NCT03098680View on ClinicalTrials.gov

A Study of the Pharmacokinetic and Pharmacodynamic Responses in Healthy and Altered Human Cardiovascular Systems

PHASE1TerminatedINTERVENTIONAL
Enrollment

18

Participants

Timeline

Start Date

April 24, 2017

Primary Completion Date

February 29, 2020

Study Completion Date

February 29, 2020

Conditions
Drug-Related Side Effects and Adverse ReactionsCardiovascular System Disease
Interventions
DRUG

Albuterol Sulfate

see arm/group descriptions

DRUG

Nicardipine Hydrochloride

see arm/group descriptions

DRUG

Dobutamine Hydrochloride

see arm/group descriptions

DRUG

Phenylephrine Hydrochloride

see arm/group descriptions

DRUG

Verapamil Hydrochloride

see arm/group descriptions

DRUG

Phentolamine Mesylate

see arm/group descriptions

DRUG

Placebo

see arm/group descriptions

Trial Locations (1)

CB2 0QQ

Addenbrooke's Hospital, Cambridge

Sponsors

Collaborators (1)

AstraZeneca
All Listed Sponsors
collaborator

University of Cambridge

OTHER

collaborator

AstraZeneca

INDUSTRY

lead

Cambridge University Hospitals NHS Foundation Trust

OTHER