Adjunctive Corticosteroids for Tuberculous Meningitis in HIV-infected Adults (The ACT HIV Trial)

PHASE3CompletedINTERVENTIONAL
Enrollment

520

Participants

Timeline

Start Date

May 25, 2017

Primary Completion Date

April 30, 2022

Study Completion Date

April 26, 2023

Conditions
TuberculosisTuberculous MeningitisDrug-Induced Liver InjuryHIVIRIS
Interventions
DRUG

Dexamethasone

Active treatment with dexamethasone from randomisation (IV followed by oral according to disease severity at the start of treatment): dexamethasone for intravenous injection and dexamethasone for oral ingestion

OTHER

Placebo

"Treatment with matched placebo:~Standard saline for intravenous injection and placebo oral tablets containing cellulose"

Trial Locations (6)

Unknown

Cipto Mangunkusumo Hospital, Jakarta

Eijkman-Oxford Clinical Research Unit, Jakarta

RSUP Persahabatan Hospital, Jakarta

Hospital for Tropical Diseases, Ho Chi Minh City

Oxford University Clinical Research Unit, Ho Chi Minh City

Pham Ngoc Thach Hospital, Ho Chi Minh City

All Listed Sponsors
collaborator

Pham Ngoc Thach Hospital, Ho Chi Minh City, Vietnam

OTHER

collaborator

Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam

OTHER

collaborator

Dr Cipto Mangunkusumo General Hospital

OTHER

collaborator

RSUP Persahabatan Hospital, Jakarta, Indonesia

UNKNOWN

collaborator

Oxford University Clinical Research Unit Indonesia

OTHER

lead

Oxford University Clinical Research Unit, Vietnam

OTHER

NCT03092817 - Adjunctive Corticosteroids for Tuberculous Meningitis in HIV-infected Adults (The ACT HIV Trial) | Biotech Hunter | Biotech Hunter