PREemptive Pharmacogenomic Testing for Preventing Adverse Drug REactions

NACompletedINTERVENTIONAL
Enrollment

6,950

Participants

Timeline

Start Date

March 20, 2017

Primary Completion Date

September 30, 2020

Study Completion Date

May 1, 2021

Conditions
Adverse Drug Reaction
Interventions
OTHER

Pharmacogenomic testing

"The pharmacogenomic panel to be used incorporates 48 genetic variants for the following 13 pharamacogenes: CYP2B6 (cytochrome P450), CYP2C19, CYP2C9, CYP2D6,CYP3A4, DPYD (dihydropyrimidine dehydrogenase), FVL (factor five Leiden), HLA-B (human leukocyte antigen), NUDT15 (Nudix hydrolase), SLCO1B1 (solute carrier organic anion transporter), TPMT (thiopurine methyltransferase), UGT1A1 (UDP-glucuronosyltransferase), and VKORC1 (vitamin K epoxide reductase complex)."

Trial Locations (7)

Unknown

Medical University of Vienna, Vienna

University of Patras, Pátrai

Centro di Riferimento Oncologico, Aviano

Leiden University Medical Center, Leiden

University of Ljubljana, Ljubljana

Servicio Andaluz de Salud, Granada

University of Liverpool, Liverpool

All Listed Sponsors
collaborator

University of Liverpool

OTHER

collaborator

Medical University of Vienna

OTHER

collaborator

Centro di Riferimento Oncologico - Aviano

OTHER

collaborator

Andaluz Health Service

OTHER_GOV

collaborator

University of Patras

OTHER

collaborator

University of Ljubljana

OTHER

collaborator

Karolinska Institutet

OTHER

collaborator

The Golden Helix Foundation

UNKNOWN

collaborator

Royal Dutch Pharmacists Association (KNMP)

UNKNOWN

collaborator

Bio.Logis Genetic Information Management

UNKNOWN

collaborator

University Paul Sabatier of Toulouse

OTHER

collaborator

Uppsala University

OTHER

collaborator

Robert Bosch Gesellschaft für Medizinische Forschung mbH (RBMF)

OTHER

collaborator

Federal Institute for Drugs and Medical Devices

UNKNOWN

collaborator

St. Antonius Hospital

OTHER

lead

J.J.Swen

OTHER

NCT03093818 - PREemptive Pharmacogenomic Testing for Preventing Adverse Drug REactions | Biotech Hunter | Biotech Hunter