Leukotriene A4 Hydrolase Stratified Trial of Adjunctive Corticosteroids for HIV-uninfected Adults With Tuberculous Meningitis

PHASE3CompletedINTERVENTIONAL
Enrollment

702

Participants

Timeline

Start Date

February 12, 2018

Primary Completion Date

March 9, 2023

Study Completion Date

March 9, 2024

Conditions
TuberculosisTuberculous MeningitisDrug-Induced Liver Injury
Interventions
DRUG

Dexamethasone

Active treatment with dexamethasone from randomisation (IV followed by oral according to disease severity at the start of treatment): Dexamethasone for intravenous injection and dexamethasone for oral ingestion

OTHER

Placebo

Treatment with matched placebo: Standard saline for intravenous injection and placebo oral tablets containing cellulose

Trial Locations (3)

Unknown

Hospital for Tropical Diseases, Ho Chi Minh City

Oxford University Clinical Research Unit, Ho Chi Minh City

Pham Ngoc Thach Hospital, Ho Chi Minh City

All Listed Sponsors
collaborator

Pham Ngoc Thach Hospital, Ho Chi Minh City, Vietnam

OTHER

collaborator

Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam

OTHER

lead

Oxford University Clinical Research Unit, Vietnam

OTHER

NCT03100786 - Leukotriene A4 Hydrolase Stratified Trial of Adjunctive Corticosteroids for HIV-uninfected Adults With Tuberculous Meningitis | Biotech Hunter | Biotech Hunter