche Musculo-Sque /ID# 207069, Trois-Rivières
Prosalud Ltda. /ID# 169546, Santiago
The First Affiliated Hospital of Baotou Medical College, Inner Monggolia Univers /ID# 171204, Baotou
The Aff Hosp Inner Mongolia /ID# 207787, Hohhot
Fundacion Centro de Investigac /Id# 168201, Antioquia
Hospital Pablo Tobon Uribe /ID# 164233, Medellín
Revmatologicka ambulance /ID# 159637, Prague
Revmatologicka ambulance /ID# 159671, Prague
Artroscan s.r.o. /ID# 159634, Ostrava
Medical Plus, s.r.o. /ID# 159635, Uherské Hradište
University Clinic Carl Gustav /ID# 163926, Dresden
General Hospital of Athens Laiko /ID# 163476, Athens
General Hospital of Athens Laiko /ID# 163478, Athens
St Vincent's University Hosp /ID# 161073, Dublin
Croom Orthopaedic Hospital /ID# 164998, Limerick
Policlinico Universitario Campus Bio-Medico /ID# 162306, Rome
Nagoya City University Hospital /ID# 162564, Nagoya
Fukuoka University Hospital /ID# 162086, Fukuoka
Hospital of the University of Occupational and Environmental Health /ID# 161473, Kitakyushu-shi
Mie University Hospital /ID# 162080, Tsu
National Hospital Organization Osaka Minami Medical Center /ID# 162590, Kawachinagano-shi
St.Luke's International Hospital /ID# 162016, Chuo-ku
M &M Centrs /Id# 161483, Ādaži
P. Stradins Clinical Univ Hosp /ID# 164442, Riga
Vilnius University Hospital /ID# 165123, Vilnius
Medisch Centrum Leeuwarden /ID# 161575, Leeuwarden
Erasmus Medisch Centrum /ID# 161092, Rotterdam
Maasstad Ziekenhuis /ID# 160168, Rotterdam
North Shore Hospital /ID# 169409, Auckland
NZOZ Nasz Lekarz /ID# 163774, Torun
Malopolskie Centrum Kliniczne /ID# 163777, Krakow
Synexus Polska Sp. z o.o. /ID# 204506, Wroclaw
Synexus Polska Sp. z o.o. Oddzial w Gdansku /ID# 206299, Gdansk
Synexus Polska Sp. z o.o. Oddzial w Gdyni /ID# 207157, Gdynia
Synexus Polska Sp. z o.o. Oddzial Katowice /ID# 204510, Katowice
ETYKA-Osrodek Badan Klinicznyc /ID# 163776, Olsztyn
Centrum Kliniczno-Badawcze /ID# 161830, Elblag
Krakowskie Centrum Medyczne /ID# 206302, Krakow
Synexus Polska Sp. z o.o. Oddzial w Poznaniu /ID# 207158, Poznan
Medycyna Kliniczna /ID# 166288, Warsaw
Synexus Polska Sp. z.o.o. /ID# 203987, Warsaw
Reumatika - Centrum Reumatologii NZOZ /ID# 161831, Warsaw
Salve Medica Sp. z o.o. S.K. /ID# 206300, Lodz
Instituto Portugues De Reumatologia /ID# 165858, Lisbon
Centro Hospitalar Lisboa Ocidental, EPE /ID# 165861, Lisbon
Centro Hospitalar de Vila Nova Gaia/Espinho, EPE /ID# 165862, Vila Nova de Gaia
Centro Hospitalar Lisboa Norte, EPE /ID# 165860, Lisbon
Hospital CUF Descobertas /ID# 165866, Lisbon
Hospital Beatriz Angelo /ID# 165865, Loures
Unidade Local De Saude Do Alto Minho /ID# 165863, Viana do Castelo
Cruz-Santana, Carolina, PR /ID# 163307, Carolina
Ponce Medical School Foundation /ID# 163920, Ponce
GCM Medical Group, PSC /ID# 162160, San Juan
MEDMAN s.r.o. /ID# 165892, Martin
Reumatologická ambulancia Reum.hapi s.r.o. /ID# 166486, Nové Mesto nad Váhom
Slovak research center Team Member, Thermium s.r.o. /ID# 166489, Pieštany
University of Pretoria /ID# 163852, Pretoria
Jakaranda Hospital /ID# 164242, Pretoria
Cukurova Universitesi Tip Fakultesi /ID# 162516, Saricam Adana
Hacettepe Universitesi Tip Fak /ID# 162518, Sihhiye
NSC Strazhesko Ist Cardiology /ID# 164043, Kiev
Med Ctr of Private High Ed Ins /ID# 208527, Kyiv
Medical Center of LLC Medbud-Clinic /ID# 208528, Kyiv
Kyiv Railway Clinical Hosp No.2 /ID# 208951, Kyiv
LLC Revmocentr /ID# 164177, Kyiv
MNI KRC Kyiv Regional Clinical Hospital /ID# 210188, Kyiv
Whipps Cross Univ Hospital /ID# 161055, London
Guy's and St Thomas' NHS Found /ID# 161065, London
Christchurch Hospital /ID# 162702, Christchurch
UH Coventry & Warwickshire /ID# 162701, Coventry
Glasgow Royal Infirmary /ID# 162703, Glasgow
Luton & Dunstable University Hospital /ID# 162704, Luton
Lead Sponsor
AbbVie
INDUSTRY