A Study of Repotrectinib (TPX-0005) in Patients With Advanced Solid Tumors Harboring ALK, ROS1, or NTRK1-3 Rearrangements

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

500

Participants

Timeline

Start Date

March 7, 2017

Primary Completion Date

February 29, 2028

Study Completion Date

February 29, 2028

Conditions
Locally Advanced Solid TumorsMetastatic Solid Tumors
Interventions
DRUG

Oral repotrectinib (TPX-0005)

Oral repotrectinib (TPX-0005) capsules.

Trial Locations (165)

0

ACTIVE_NOT_RECRUITING

Local Institution - 6502, Hong Kong

100

ACTIVE_NOT_RECRUITING

Local Institution - 6201, Taiepi

144

COMPLETED

Local Institution - 4308, Roma

704

ACTIVE_NOT_RECRUITING

Local Institution - 6203, Tainan City

1083

COMPLETED

Local Institution - 5101, Budapest

1121

COMPLETED

Local Institution - 5103, Budapest

2050

COMPLETED

Local Institution - 6102, Camperdown

2100

COMPLETED

Local Institution - 4901, Copenhagen

2650

COMPLETED

Local Institution - 4802, Antwerp

3000

COMPLETED

Local Institution - 6101, Melbourne

COMPLETED

Local Institution - 4801, Leuven

3002

COMPLETED

Local Institution - 3301, East Melbourne

5042

COMPLETED

Local Institution - 6103, Adelaide

8035

COMPLETED

Local Institution - 4101, Barcelona

10016

COMPLETED

Local Institution - 2117, New York

10065

COMPLETED

Local Institution - 2102, New York

RECRUITING

Memorial Sloan Kettering Cancer Center, New York

10449

COMPLETED

Local Institution - 6202, Taipei

13005

COMPLETED

Local Institution - 4201, Marseille

13125

COMPLETED

Local Institution - 4704, Berlin

20007

COMPLETED

Local Institution - 2106, Washington D.C.

20016

COMPLETED

Local Institution - 2110, Washington D.C.

20122

COMPLETED

Local Institution - 4306, Milan

20133

COMPLETED

Local Institution - 4301, Milan

21079

COMPLETED

Local Institution - 4204, Dijon

21210

COMPLETED

Local Institution - 2133, Baltimore

22031

COMPLETED

Local Institution - 2137, Fairfax

27534

COMPLETED

Local Institution - 2144, Goldsboro

28033

COMPLETED

Local Institution - 4106, Madrid

28040

COMPLETED

Local Institution - 4104, Madrid

28041

COMPLETED

Local Institution - 4103, Madrid

28050

COMPLETED

Local Institution - 4105, Madrid

28644

COMPLETED

Local Institution - 6306, Cheongju-si

29200

COMPLETED

Local Institution - 4207, Brest

30607

COMPLETED

Local Institution - 2139, Athens

31008

RECRUITING

Clinica Universidad de Navarra, Pamplona

31904

COMPLETED

Local Institution - 2134, Columbus

33021

COMPLETED

Local Institution - 2128, Hollywood

33081

COMPLETED

Local Institution - 4303, Pordenone

33612

COMPLETED

Local Institution - 2113, Tampa

38043

COMPLETED

Local Institution - 4206, Grenoble

38120

COMPLETED

Local Institution - 2148, Memphis

42123

COMPLETED

Local Institution - 4305, Reggio Emilia

43210

COMPLETED

Local Institution - 2123, Columbus

43614

COMPLETED

Local Institution - 2119, Toledo

44195

COMPLETED

Local Institution - 2109, Cleveland

44718

COMPLETED

Local Institution - 2112, Canton

45220

COMPLETED

Local Institution - 2143, Cincinnati

46009

RECRUITING

Instituto Valenciano de Oncología (IVO) - Unidad de Investigación Clínica FINCIVO, Valencia

48109

COMPLETED

Local Institution - 2105, Ann Arbor

48121

NOT_YET_RECRUITING

Local Institution - 4304, Ravenna

48201

COMPLETED

Local Institution - 2111, Detroit

50937

COMPLETED

Local Institution - 4701, Cologne

54911

COMPLETED

Local Institution - 2145, Appleton

55101

COMPLETED

Local Institution - 2132, Saint Paul

60637

COMPLETED

Local Institution - 2125, Chicago

61615

COMPLETED

Local Institution - 2142, Peoria

63110

COMPLETED

Local Institution - 2115, St Louis

65613

COMPLETED

Local Institution - 2147, Bolivar

69120

COMPLETED

Local Institution - 4702, Heidelberg

70121

NOT_YET_RECRUITING

Local Institution - 2116, New Orleans

75390

COMPLETED

Local Institution - 2130, Dallas

77030

COMPLETED

Local Institution - 2127, Houston

COMPLETED

Local Institution - 2138, Houston

77339

COMPLETED

Local Institution - 2146, Kingwood

80045

NOT_YET_RECRUITING

Local Institution - 1003, Aurora

COMPLETED

Local Institution - 2103, Aurora

86000

RECRUITING

Chu Poitiers, Poitiers

90146

WITHDRAWN

Local Institution - 4307, Palermo

90813

COMPLETED

Local Institution - 2121, Long Beach

91010

COMPLETED

Local Institution - 2129, Duarte

91206

COMPLETED

Local Institution - 2120, Glendale

92037

WITHDRAWN

Local Institution - 2136, La Jolla

92093

COMPLETED

Local Institution - 2114, La Jolla

92868

COMPLETED

Local Institution - 2101, Orange

RECRUITING

University of California Irvine Medical Center, Orange

94163

COMPLETED

Local Institution - 4203, Saint-Mandé

95403

COMPLETED

Local Institution - 2126, Santa Rosa

98109

COMPLETED

Local Institution - 2107, Seattle

98405

WITHDRAWN

Local Institution - 2141, Tacoma

RECRUITING

Institute Gustave Roussy, Villejuif

100021

COMPLETED

Local Institution - 6702, Beijing

100142

RECRUITING

Beijing Cancer hospital, Beijing

110801

RECRUITING

Liaoning Cancer Hospital, Shenyang

119074

COMPLETED

Local Institution - 6401, Singapore

130012

RECRUITING

Jilin Cancer Hospital/Medical Oncology Department, Changchun

RECRUITING

Jilin Cancer Hospital/Medical Oncology Department, Changchun

130021

RECRUITING

The first hospital of Jilin university-Oncology Department, Changchun

150081

RECRUITING

The Affiliated Tumor Hospital of Harbin Medical University, Harbin

169610

COMPLETED

Local Institution - 6402, Singapore

200030

RECRUITING

Shanghai Chest Hospital, Shanghai

RECRUITING

Shanghai Chest Hospital, Shanghai

210008

COMPLETED

Local Institution - 6748, Nanjing

230001

RECRUITING

Anhui Provincial Hospital, Hefei

310003

RECRUITING

The First Affiliated Hospital - Zhejiang University School of Medicine, Hangzhou

310016

COMPLETED

Local Institution - 6725, Hangzhou

310022

RECRUITING

Zhejiang Cancer Hospital-Oncology, Hangzhou

361003

RECRUITING

The First Affiliated hospital of Xiamen University-oncology, Xiamen

400030

RECRUITING

The First Hospital Affiliated To AMU - Southwest Hospital, Chongqing

410011

COMPLETED

Local Institution - 6705, Changsha

410013

RECRUITING

Hunan Cancer Hospital-thoracic oncology II, Changsha

430022

RECRUITING

Union Hospital Affiliated with Tongji Medical College of Huazhong University of Science and Technology/Cancer Center Department, Wuhan

510120

RECRUITING

Guangdong Provincial People'S Hospital, Guangzhou

COMPLETED

Local Institution - 6733, Guangzhou

518053

ACTIVE_NOT_RECRUITING

Local Institution - 6505, Shenzhen

710038

RECRUITING

Tangdu Hospital, Xi'an

999077

ACTIVE_NOT_RECRUITING

Local Institution - 6504, Shatin

1040045

RECRUITING

National Cancer Center Hospital., Chuo-ku

2418515

RECRUITING

Kanagawa cancer center, Yokohama

5340021

RECRUITING

Osaka City General Hospital, Osaka

5418567

RECRUITING

Osaka International Cancer institute, Osaka

02114

COMPLETED

Local Institution - 2104, Boston

02214

NOT_YET_RECRUITING

Local Institution - 1004, Boston

02215

COMPLETED

Local Institution - 2131, Boston

48202-2608

COMPLETED

Local Institution - 2140, Detroit

08901

COMPLETED

Local Institution - 2122, New Brunswick

19111-2497

COMPLETED

Local Institution - 2108, Philadelphia

T6G 1Z2

COMPLETED

Local Institution - 2202, Edmonton

V5Z 4E7

WITHDRAWN

Local Institution - 2205, Vancouver

M5G 2M9

COMPLETED

Local Institution - 2201, Toronto

ACTIVE_NOT_RECRUITING

Local Institution - 6503, Toronto

L6R 37R

COMPLETED

Local Institution - 2203, Ontario

K1H 8L6

COMPLETED

Local Institution - 2204, Ottawa

00000

RECRUITING

Daping Hospital, the Third Affiliated Hospital of Third Military Medical University /Cancer Center, Daping

RECRUITING

XuZhou Central Hospital/Oncology Department, Xuzhou

RECRUITING

Sichuan Cancer Hospital/Medical Oncology Department, Chengdu

RECRUITING

The Third Xiangya Hospital of Central South University/Department of Respiratory and Critical Care Medicine, Changsha

RECRUITING

West China Hospital Sichuan University/Lung cancer center, Chengdu

RECRUITING

Weifang People's Hospital/Medical Oncology Department, Weifang

RECRUITING

Henan Cancer Hospital/The 1st pneumology department, Zhengzhou

000000

COMPLETED

Local Institution - 6719, Fuzhou

030032

RECRUITING

Shanxi Bethune Hospital, Taiyuan

06189

RECRUITING

Centre Antoine-Lacassagne, Nice

01307

COMPLETED

Local Institution - 4703, Dresden

Unknown

ACTIVE_NOT_RECRUITING

Local Institution - 6501, Hong Kong

05100

COMPLETED

Local Institution - 4302, Terni

791-0295

RECRUITING

Ehime University Hospital, Tōon

0608648

RECRUITING

Hokkaido University Hospital, Sapporo

683-8504

RECRUITING

Tottori University Hospital, Yonago

277-8577

RECRUITING

National Cancer Center Hospital East, Kashiwa

466-8560

RECRUITING

Nagoya University Hospital, Nagoya

1066 CX

COMPLETED

Local Institution - 4502, Amsterdam

9713 GZ

COMPLETED

Local Institution - 4501, Groningen

80-214

RECRUITING

Ośrodek Badań Klinicznych Wczesnych Faz, Uniwersyteckie Centrum Kliniczne, Gdansk

20-609

COMPLETED

Local Institution - 4604, Lublin

60-693

COMPLETED

Local Institution - 4605, Poznan

70-784

COMPLETED

Local Institution - 4603, Szczecin

02-781

COMPLETED

Local Institution - 4602, Warsaw

06351

COMPLETED

Local Institution - 3003, Seoul

COMPLETED

Local Institution - 6303, Seoul

519-763

COMPLETED

Local Institution - 6308, Hwasun-eup, Hwasun-gun

03722

RECRUITING

Yonsei University Health System, Seoul

COMPLETED

Local Institution - 6302, Seoul

03080

WITHDRAWN

Local Institution - 3002, Seoul

COMPLETED

Local Institution - 6301, Seoul

RECRUITING

Seoul National University Hospital, Seoul

05030

COMPLETED

Local Institution - 6307, Seoul

05505

COMPLETED

Local Institution - 6305, Seoul

06591

COMPLETED

Local Institution - 6304, Seoul

08028

COMPLETED

Local Institution - 4102, Barcelona

SW3 6JJ

COMPLETED

Local Institution - 4401, London

W12 OHS

COMPLETED

Local Institution - 4402, London

W1G 6AD

COMPLETED

Local Institution - 4404, London

M20 4BX

COMPLETED

Local Institution - 4403, Manchester

SM2 5PT

COMPLETED

Local Institution - 4405, Sutton

All Listed Sponsors
collaborator

Zai Lab (Shanghai) Co., Ltd.

INDUSTRY

lead

Turning Point Therapeutics, Inc.

INDUSTRY