NCT03096782 - Umbilical Cord Blood Transplant With Added Sugar and Chemotherapy and Radiation Therapy in Treating Patients With Leukemia or Lymphoma | Biotech Hunter

Enrollment

Participants

Timeline

Start Date

October 13, 2017

Primary Completion Date

September 20, 2022

Study Completion Date

September 20, 2022

Conditions

Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 PositiveAcute Biphenotypic LeukemiaAcute LeukemiaAcute Lymphoblastic LeukemiaAcute Lymphoblastic Leukemia in RemissionAcute Myeloid LeukemiaAcute Myeloid Leukemia Arising From Previous Myelodysplastic SyndromeChemotherapy-Related LeukemiaChronic Lymphocytic LeukemiaChronic Myelogenous Leukemia, BCR-ABL1 PositiveChronic Myelomonocytic LeukemiaHodgkin LymphomaLangerhans Cell HistiocytosisMinimal Residual DiseaseMyelodysplastic SyndromeMyelodysplastic Syndrome With Excess BlastsNon-Hodgkin LymphomaRecurrent Hodgkin LymphomaRefractory Acute Lymphoblastic LeukemiaRefractory Myelodysplastic SyndromeSmall Lymphocytic LymphomaTherapy-Related Myelodysplastic Syndrome

Interventions

BIOLOGICAL

Anti-Thymocyte Globulin

Given IV

DRUG

Busulfan

Given IV

DRUG

Clofarabine

Given IV

DRUG

Cyclophosphamide

Given IV

BIOLOGICAL

Filgrastim-sndz

Given SC

DRUG

Fludarabine

Given IV

DRUG

Melphalan

Given IV

DRUG

Mycophenolate Mofetil

Given IV or PO

BIOLOGICAL

Rituximab

Given IV

DRUG

Tacrolimus

Given IV

RADIATION

Total-Body Irradiation

Undergo total body irradiation

PROCEDURE

Umbilical Cord Blood Transplantation

Undergo cord blood transplant

Trial Locations (1)

77030

M D Anderson Cancer Center, Houston

All Listed Sponsors

collaborator

National Cancer Institute (NCI)

NIH

lead

M.D. Anderson Cancer Center

OTHER