27
Participants
Start Date
June 5, 2017
Primary Completion Date
April 5, 2024
Study Completion Date
July 24, 2024
Surgery
Heated Intraperitoneal Chemotherapy (HIPEC) with gastrectomy using cisplatin, mitomycin C and sodium thiosulfate
Cisplatin
Cisplatin (90 mg/m\^2) will be administered via circuit to the peritoneal cavity
Mitomycin C
Mitomycin C 10 mg/m\^2 will be administered via circuit to the peritoneal cavity
Sodium Thiosulfate
Sodium thiosulfate will be administered by continuous intravenous infusion starting immediately prior to the chemotherapy perfusion and continuing for a total of 12 hours.
Tumor Biopsy
At screening, baseline (if not done at screening) and operation (as clinically indicated).
CT C/A/P
At screening, baseline (if not done at screening), post op care, post-discharge visits/follow-up, semi-annual follow-up and annual follow-up.
PET-CT
At screening, baseline (if not done at screening), post op care, post-discharge visits/follow-up, semi-annual follow-up and annual follow-up.
MRI
If computed tomography (CT) contraindicated.
EKG
At screening and baseline (if not done at screening).
National Institutes of Health Clinical Center, Bethesda
National Cancer Institute (NCI)
NIH