"Efficacy and Tolerability of Nebicapone in Parkinson's Disease Patients With Wearingoff Phenomenon"

200 mg entacapone were to be taken concomitantly with each levodopa/DDCI dose.

50 mg, 100 mg and 150 mg doses of nebicapone were to be taken concomitantly with each levodopa/DDCI dose.

"Prior to the study, all patients were to have been receiving levodopa/DDCI therapy for at least 1 year with clear clinical improvement. At entry to the study, patients were to be receiving levodopa/DDCI therapy of at least 4 but not more than 8 (inclusive) standard daily doses.~All patients were to continue receiving levodopa/DDCI during the study. Levodopa and DDCI were prescribed by the investigators and purchased locally by patients."

Administered orally as encapsulated tablets, which were identical in appearance to the study drugs