Multiple Ascending Dose Study of MK-5160 in Participants With Type 1 and Type 2 Diabetes Mellitus (MK-5160-002)

PHASE1CompletedINTERVENTIONAL
Enrollment

33

Participants

Timeline

Start Date

April 12, 2017

Primary Completion Date

January 30, 2018

Study Completion Date

January 30, 2018

Conditions
Type 1 Diabetes MellitusType 2 Diabetes Mellitus
Interventions
BIOLOGICAL

MK-5160 16 nmol/kg

MK-5160 16 nmol/kg, subcutaneous injection administered daily for 12 days

BIOLOGICAL

MK-5160 32 nmol/kg

MK-5160 32 nmol/kg, subcutaneous injection administered daily for 12 days

BIOLOGICAL

MK-5160 64 nmol/kg

MK-5160 64 nmol/kg, subcutaneous injection administered daily for 12 days

BIOLOGICAL

Glargine 0.4 U/kg

Glargine 0.4 U/kg, subcutaneous injection administered daily for 12 days

BIOLOGICAL

Placebo to Glargine

Placebo to glargine, subcutaneous injection administered daily for 12 days

BIOLOGICAL

Placebo to MK-5160

Placebo to MK-5160, subcutaneous injection administered daily for 12 days

DRUG

Dextrose

20% solution of dextrose; adjusted to maintain the various glycemic levels at 100 mg/dL given as a continuous intravenous infusion for 6-30 hours.

BIOLOGICAL

Glargine 0.6 U/kg

Glargine 0.6 U/kg, subcutaneous injection administered daily for 12 days

Trial Locations (1)

91911

ProSciento Inc. ( Site 0001), Chula Vista

All Listed Sponsors
lead

Merck Sharp & Dohme LLC

INDUSTRY

NCT03095651 - Multiple Ascending Dose Study of MK-5160 in Participants With Type 1 and Type 2 Diabetes Mellitus (MK-5160-002) | Biotech Hunter | Biotech Hunter